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The map label for this gene is lpd [H]

Identifier: 123966692

GI number: 123966692

Start: 1293810

End: 1295249

Strand: Reverse

Name: lpd [H]

Synonym: P9515_14591

Alternate gene names: 123966692

Gene position: 1295249-1293810 (Counterclockwise)

Preceding gene: 123966693

Following gene: 123966691

Centisome position: 76.0

GC content: 36.32

Gene sequence:

>1440_bases
GTGACTGATTTAAATTTTGACTTTGATTTAATAGTAATTGGCGCAGGGTATGGAGGGTTTGATGCAGCCAAACATGCTGC
AGGCAAAGGTCTTAAAGTTGCTATCGTTGAGTCTGGAGATATGGGAGGCACTTGTGTAAATAAAGGGTGCGTGCCTTCGA
AAGCTCTTTTGGCAGCAAGTGGAAAAGTTAGAGAAATAGCCAATTATGAACATTTATCAAGGTTCGGTATTCATGCTTCA
CCTGTCAGATTCGAAAGATCAAAGATTGCTGATCATGCTAATAACTTAGTCTCAAATGTAAGAGAAAATTTAACAAAAAC
TCTAAAAAGAAGTGGAGTTGAAATTATCTTAGGATTTGGAAGACTTGAGGGTAATCAAAAAGTAGGAGTAAGAGATAAGA
ATGGAATTGATAAGATCTTTACATGTAAAAATACAGTTATTGCTTCAGGTTCTTCTCCTTTTGTACCTCCCGGAATAAAT
TTAGATAATAGAACAGTTTTCACAAGTGATGAAGCAGTTAAACTTGAATGGCTCCCAAGATGGATAGCTATTATTGGAAG
TGGATATATAGGTTTAGAATTCGCCGATGTATATACTGCTCTAGGTTGTGAAGTGACCATGATCGAGGCTTTAGAAAATA
TAATGCCCACCTTTGACCCTGATATTACAAAAATAGCTAAGAAAAATCTAATTCAATCAAGAGATATTGACACTAAGTCT
AATGTATTTGCGACTAAGATCACACCCGGATGCCCCGTAAAGATAGAACTTACGGATGCAAAATCAAAGGAAATTGTTGA
GAACTTAGAAGTTGATGCCGTTCTTGTGGCTACTGGCAGGAGTCCTAATAGTAAGAATCTAAATCTTGATTCAGTTGGTA
TCGAAACTGTTAAAGGTTATATTCCTATTGATGATCAAATGAGAGTGATAAATGGTAAAAAAATAATTCCTAATGTTTGG
GCCGTTGGTGATGTTACTGGTAAACTTATGCTCGCCCATACAGCAGCAGCTCAAGGAACAATAGCTGTTGATAATATATG
TGGAAAAAATATTGAGATTAATTATGGAAGTATTCCAGCTGCAACATTTACTCACCCTGAGATAAGTTCAGTAGGCCTAT
CTGAAACTGATGCTAAAGAAAAAGCAATTAAAGAAGATTTTACTTTAGGGGTTGTGAAAAGCTATTTTAAAGCTAATTCC
AAGGCACTAGCAGAATTAGAAAGCGATGGAATTCTTAAGTTACTTTTCAATAAAGATAGTGGAAAAGTATTAGGCGCGCA
CATCTTTGGAATGCATGCAGCTGATTTGATTCAAGAAATTGCAAATGCGATCTCTAGAAATCAAGATGTAATTCAGCTAG
CTTCTGAAGTACATACTCACCCTACTCTTAGTGAAGTCGTTGAGGTCGCCTATAAACAGGCAGCTTCTCAAGTAAAGTAA

Upstream 100 bases:

>100_bases
ATAGTGAGCTTGTAGAATCATTGAATGTGGCTTGTGTTGCAGTTCCGTTATTACTTGAACGAAAAAGAGTCGCATATATT
TCTAATTCAAGAATACAAAA

Downstream 100 bases:

>100_bases
TTGATTTTTTATGGAAATAAGACGTAGGCCACCAAATCCAACAGTTAGGGTAGAAAATTTAGAGTATGCCGTTCCTCATA
GAGAGGCAAAAGCAAAAAAT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; LPD; E3 component of pyruvate complex [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTDLNFDFDLIVIGAGYGGFDAAKHAAGKGLKVAIVESGDMGGTCVNKGCVPSKALLAASGKVREIANYEHLSRFGIHAS
PVRFERSKIADHANNLVSNVRENLTKTLKRSGVEIILGFGRLEGNQKVGVRDKNGIDKIFTCKNTVIASGSSPFVPPGIN
LDNRTVFTSDEAVKLEWLPRWIAIIGSGYIGLEFADVYTALGCEVTMIEALENIMPTFDPDITKIAKKNLIQSRDIDTKS
NVFATKITPGCPVKIELTDAKSKEIVENLEVDAVLVATGRSPNSKNLNLDSVGIETVKGYIPIDDQMRVINGKKIIPNVW
AVGDVTGKLMLAHTAAAQGTIAVDNICGKNIEINYGSIPAATFTHPEISSVGLSETDAKEKAIKEDFTLGVVKSYFKANS
KALAELESDGILKLLFNKDSGKVLGAHIFGMHAADLIQEIANAISRNQDVIQLASEVHTHPTLSEVVEVAYKQAASQVK

Sequences:

>Translated_479_residues
MTDLNFDFDLIVIGAGYGGFDAAKHAAGKGLKVAIVESGDMGGTCVNKGCVPSKALLAASGKVREIANYEHLSRFGIHAS
PVRFERSKIADHANNLVSNVRENLTKTLKRSGVEIILGFGRLEGNQKVGVRDKNGIDKIFTCKNTVIASGSSPFVPPGIN
LDNRTVFTSDEAVKLEWLPRWIAIIGSGYIGLEFADVYTALGCEVTMIEALENIMPTFDPDITKIAKKNLIQSRDIDTKS
NVFATKITPGCPVKIELTDAKSKEIVENLEVDAVLVATGRSPNSKNLNLDSVGIETVKGYIPIDDQMRVINGKKIIPNVW
AVGDVTGKLMLAHTAAAQGTIAVDNICGKNIEINYGSIPAATFTHPEISSVGLSETDAKEKAIKEDFTLGVVKSYFKANS
KALAELESDGILKLLFNKDSGKVLGAHIFGMHAADLIQEIANAISRNQDVIQLASEVHTHPTLSEVVEVAYKQAASQVK
>Mature_478_residues
TDLNFDFDLIVIGAGYGGFDAAKHAAGKGLKVAIVESGDMGGTCVNKGCVPSKALLAASGKVREIANYEHLSRFGIHASP
VRFERSKIADHANNLVSNVRENLTKTLKRSGVEIILGFGRLEGNQKVGVRDKNGIDKIFTCKNTVIASGSSPFVPPGINL
DNRTVFTSDEAVKLEWLPRWIAIIGSGYIGLEFADVYTALGCEVTMIEALENIMPTFDPDITKIAKKNLIQSRDIDTKSN
VFATKITPGCPVKIELTDAKSKEIVENLEVDAVLVATGRSPNSKNLNLDSVGIETVKGYIPIDDQMRVINGKKIIPNVWA
VGDVTGKLMLAHTAAAQGTIAVDNICGKNIEINYGSIPAATFTHPEISSVGLSETDAKEKAIKEDFTLGVVKSYFKANSK
ALAELESDGILKLLFNKDSGKVLGAHIFGMHAADLIQEIANAISRNQDVIQLASEVHTHPTLSEVVEVAYKQAASQVK

