The gene/protein map for NC_008817 is currently unavailable.
Definition Prochlorococcus marinus str. MIT 9515, complete genome.
Accession NC_008817
Length 1,704,176

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The map label for this gene is serS

Identifier: 123966593

GI number: 123966593

Start: 1192296

End: 1193573

Strand: Direct

Name: serS

Synonym: P9515_13601

Alternate gene names: 123966593

Gene position: 1192296-1193573 (Clockwise)

Preceding gene: 123966592

Following gene: 123966594

Centisome position: 69.96

GC content: 30.91

Gene sequence:

>1278_bases
GTGTTAGATCAAAAATTAATAAGAGAAAATCCAACATTTGTGGAAAATAATTTATCCTTAAGAGGTAAATTTTATGATAT
TCATTCCATACATAAGATTACTGTAGAAAGAAAGGAAATTGATATCAAAATATCAAGCCTACAATCAGAGAGTAAAAAAT
TAAGCAAAATAATTGGCCAAGAGATAAGAAATCCCAATAATGCTAATTCTCAAGAACTCAATAAATTAAAAGAACAAGGA
AATAAATACAGAATAAAAGTTTCAGAATTTGAAGAAAAAAAAAGAATACTAGATCAACAAATCCGAGATGAAATATTAAA
ACTACCTAATTTCCCAAGTAAAGATGCACCATTTGGAGAAAACGAAAGTAATAATATTCAAATAAAAGAATGGGGAGATC
CGCTAAAAAAAGATAATCTTAAAACTCATTGGGAAATAGGTGAAAATTTAAAGCTATTTGATTCCATAAAATCAACAAAA
ATTGCAAAAAGTCGTTTTATTACTCTTTCAGGCAATGGCGCAAGGCTGGAGAGAGCTTTAATTAATTTTATGCTAGATGT
TCATTCAAATAATGGTTATTTAGAGTTAATGCCTCCAGCGTTAGTTAATTCAGAAAGTCTTCAAGGATCAGGTCAACTAC
CTAAATTTTCAAATGAGAGTTTTAAGTGTGCTAATGATGACTTATGGCTCTCTCCAACAGCAGAAGTACCTCTGACTGCC
TTTCATAAAAATGAGATTATTGATCCAAAACTTTTGCCTTTAAAATACGTAGCTTATAGTCCTTGTTTTAGGAGAGAAGC
TGGTAGTTATGGAAGGGATACAAAAGGGTTAATAAGACTTCATCAATTTAATAAGGTTGAATTATATTGGTTTAGTGATC
CAAATAAATCTTTAGAGGCTCATAAAGAAATAACTGCGGACGCAGAGAGTATTTTAAAAAAACTAAATTTACCATACAGA
TTAGTAGATATTTGCACTGGAGATTTAGGTTTTTCTTCTAGCAGAACTTTTGATCTTGAGGTTTGGTTACCTAGCAATAA
ATGTTACAGAGAAATATCTAGTTGCAGTAATTGTCGAGACTTTCAGGCTCGTAGATCATCAATAAGAACAAAAATTGATA
AGAAAACTTCATATATCCACACTCTAAATGGAAGTGGTTTAGCTATAGGAAGAACAATGGCAGCAATTCTTGAGAATGGC
CAGAGACCTGATGGAAGTGTAAAAATTCCTGATGTTCTTGTTCCATACTTTGGATCATCTTTAATAAAAACTAACTAA

Upstream 100 bases:

>100_bases
CAAAGTTAGTAATCCCTTACTTAATTAATTTTTCAGCAAAAAGCTCTGATAATTATTTGAGATAAACTATCTTATTAAGA
AATAAAAGATTAAAAAAAGA

Downstream 100 bases:

>100_bases
AATATAATAATGAATGTTTTAACCTCAATAACAGTATTAGGATTTCTCATTTTTTTTCACGAAATGGGTCATTTTCTTGC
GGCAATATTCCAAGGGATAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDQKLIRENPTFVENNLSLRGKFYDIHSIHKITVERKEIDIKISSLQSESKKLSKIIGQEIRNPNNANSQELNKLKEQG
NKYRIKVSEFEEKKRILDQQIRDEILKLPNFPSKDAPFGENESNNIQIKEWGDPLKKDNLKTHWEIGENLKLFDSIKSTK
IAKSRFITLSGNGARLERALINFMLDVHSNNGYLELMPPALVNSESLQGSGQLPKFSNESFKCANDDLWLSPTAEVPLTA
FHKNEIIDPKLLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFSDPNKSLEAHKEITADAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSNKCYREISSCSNCRDFQARRSSIRTKIDKKTSYIHTLNGSGLAIGRTMAAILENG
QRPDGSVKIPDVLVPYFGSSLIKTN

Sequences:

>Translated_425_residues
MLDQKLIRENPTFVENNLSLRGKFYDIHSIHKITVERKEIDIKISSLQSESKKLSKIIGQEIRNPNNANSQELNKLKEQG
NKYRIKVSEFEEKKRILDQQIRDEILKLPNFPSKDAPFGENESNNIQIKEWGDPLKKDNLKTHWEIGENLKLFDSIKSTK
IAKSRFITLSGNGARLERALINFMLDVHSNNGYLELMPPALVNSESLQGSGQLPKFSNESFKCANDDLWLSPTAEVPLTA
FHKNEIIDPKLLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFSDPNKSLEAHKEITADAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSNKCYREISSCSNCRDFQARRSSIRTKIDKKTSYIHTLNGSGLAIGRTMAAILENG
QRPDGSVKIPDVLVPYFGSSLIKTN
>Mature_425_residues
MLDQKLIRENPTFVENNLSLRGKFYDIHSIHKITVERKEIDIKISSLQSESKKLSKIIGQEIRNPNNANSQELNKLKEQG
NKYRIKVSEFEEKKRILDQQIRDEILKLPNFPSKDAPFGENESNNIQIKEWGDPLKKDNLKTHWEIGENLKLFDSIKSTK
IAKSRFITLSGNGARLERALINFMLDVHSNNGYLELMPPALVNSESLQGSGQLPKFSNESFKCANDDLWLSPTAEVPLTA
FHKNEIIDPKLLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFSDPNKSLEAHKEITADAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSNKCYREISSCSNCRDFQARRSSIRTKIDKKTSYIHTLNGSGLAIGRTMAAILENG
QRPDGSVKIPDVLVPYFGSSLIKTN

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=308, Percent_Identity=36.3636363636364, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI8923421, Length=408, Percent_Identity=29.4117647058824, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI225579074, Length=411, Percent_Identity=29.4403892944039, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=43.6915887850467, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17539260, Length=328, Percent_Identity=34.1463414634146, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=319, Percent_Identity=30.4075235109718, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=396, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=387, Percent_Identity=32.5581395348837, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=30.6034482758621, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI17737985, Length=285, Percent_Identity=32.6315789473684, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PROM5 (A2BXQ6)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011674.1
- ProteinModelPortal:   A2BXQ6
- SMR:   A2BXQ6
- STRING:   A2BXQ6
- GeneID:   4718795
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_13601
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   PMAR167542:P9515ORF_1421-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48454; Mature: 48454

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLDQKLIRENPTFVENNLSLRGKFYDIHSIHKITVERKEIDIKISSLQSESKKLSKIIGQ
CCCHHHHHCCCCEEECCCEEEEEEEEECCEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHH
EIRNPNNANSQELNKLKEQGNKYRIKVSEFEEKKRILDQQIRDEILKLPNFPSKDAPFGE
HHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NESNNIQIKEWGDPLKKDNLKTHWEIGENLKLFDSIKSTKIAKSRFITLSGNGARLERAL
CCCCCEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHEEHEEEEEEECCCHHHHHHH
INFMLDVHSNNGYLELMPPALVNSESLQGSGQLPKFSNESFKCANDDLWLSPTAEVPLTA
HHHHHEEECCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCEEE
FHKNEIIDPKLLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFSDPNKSLEA
ECCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCHHHEEEEECCEEEEEEECCCCCCHHH
HKEITADAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSNKCYREISSCSNCRD
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHH
FQARRSSIRTKIDKKTSYIHTLNGSGLAIGRTMAAILENGQRPDGSVKIPDVLVPYFGSS
HHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHCCCC
LIKTN
CCCCC
>Mature Secondary Structure
MLDQKLIRENPTFVENNLSLRGKFYDIHSIHKITVERKEIDIKISSLQSESKKLSKIIGQ
CCCHHHHHCCCCEEECCCEEEEEEEEECCEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHH
EIRNPNNANSQELNKLKEQGNKYRIKVSEFEEKKRILDQQIRDEILKLPNFPSKDAPFGE
HHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NESNNIQIKEWGDPLKKDNLKTHWEIGENLKLFDSIKSTKIAKSRFITLSGNGARLERAL
CCCCCEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHEEHEEEEEEECCCHHHHHHH
INFMLDVHSNNGYLELMPPALVNSESLQGSGQLPKFSNESFKCANDDLWLSPTAEVPLTA
HHHHHEEECCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEECCCCEEECCCCCCCEEE
FHKNEIIDPKLLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFSDPNKSLEA
ECCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCHHHEEEEECCEEEEEEECCCCCCHHH
HKEITADAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSNKCYREISSCSNCRD
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHH
FQARRSSIRTKIDKKTSYIHTLNGSGLAIGRTMAAILENGQRPDGSVKIPDVLVPYFGSS
HHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHCCCC
LIKTN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA