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The map label for this gene is melB [C]

Identifier: 123966717

GI number: 123966717

Start: 1320039

End: 1321388

Strand: Direct

Name: melB [C]

Synonym: P9515_14841

Alternate gene names: 123966717

Gene position: 1320039-1321388 (Clockwise)

Preceding gene: 123966716

Following gene: 123966718

Centisome position: 77.46

GC content: 33.26

Gene sequence:

>1350_bases
ATGCTCTCTTATGGACTTGGAGATGCTGGTACAGGCTTAGCAGCCACACAATTTGGATTCTTTCTCTTTAGGTTCTTTAT
TTGTTCGGCAGGTTTACCAGTTTTAATTGCGGGTTCATTATTAATGTTGATAAAGATATGGGATGCGATAAATGATCCAT
TAATTGGATGGTTAAGTGATAGGACAAAATCTAAATGGGGACCAAGAATACCTTGGATGCTTGTTGCAGCTTTACCTCTT
GGGCTTTCTTTAGCGGCAATATGGTGGATACCTGCAGGTTCTGTCATAAACAAAACACTTTATTATACTTTAATTTCAAT
AATCGTAATGACTGCTTATACAAGCATCAATCTTCCTTTCGCCGCTTTATCTACTGAAATTTCAGAAAAAACTTCAATCA
GAACTAGATTAAATGCCGCGAGATTTACTGGATCAATAATAGCTGGTTTAACTGGATTAATAATAGCTGGAGTGGTTTTA
AATTCAAAAGGATTGGCTAATAACGAATATTTCTTAATGGGTAAAATCAGTGGGTTTATAGCGGTAACAACAACCTTAAT
ATCTTGTTGGGGATTAGCTCCATATGCCAAAAAAGCTAGGAAACCATCTGGGAAGGTCGAACCAATTAAACTCCAATTTA
AAAGAATATTTAATAATAAAAAATTTCTCAAAGTGATTTCTTTATATATTTTACTTTGGTGCGCCTTACAGTTAATGCAA
ACAGTTGCCTTAATTTATGTAGAAGATGTACTGAATGTGCCTTCAGAAATTGCTAACTGGGTTCCAATACCCTTCCAAAT
AAGTGCATTATTAGGATTACAAATATGGGCAAGAGTTTCAAATAAATTAAACAGAATTTCAGCTTTTAACTATGGGGCAA
TTATTTGGATAGTTTCATGTACAGCAGCATTATTTTTACCTTCTTTATCCAAAGTTTCATCTTTGGGAGATGGTGTATTT
CTAAATACTAATAACTTTATTCTATTTATAGTTTTAATTATCATTATTTGTCTAATTGGTATAGGTGCTTCAACTGCTTA
CCTAATTCCATGGTCACTTCTTCCTGATGCGATAGATGAAGATCCAGAAAAACCAGCAGGACTATATACCGCTTGGATGG
TTCTTATTCAGAAAATTGGTATTGGTCTAAGTGTTCAAATACTAGGCTTATTACTATACATATCTGGTTATCAATCATGC
ATTGTCGACAATTCCAGTTTTAATATTATTGAACAATCATCTTTAGCTCAATTAACCATAAGATTATGCATTGGTTTTAT
ACCTTCTTTATTAGTAATTACTGGAGTACTTATAATGCGAAAATGGGATCAAAAATTATTGCCCAACTAA

Upstream 100 bases:

>100_bases
TAGAATTACATTTGCAATAATACATTATCAAACAATCAACAAACAAAAAAGATTGGAAAATTCACACTCAAAAAATATAA
CAGGATCAAGAACAAGATTA

Downstream 100 bases:

>100_bases
TATAAATATATGTATTATCCAAAATTTTTTAAAAGACTTGTAAACAGCCTCATAATTGGAGGGCAAGCAATTAATTATAT
TTTCAAAGGGAAAATTTCCA

Product: GPH family sugar transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLSYGLGDAGTGLAATQFGFFLFRFFICSAGLPVLIAGSLLMLIKIWDAINDPLIGWLSDRTKSKWGPRIPWMLVAALPL
GLSLAAIWWIPAGSVINKTLYYTLISIIVMTAYTSINLPFAALSTEISEKTSIRTRLNAARFTGSIIAGLTGLIIAGVVL
NSKGLANNEYFLMGKISGFIAVTTTLISCWGLAPYAKKARKPSGKVEPIKLQFKRIFNNKKFLKVISLYILLWCALQLMQ
TVALIYVEDVLNVPSEIANWVPIPFQISALLGLQIWARVSNKLNRISAFNYGAIIWIVSCTAALFLPSLSKVSSLGDGVF
LNTNNFILFIVLIIIICLIGIGASTAYLIPWSLLPDAIDEDPEKPAGLYTAWMVLIQKIGIGLSVQILGLLLYISGYQSC
IVDNSSFNIIEQSSLAQLTIRLCIGFIPSLLVITGVLIMRKWDQKLLPN

Sequences:

