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The map label for this gene is clpP [H]

Identifier: 123966708

GI number: 123966708

Start: 1312603

End: 1313208

Strand: Direct

Name: clpP [H]

Synonym: P9515_14751

Alternate gene names: 123966708

Gene position: 1312603-1313208 (Clockwise)

Preceding gene: 123966707

Following gene: 123966709

Centisome position: 77.02

GC content: 37.95

Gene sequence:

>606_bases
ATGCCAATAGGAACTCCAAGCGTGCCTTATAGACTTCCAGGAAGTCAATATGAAAGATGGGTAGACATTTATACAAGATT
AGGTGTAGAAAGAATTTTATTTCTCGGACAAGAAGTCAATGATGGCATTGCTAATAGCCTTGTTGCTCAAATGCTTTACC
TCGATTCTGATGATAATACAAAACCTATTTATCTTTATATAAATAGTCCGGGGGGATCCGTTACTGCTGGATTAGCGATA
TATGACACTATCAAATACGTAAAAAGTGACGTAGTTACTATATGTGTTGGGCTAGCAGCCTCTATGGGAGCATTTTTATT
AGGAGCTGGGACTAAGGGTAAAAGAGTTGCTCTTCCTCACAGTAGAATCATGATTCATCAACCATTAGGGGGCACCTCAC
AACGTCAGGCGAGTGATATTGAGATAGAAGCTCGAGAAATACTTAGAATCAAAGATATGTTGAACAAATCCATGGCAGAT
ATGACTGGTCAATCTTTCGAAAAAATAGAGAAAGATACAGACAGAGATTATTTTCTTAGTGCTGAAGAAGCTAAAAACTA
TGGACTTATCGATAGAGTAATTTCACACCCAAGTGAGGCAAATTAG

Upstream 100 bases:

>100_bases
AGCTTTAGATTACGGAGTAATCGATAGAATACTTACAAGTCAAAAAGATTTGCCAAATAAAATTTAACTCTTACTTTTAA
TTAACTATTTTTCTAAAATT

Downstream 100 bases:

>100_bases
ATCAAATATACGAAAATAATATTTAAATATTAATTTTTAAATGAGCAATTATATGGTTTATTTACACATTTAATGTCTAA
AATAATAACTATCAAAAGTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MPIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNTKPIYLYINSPGGSVTAGLAI
YDTIKYVKSDVVTICVGLAASMGAFLLGAGTKGKRVALPHSRIMIHQPLGGTSQRQASDIEIEAREILRIKDMLNKSMAD
MTGQSFEKIEKDTDRDYFLSAEEAKNYGLIDRVISHPSEAN

Sequences:

>Translated_201_residues
MPIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNTKPIYLYINSPGGSVTAGLAI
YDTIKYVKSDVVTICVGLAASMGAFLLGAGTKGKRVALPHSRIMIHQPLGGTSQRQASDIEIEAREILRIKDMLNKSMAD
MTGQSFEKIEKDTDRDYFLSAEEAKNYGLIDRVISHPSEAN
>Mature_200_residues
PIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNTKPIYLYINSPGGSVTAGLAIY
DTIKYVKSDVVTICVGLAASMGAFLLGAGTKGKRVALPHSRIMIHQPLGGTSQRQASDIEIEAREILRIKDMLNKSMADM
TGQSFEKIEKDTDRDYFLSAEEAKNYGLIDRVISHPSEAN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=182, Percent_Identity=51.0989010989011, Blast_Score=193, Evalue=7e-50,
Organism=Escherichia coli, GI1786641, Length=182, Percent_Identity=61.5384615384615, Blast_Score=232, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17538017, Length=179, Percent_Identity=54.7486033519553, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129427, Length=182, Percent_Identity=51.6483516483517, Blast_Score=191, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22163; Mature: 22031

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
KPIYLYINSPGGSVTAGLAIYDTIKYVKSDVVTICVGLAASMGAFLLGAGTKGKRVALPH
CEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCC
SRIMIHQPLGGTSQRQASDIEIEAREILRIKDMLNKSMADMTGQSFEKIEKDTDRDYFLS
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEE
AEEAKNYGLIDRVISHPSEAN
HHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
PIGTPSVPYRLPGSQYERWVDIYTRLGVERILFLGQEVNDGIANSLVAQMLYLDSDDNT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
KPIYLYINSPGGSVTAGLAIYDTIKYVKSDVVTICVGLAASMGAFLLGAGTKGKRVALPH
CEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCC
SRIMIHQPLGGTSQRQASDIEIEAREILRIKDMLNKSMADMTGQSFEKIEKDTDRDYFLS
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEE
AEEAKNYGLIDRVISHPSEAN
HHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA