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The map label for this gene is fbp [H]

Identifier: 123966687

GI number: 123966687

Start: 1290719

End: 1291291

Strand: Direct

Name: fbp [H]

Synonym: P9515_14541

Alternate gene names: 123966687

Gene position: 1290719-1291291 (Clockwise)

Preceding gene: 123966685

Following gene: 123966688

Centisome position: 75.74

GC content: 34.21

Gene sequence:

>573_bases
GTGAAAGAAGTTTTAATTAGTTTTACGATTTTTGTATTTTGCATTTCATTAACTCTTTTTAGTCAATTTAATTCTCCTCA
AGTTGTTAATGCATCTGAATCAAAAACTGAAATCGTAAATAAAATACCTACTACAAAATCATCTAATGTTTCGAATACCA
ACATATTCGAACTAGACCCATCTGACCCAAACCCAATACTTTTTGCCATGGTTGAAGAAACACAAGAAGACAGCAACTCT
AGAACTACAGAAAGTGGATTGATTATTTTAGATATGGTTAAAGGAGAGGGAGATGAAGCTAACTCAGGACAAACAGTTAC
TGTTAATTATACTGGAATTCTAGAGGATGGAACCCAATTTGATACCAGTATTGGTAGGGCGCCATTCAGTTTCCCATTAG
GTGCTGGAAGAGTAATTAAGGGTTGGGATGAAGGAGTAGCTGGAATGAAAGTAGGAGGGAAAAGAAAATTAACAATACCT
CCTGAATTAGGTTACGGAACAAGAGGAGCTGGAAATGTAATTCCTGCAAATGCAACTTTAATTTTTGAAGTTGAATTATT
AAAAGTCAATTAA

Upstream 100 bases:

>100_bases
GTGTTGTTTAACAATATAAAATTTCTAAATTAATTTTTTAAAAAACATAAATTATTGTACCTTTTTCTGTAGTATTAAAT
GTAGTAACTTTTTAAATTCA

Downstream 100 bases:

>100_bases
AGTAAGAAATAACATCCAAAACTTTTCAATTTAGTTAAACAACAAGTAAGATATATTCAGTTATACAAAAACGAATGTTA
ACTAAATTATTAAATTCTTT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKEVLISFTIFVFCISLTLFSQFNSPQVVNASESKTEIVNKIPTTKSSNVSNTNIFELDPSDPNPILFAMVEETQEDSNS
RTTESGLIILDMVKGEGDEANSGQTVTVNYTGILEDGTQFDTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIP
PELGYGTRGAGNVIPANATLIFEVELLKVN

Sequences:

>Translated_190_residues
MKEVLISFTIFVFCISLTLFSQFNSPQVVNASESKTEIVNKIPTTKSSNVSNTNIFELDPSDPNPILFAMVEETQEDSNS
RTTESGLIILDMVKGEGDEANSGQTVTVNYTGILEDGTQFDTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIP
PELGYGTRGAGNVIPANATLIFEVELLKVN
>Mature_190_residues
MKEVLISFTIFVFCISLTLFSQFNSPQVVNASESKTEIVNKIPTTKSSNVSNTNIFELDPSDPNPILFAMVEETQEDSNS
RTTESGLIILDMVKGEGDEANSGQTVTVNYTGILEDGTQFDTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIP
PELGYGTRGAGNVIPANATLIFEVELLKVN

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=58.0645161290323, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=58.0645161290323, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=58.0645161290323, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI17149836, Length=91, Percent_Identity=54.9450549450549, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4503725, Length=91, Percent_Identity=54.9450549450549, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4758380, Length=90, Percent_Identity=51.1111111111111, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4503729, Length=104, Percent_Identity=49.0384615384615, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI224809329, Length=121, Percent_Identity=47.1074380165289, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI224809327, Length=121, Percent_Identity=47.1074380165289, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI4758384, Length=121, Percent_Identity=47.1074380165289, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI224809331, Length=121, Percent_Identity=47.1074380165289, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4503727, Length=167, Percent_Identity=36.5269461077844, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=46.7391304347826, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI192448443, Length=92, Percent_Identity=44.5652173913043, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI33469985, Length=92, Percent_Identity=42.3913043478261, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI7706131, Length=91, Percent_Identity=40.6593406593407, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI206725547, Length=127, Percent_Identity=37.007874015748, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI31317231, Length=128, Percent_Identity=37.5, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI150010552, Length=117, Percent_Identity=35.042735042735, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI87082390, Length=120, Percent_Identity=47.5, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1789745, Length=120, Percent_Identity=45, Blast_Score=80, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=99, Percent_Identity=58.5858585858586, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=52.6881720430108, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17561782, Length=104, Percent_Identity=50, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17561778, Length=102, Percent_Identity=45.0980392156863, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17506169, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506167, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993555, Length=68, Percent_Identity=54.4117647058823, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17561780, Length=111, Percent_Identity=40.5405405405405, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=58.5106382978723, Blast_Score=105, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323482, Length=116, Percent_Identity=44.8275862068966, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323566, Length=119, Percent_Identity=42.0168067226891, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324194, Length=90, Percent_Identity=53.3333333333333, Blast_Score=98, Evalue=7e-22,
Organism=Drosophila melanogaster, GI281363946, Length=93, Percent_Identity=59.1397849462366, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17352457, Length=93, Percent_Identity=59.1397849462366, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24647110, Length=113, Percent_Identity=52.212389380531, Blast_Score=116, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=51.8867924528302, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356629, Length=94, Percent_Identity=58.5106382978723, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583150, Length=105, Percent_Identity=49.5238095238095, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20439; Mature: 20439

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVLISFTIFVFCISLTLFSQFNSPQVVNASESKTEIVNKIPTTKSSNVSNTNIFELDP
CCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCEEEEECC
SDPNPILFAMVEETQEDSNSRTTESGLIILDMVKGEGDEANSGQTVTVNYTGILEDGTQF
CCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCC
DTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIPPELGYGTRGAGNVIPANATL
CHHCCCCCCCCCCCCCCEEECCCCCCCCEEECCCEEEECCCCCCCCCCCCCCEEECCEEE
IFEVELLKVN
EEEEEEEEEC
>Mature Secondary Structure
MKEVLISFTIFVFCISLTLFSQFNSPQVVNASESKTEIVNKIPTTKSSNVSNTNIFELDP
CCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCEEEEECC
SDPNPILFAMVEETQEDSNSRTTESGLIILDMVKGEGDEANSGQTVTVNYTGILEDGTQF
CCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCC
DTSIGRAPFSFPLGAGRVIKGWDEGVAGMKVGGKRKLTIPPELGYGTRGAGNVIPANATL
CHHCCCCCCCCCCCCCCEEECCCCCCCCEEECCCEEEECCCCCCCCCCCCCCEEECCEEE
IFEVELLKVN
EEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]