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The map label for this gene is pepB [H]

Identifier: 123966726

GI number: 123966726

Start: 1327295

End: 1328782

Strand: Direct

Name: pepB [H]

Synonym: P9515_14931

Alternate gene names: 123966726

Gene position: 1327295-1328782 (Clockwise)

Preceding gene: 123966725

Following gene: 123966734

Centisome position: 77.88

GC content: 33.6

Gene sequence:

>1488_bases
ATGCAATTTTCAAATTTCCAACAAGATCTTAATACTTGGCAAGGTTCTATTTTAATATTTGGAATTGTTGAAGAGGATCT
TAAGAGCCAATTAGAAAAAATTTCTTGCATTATTGATTCAAAGTTGTTATTGGAAAAAATTAATCAAAAAAAATTCATAG
GAGAAAAGGGAAAGATCTTAAACTTCGATTTTTTTGATCAAAAATTACAATCTCTGAAGATTATTGGTCTTGGTAAAGGA
AAAAATATAAATATTAATGATATAAAAAATTTATTAGCAGACGTCATAAGAAAAAACGATGATAAAGATGAAAAAGTTAG
TATCATGTTTCCTTGGAATTTAATAAATTCTCCAGAAGAAATTAGATCTTTGGGAGAATCAGCAAGATTATCAGCCTATA
AAGATAATCGATTTAATAGCAAAAAGGATGATAAAAAAGTTCTAAAGGAAATTGAATTTTTGAATTTAAATAAATTTGAA
AATATAAACTTCAATGAGACAGAATATATTTGTGAAGGTGTTGAGCTTGCAAGGAGGCTGGTGGCTGCCCCCCCAAATAG
TCTTACTCCACTAGAAATGTCTAGACAAGCATCAATAATAGCTAAAGAACATGGTTTAGAAATTAAAATCCTCGATAGAA
AAGAATGTGAAGATTTAGGAATGGGTGCATATTTAGCAGTAGCTAAAGGTTCTGATTTAGAACCTAAATTTATTCACTTA
ACTTTAAAGTCAAAAAGTCCCATAAAAGAAAAGATTGCATTAGTGGGAAAAGGTTTAACCTTTGACTCAGGAGGATACAA
CCTAAAAGTTGGAGCTTCTCAAATTGAAATGATGAAATATGATATGGGTGGTAGCGCGTCGGTTTTAGGAGCCGCCAAAG
CACTCGGGGCTATAAAGCCAGACGGATTAGAAATACATTTCATTGTGGCAGCTTGCGAGAATATGATCAATGGATCCGCT
GTTCATCCAGGGGACGTAATAAAAGCTTCAAATGGCAAGACAATTGAGATTAACAATACTGATGCTGAGGGTAGGCTTAC
ATTGGCCGATGCATTAACCTATGCCTCAAATTTAAAACCTGATTCAATAATTGATCTTGCTACTTTGACTGGAGCTATTG
TTGTCGCATTAGGAAATGATGTAGCTGGTTTTTGGACCAACAACCATTTGATGGCAGAGGACTTAAAAATAGCATCATCC
CAAGCTGGAGAAGCATTGTGGCAAATGCCTTTACAAAAATCTTATAAGGATGGTCTTAAGTCTCATATTGCCGACATGAA
AAATACTGGGCCAAGGGCAGGCGGATCAATAACTGCTGCATTATTTCTAGAAGAATTTTTTGATAACAAAATAAAATGGG
CTCACATAGACATAGCTGGAACTTGTTGGACTGACAAAAGTAAAGGAATTAACCCCTTAGGAGCTACAGGATTCGGAGTT
AAAACTTTAGTCCAATGGATTAAAAATAAACGTCAAGATAATAAATAA

Upstream 100 bases:

>100_bases
AACTAATATATCTATGGATGCCGCCATTTAATAAGGAAACTAGAGATAGGTGGTCAACAACTTTTACAAACAACTAAAAA
TTAATTAAATCTTTTTAAAA

Downstream 100 bases:

>100_bases
TTATTCTTGAGACCAAGCATTCATTGATCTAGCATTGTCTTTCCATATTTTATCTAATTTCTGATCTCTGCCACAAGAGA
ATCTATAGAACTTATATTTT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MQFSNFQQDLNTWQGSILIFGIVEEDLKSQLEKISCIIDSKLLLEKINQKKFIGEKGKILNFDFFDQKLQSLKIIGLGKG
KNININDIKNLLADVIRKNDDKDEKVSIMFPWNLINSPEEIRSLGESARLSAYKDNRFNSKKDDKKVLKEIEFLNLNKFE
NINFNETEYICEGVELARRLVAAPPNSLTPLEMSRQASIIAKEHGLEIKILDRKECEDLGMGAYLAVAKGSDLEPKFIHL
TLKSKSPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSASVLGAAKALGAIKPDGLEIHFIVAACENMINGSA
VHPGDVIKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWTNNHLMAEDLKIASS
QAGEALWQMPLQKSYKDGLKSHIADMKNTGPRAGGSITAALFLEEFFDNKIKWAHIDIAGTCWTDKSKGINPLGATGFGV
KTLVQWIKNKRQDNK

Sequences:

>Translated_495_residues
MQFSNFQQDLNTWQGSILIFGIVEEDLKSQLEKISCIIDSKLLLEKINQKKFIGEKGKILNFDFFDQKLQSLKIIGLGKG
KNININDIKNLLADVIRKNDDKDEKVSIMFPWNLINSPEEIRSLGESARLSAYKDNRFNSKKDDKKVLKEIEFLNLNKFE
NINFNETEYICEGVELARRLVAAPPNSLTPLEMSRQASIIAKEHGLEIKILDRKECEDLGMGAYLAVAKGSDLEPKFIHL
TLKSKSPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSASVLGAAKALGAIKPDGLEIHFIVAACENMINGSA
VHPGDVIKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWTNNHLMAEDLKIASS
QAGEALWQMPLQKSYKDGLKSHIADMKNTGPRAGGSITAALFLEEFFDNKIKWAHIDIAGTCWTDKSKGINPLGATGFGV
KTLVQWIKNKRQDNK
>Mature_495_residues
MQFSNFQQDLNTWQGSILIFGIVEEDLKSQLEKISCIIDSKLLLEKINQKKFIGEKGKILNFDFFDQKLQSLKIIGLGKG
KNININDIKNLLADVIRKNDDKDEKVSIMFPWNLINSPEEIRSLGESARLSAYKDNRFNSKKDDKKVLKEIEFLNLNKFE
NINFNETEYICEGVELARRLVAAPPNSLTPLEMSRQASIIAKEHGLEIKILDRKECEDLGMGAYLAVAKGSDLEPKFIHL
TLKSKSPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSASVLGAAKALGAIKPDGLEIHFIVAACENMINGSA
VHPGDVIKASNGKTIEINNTDAEGRLTLADALTYASNLKPDSIIDLATLTGAIVVALGNDVAGFWTNNHLMAEDLKIASS
QAGEALWQMPLQKSYKDGLKSHIADMKNTGPRAGGSITAALFLEEFFDNKIKWAHIDIAGTCWTDKSKGINPLGATGFGV
KTLVQWIKNKRQDNK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=332, Percent_Identity=41.2650602409639, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI47155554, Length=397, Percent_Identity=31.7380352644836, Blast_Score=142, Evalue=1e-33,
Organism=Escherichia coli, GI1790710, Length=512, Percent_Identity=33.59375, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=36.4485981308411, Blast_Score=175, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=333, Percent_Identity=34.8348348348348, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17565172, Length=265, Percent_Identity=30.188679245283, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24661038, Length=316, Percent_Identity=33.2278481012658, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=33.0188679245283, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24662227, Length=458, Percent_Identity=27.0742358078603, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI161077148, Length=461, Percent_Identity=28.4164859002169, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20130057, Length=461, Percent_Identity=28.4164859002169, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20129969, Length=461, Percent_Identity=26.2472885032538, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21355645, Length=454, Percent_Identity=26.8722466960352, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24662223, Length=454, Percent_Identity=26.8722466960352, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI20129963, Length=460, Percent_Identity=28.0434782608696, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19922386, Length=455, Percent_Identity=26.1538461538462, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21357381, Length=355, Percent_Identity=32.3943661971831, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221379063, Length=355, Percent_Identity=32.3943661971831, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI221379062, Length=355, Percent_Identity=32.3943661971831, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646701, Length=357, Percent_Identity=26.0504201680672, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646703, Length=357, Percent_Identity=26.0504201680672, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358201, Length=357, Percent_Identity=26.0504201680672, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54506; Mature: 54506

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFSNFQQDLNTWQGSILIFGIVEEDLKSQLEKISCIIDSKLLLEKINQKKFIGEKGKIL
CCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
NFDFFDQKLQSLKIIGLGKGKNININDIKNLLADVIRKNDDKDEKVSIMFPWNLINSPEE
ECHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHCCCHHH
IRSLGESARLSAYKDNRFNSKKDDKKVLKEIEFLNLNKFENINFNETEYICEGVELARRL
HHHCCCHHHCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
VAAPPNSLTPLEMSRQASIIAKEHGLEIKILDRKECEDLGMGAYLAVAKGSDLEPKFIHL
HCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEEECCCCCCCEEEEE
TLKSKSPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSASVLGAAKALGAIKP
EECCCCCHHHHHHHHCCCCEECCCCCEEEECHHHEEEEEECCCCCHHHHHHHHHHCCCCC
DGLEIHFIVAACENMINGSAVHPGDVIKASNGKTIEINNTDAEGRLTLADALTYASNLKP
CCEEEEEHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHHCCCC
DSIIDLATLTGAIVVALGNDVAGFWTNNHLMAEDLKIASSQAGEALWQMPLQKSYKDGLK
CHHHHHHHHHCEEEEEECCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDNKIKWAHIDIAGTCWTDKSKGINPLGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNKRQDNK
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MQFSNFQQDLNTWQGSILIFGIVEEDLKSQLEKISCIIDSKLLLEKINQKKFIGEKGKIL
CCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
NFDFFDQKLQSLKIIGLGKGKNININDIKNLLADVIRKNDDKDEKVSIMFPWNLINSPEE
ECHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHCCCHHH
IRSLGESARLSAYKDNRFNSKKDDKKVLKEIEFLNLNKFENINFNETEYICEGVELARRL
HHHCCCHHHCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
VAAPPNSLTPLEMSRQASIIAKEHGLEIKILDRKECEDLGMGAYLAVAKGSDLEPKFIHL
HCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEEECCCCCCCEEEEE
TLKSKSPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSASVLGAAKALGAIKP
EECCCCCHHHHHHHHCCCCEECCCCCEEEECHHHEEEEEECCCCCHHHHHHHHHHCCCCC
DGLEIHFIVAACENMINGSAVHPGDVIKASNGKTIEINNTDAEGRLTLADALTYASNLKP
CCEEEEEHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEHHHHHHHHHCCCC
DSIIDLATLTGAIVVALGNDVAGFWTNNHLMAEDLKIASSQAGEALWQMPLQKSYKDGLK
CHHHHHHHHHCEEEEEECCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHIADMKNTGPRAGGSITAALFLEEFFDNKIKWAHIDIAGTCWTDKSKGINPLGATGFGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCH
KTLVQWIKNKRQDNK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]