>Translated_449_residues
MLSYGLGDAGTGLAATQFGFFLFRFFICSAGLPVLIAGSLLMLIKIWDAINDPLIGWLSDRTKSKWGPRIPWMLVAALPL
GLSLAAIWWIPAGSVINKTLYYTLISIIVMTAYTSINLPFAALSTEISEKTSIRTRLNAARFTGSIIAGLTGLIIAGVVL
NSKGLANNEYFLMGKISGFIAVTTTLISCWGLAPYAKKARKPSGKVEPIKLQFKRIFNNKKFLKVISLYILLWCALQLMQ
TVALIYVEDVLNVPSEIANWVPIPFQISALLGLQIWARVSNKLNRISAFNYGAIIWIVSCTAALFLPSLSKVSSLGDGVF
LNTNNFILFIVLIIIICLIGIGASTAYLIPWSLLPDAIDEDPEKPAGLYTAWMVLIQKIGIGLSVQILGLLLYISGYQSC
IVDNSSFNIIEQSSLAQLTIRLCIGFIPSLLVITGVLIMRKWDQKLLPN
>Mature_449_residues
MLSYGLGDAGTGLAATQFGFFLFRFFICSAGLPVLIAGSLLMLIKIWDAINDPLIGWLSDRTKSKWGPRIPWMLVAALPL
GLSLAAIWWIPAGSVINKTLYYTLISIIVMTAYTSINLPFAALSTEISEKTSIRTRLNAARFTGSIIAGLTGLIIAGVVL
NSKGLANNEYFLMGKISGFIAVTTTLISCWGLAPYAKKARKPSGKVEPIKLQFKRIFNNKKFLKVISLYILLWCALQLMQ
TVALIYVEDVLNVPSEIANWVPIPFQISALLGLQIWARVSNKLNRISAFNYGAIIWIVSCTAALFLPSLSKVSSLGDGVF
LNTNNFILFIVLIIIICLIGIGASTAYLIPWSLLPDAIDEDPEKPAGLYTAWMVLIQKIGIGLSVQILGLLLYISGYQSC
IVDNSSFNIIEQSSLAQLTIRLCIGFIPSLLVITGVLIMRKWDQKLLPN

Specific function: Unknown

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Homo sapiens, GI42713696, Length=438, Percent_Identity=23.7442922374429, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI211063479, Length=451, Percent_Identity=23.2815964523282, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI122937339, Length=466, Percent_Identity=21.0300429184549, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786466, Length=450, Percent_Identity=24.2222222222222, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082306, Length=402, Percent_Identity=20.8955223880597, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790561, Length=461, Percent_Identity=22.7765726681128, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994989, Length=462, Percent_Identity=23.1601731601732, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787902, Length=157, Percent_Identity=28.6624203821656, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 49160; Mature: 49160

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYGLGDAGTGLAATQFGFFLFRFFICSAGLPVLIAGSLLMLIKIWDAINDPLIGWLSD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHH
RTKSKWGPRIPWMLVAALPLGLSLAAIWWIPAGSVINKTLYYTLISIIVMTAYTSINLPF
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
AALSTEISEKTSIRTRLNAARFTGSIIAGLTGLIIAGVVLNSKGLANNEYFLMGKISGFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHH
AVTTTLISCWGLAPYAKKARKPSGKVEPIKLQFKRIFNNKKFLKVISLYILLWCALQLMQ
HHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TVALIYVEDVLNVPSEIANWVPIPFQISALLGLQIWARVSNKLNRISAFNYGAIIWIVSC
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TAALFLPSLSKVSSLGDGVFLNTNNFILFIVLIIIICLIGIGASTAYLIPWSLLPDAIDE
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCHHHCC
DPEKPAGLYTAWMVLIQKIGIGLSVQILGLLLYISGYQSCIVDNSSFNIIEQSSLAQLTI
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHEEECCCCCEEEHHHHHHHHH
RLCIGFIPSLLVITGVLIMRKWDQKLLPN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSYGLGDAGTGLAATQFGFFLFRFFICSAGLPVLIAGSLLMLIKIWDAINDPLIGWLSD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHH
RTKSKWGPRIPWMLVAALPLGLSLAAIWWIPAGSVINKTLYYTLISIIVMTAYTSINLPF
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
AALSTEISEKTSIRTRLNAARFTGSIIAGLTGLIIAGVVLNSKGLANNEYFLMGKISGFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHH
AVTTTLISCWGLAPYAKKARKPSGKVEPIKLQFKRIFNNKKFLKVISLYILLWCALQLMQ
HHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TVALIYVEDVLNVPSEIANWVPIPFQISALLGLQIWARVSNKLNRISAFNYGAIIWIVSC
HHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TAALFLPSLSKVSSLGDGVFLNTNNFILFIVLIIIICLIGIGASTAYLIPWSLLPDAIDE
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCHHHCC
DPEKPAGLYTAWMVLIQKIGIGLSVQILGLLLYISGYQSCIVDNSSFNIIEQSSLAQLTI
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHEEECCCCCEEEHHHHHHHHH
RLCIGFIPSLLVITGVLIMRKWDQKLLPN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]