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=478, Percent_Identity=34.9372384937238, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI50301238, Length=483, Percent_Identity=30.4347826086957, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI291045266, Length=485, Percent_Identity=28.4536082474227, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33519430, Length=485, Percent_Identity=26.1855670103093, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI33519428, Length=485, Percent_Identity=26.1855670103093, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI33519426, Length=485, Percent_Identity=26.1855670103093, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI148277065, Length=485, Percent_Identity=26.1855670103093, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI148277071, Length=485, Percent_Identity=26.1855670103093, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=25.8947368421053, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI291045268, Length=482, Percent_Identity=25.9336099585062, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=33.0453563714903, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082354, Length=475, Percent_Identity=28.8421052631579, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1789915, Length=452, Percent_Identity=28.5398230088496, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI87081717, Length=468, Percent_Identity=26.9230769230769, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32565766, Length=485, Percent_Identity=31.9587628865979, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=29.4605809128631, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=473, Percent_Identity=30.4439746300211, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=473, Percent_Identity=30.4439746300211, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982272, Length=498, Percent_Identity=25.7028112449799, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321091, Length=484, Percent_Identity=34.0909090909091, Blast_Score=216, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6325166, Length=479, Percent_Identity=27.7661795407098, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=483, Percent_Identity=27.3291925465839, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21358499, Length=476, Percent_Identity=34.8739495798319, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24640549, Length=499, Percent_Identity=28.8577154308617, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24640553, Length=499, Percent_Identity=28.8577154308617, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640551, Length=499, Percent_Identity=28.8577154308617, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737741, Length=503, Percent_Identity=26.2425447316103, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 51446; Mature: 51314

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLNFDFDLIVIGAGYGGFDAAKHAAGKGLKVAIVESGDMGGTCVNKGCVPSKALLAAS
CCCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHCC
GKVREIANYEHLSRFGIHASPVRFERSKIADHANNLVSNVRENLTKTLKRSGVEIILGFG
CCHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
RLEGNQKVGVRDKNGIDKIFTCKNTVIASGSSPFVPPGINLDNRTVFTSDEAVKLEWLPR
EECCCCEECCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCEEEECCCEEEEEHHHH
WIAIIGSGYIGLEFADVYTALGCEVTMIEALENIMPTFDPDITKIAKKNLIQSRDIDTKS
HHHHHCCCCCEEEHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
NVFATKITPGCPVKIELTDAKSKEIVENLEVDAVLVATGRSPNSKNLNLDSVGIETVKGY
CEEEEECCCCCCEEEEECCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHEECE
IPIDDQMRVINGKKIIPNVWAVGDVTGKLMLAHTAAAQGTIAVDNICGKNIEINYGSIPA
ECCCCCEEEECCCEECCCEEEECCCCCEEEEEEECCCCCCEEECCCCCCEEEEECCCCCC
ATFTHPEISSVGLSETDAKEKAIKEDFTLGVVKSYFKANSKALAELESDGILKLLFNKDS
CEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEECCC
GKVLGAHIFGMHAADLIQEIANAISRNQDVIQLASEVHTHPTLSEVVEVAYKQAASQVK
CCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDLNFDFDLIVIGAGYGGFDAAKHAAGKGLKVAIVESGDMGGTCVNKGCVPSKALLAAS
CCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHCC
GKVREIANYEHLSRFGIHASPVRFERSKIADHANNLVSNVRENLTKTLKRSGVEIILGFG
CCHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
RLEGNQKVGVRDKNGIDKIFTCKNTVIASGSSPFVPPGINLDNRTVFTSDEAVKLEWLPR
EECCCCEECCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCEEEECCCEEEEEHHHH
WIAIIGSGYIGLEFADVYTALGCEVTMIEALENIMPTFDPDITKIAKKNLIQSRDIDTKS
HHHHHCCCCCEEEHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
NVFATKITPGCPVKIELTDAKSKEIVENLEVDAVLVATGRSPNSKNLNLDSVGIETVKGY
CEEEEECCCCCCEEEEECCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHEECE
IPIDDQMRVINGKKIIPNVWAVGDVTGKLMLAHTAAAQGTIAVDNICGKNIEINYGSIPA
ECCCCCEEEECCCEECCCEEEECCCCCEEEEEEECCCCCCEEECCCCCCEEEEECCCCCC
ATFTHPEISSVGLSETDAKEKAIKEDFTLGVVKSYFKANSKALAELESDGILKLLFNKDS
CEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEECCC
GKVLGAHIFGMHAADLIQEIANAISRNQDVIQLASEVHTHPTLSEVVEVAYKQAASQVK
CCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231; 9387233 [H]