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The map label for this gene is cobQ

Identifier: 123966560

GI number: 123966560

Start: 1165360

End: 1166892

Strand: Direct

Name: cobQ

Synonym: P9515_13271

Alternate gene names: 123966560

Gene position: 1165360-1166892 (Clockwise)

Preceding gene: 123966558

Following gene: 123966561

Centisome position: 68.38

GC content: 30.01

Gene sequence:

>1533_bases
ATGGAATTCACAGAAAACTATAATCCGAAAAATAAACCAATTATGGTTTTAGGAACTTCTAGTGGAGCTGGTAAATCATT
AACAGTCACTGCAATATGCAGGATATTGAAAAAACTTGGTGAAGAGCCAATACCTTTTAAAGGACAAAATATGAGTAACA
ATGCTTGGGTTGATTCTAATGGTGGAGAAATGGCATATTCACAAGCATTACAAGCATTTTCTTGCGGGATTAATCCTTCT
TCCGAAATGAATCCTATTTTATTAAAACCACAGGGTGATTCTACAAGTGAAGTCATTCATTTAGGAAAAAGTGTAGGGAT
TTCAACAGCAAAAGATTACTACAAAGATTGGTTTATGCCGGGATGGGAAGTTATTAAAAAAAGTATAAATATCATTTATG
AGAAAAACAAAAATTGCCGATTAATCATTGAGGGGGCCGGAAGTCCTGTAGAAATGAACTTAATTCATAGGGATCTAACT
AACTTAAGAGTTGCAAAGTATTTAGACGCGAGTTGTATTTTAGTAACGGATATTGAAAGAGGAGGCGTATTTGCACAAAT
AATAGGAACTCTTGAGTTAATGAAACCTGAAGAAAGAAAGCTCATAAAAGGGATATTAATAAATAGATTTAGAGGAGACC
TTTCTTTATTTAAAGAAGGTAAAAAATGGATAGAAGATAAAACTAAAATTCCTGTTTTAGGAATAATTCCTTGGTTAAAC
GATAAATTCCCTCCAGAAGATTCTTTAGATTTGTTAGAAAGAAAATCTTATTTGAGTAATCCTGAAATAAAAGTTGGGAT
TATAAAATTACCATCTATAAGTAATTTTTCAGATTTTGATCCATTAGAAAATGAAAATTCCATATTAATAGAATGGATCA
GTGAAGCCCAAAACTTGAATCAATTTGATTTTATTATTATTCCTGGAAGTAAACAGACTATAAAAGATCAACTATTTCTT
AATGAGTCTGGATTGTCAAAAGAGATTAAAAACTATTCACACAATAATGGCAATATTTTCGGAATTTGTGGAGGTCTACA
AATGTTGGGAACAGTTCTAGAAGACCCATTTTTTAAAGAAGGCTCAAATTTTAATTCAGATCAATCAATTAAGGGGATTG
GATTACTACCTTTAAAAACAACTTTTCTTAAACATAAAATAACAAGACAAATTCACTCTGAATCAATTTGGCCGAACTCA
ACAAAAATCATTGGATTTGAGATACATAATGGAATTACTAAATTAGATAGTAGTCATCTTGATACTTTAAAAACAAATCA
TATATTTAAAGATTTCGATCTTGGATGGTATAAAGAGAATAGAGAGGGAGGGACTATTGCGGGAACATACATTCATGGGA
TTTTTGAAAATGATGAATGGAGAGATCACTATATAAATTTAATTAGAAAGACTAAAAACAAACTGACATTAGACAAGAAA
TCAAGATCATATAAAATGAAACGAGAATCTATTATTAACAATTTAGCGAACGAATTTAATAATCATTTCAATATTTCATT
GCTATTAAATTGA

Upstream 100 bases:

>100_bases
TTCTAGATCGAGAAGCAGAGGCTAGAATTAACACAAATTTTTTATTAAATTATACTTTAAATTAAAGATTATTAAATTAA
TAATTTAATATCAATAACGA

Downstream 100 bases:

>100_bases
CAAACTCTAAAATTAAAATCACTTGGCCAAATAATATTGATACATATGCCTATGATGGAGACGATTGGTTTCTAATTGCT
GAAAAGGTAGGTTTGGAAAT

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MEFTENYNPKNKPIMVLGTSSGAGKSLTVTAICRILKKLGEEPIPFKGQNMSNNAWVDSNGGEMAYSQALQAFSCGINPS
SEMNPILLKPQGDSTSEVIHLGKSVGISTAKDYYKDWFMPGWEVIKKSINIIYEKNKNCRLIIEGAGSPVEMNLIHRDLT
NLRVAKYLDASCILVTDIERGGVFAQIIGTLELMKPEERKLIKGILINRFRGDLSLFKEGKKWIEDKTKIPVLGIIPWLN
DKFPPEDSLDLLERKSYLSNPEIKVGIIKLPSISNFSDFDPLENENSILIEWISEAQNLNQFDFIIIPGSKQTIKDQLFL
NESGLSKEIKNYSHNNGNIFGICGGLQMLGTVLEDPFFKEGSNFNSDQSIKGIGLLPLKTTFLKHKITRQIHSESIWPNS
TKIIGFEIHNGITKLDSSHLDTLKTNHIFKDFDLGWYKENREGGTIAGTYIHGIFENDEWRDHYINLIRKTKNKLTLDKK
SRSYKMKRESIINNLANEFNNHFNISLLLN

Sequences:

>Translated_510_residues
MEFTENYNPKNKPIMVLGTSSGAGKSLTVTAICRILKKLGEEPIPFKGQNMSNNAWVDSNGGEMAYSQALQAFSCGINPS
SEMNPILLKPQGDSTSEVIHLGKSVGISTAKDYYKDWFMPGWEVIKKSINIIYEKNKNCRLIIEGAGSPVEMNLIHRDLT
NLRVAKYLDASCILVTDIERGGVFAQIIGTLELMKPEERKLIKGILINRFRGDLSLFKEGKKWIEDKTKIPVLGIIPWLN
DKFPPEDSLDLLERKSYLSNPEIKVGIIKLPSISNFSDFDPLENENSILIEWISEAQNLNQFDFIIIPGSKQTIKDQLFL
NESGLSKEIKNYSHNNGNIFGICGGLQMLGTVLEDPFFKEGSNFNSDQSIKGIGLLPLKTTFLKHKITRQIHSESIWPNS
TKIIGFEIHNGITKLDSSHLDTLKTNHIFKDFDLGWYKENREGGTIAGTYIHGIFENDEWRDHYINLIRKTKNKLTLDKK
SRSYKMKRESIINNLANEFNNHFNISLLLN
>Mature_510_residues
MEFTENYNPKNKPIMVLGTSSGAGKSLTVTAICRILKKLGEEPIPFKGQNMSNNAWVDSNGGEMAYSQALQAFSCGINPS
SEMNPILLKPQGDSTSEVIHLGKSVGISTAKDYYKDWFMPGWEVIKKSINIIYEKNKNCRLIIEGAGSPVEMNLIHRDLT
NLRVAKYLDASCILVTDIERGGVFAQIIGTLELMKPEERKLIKGILINRFRGDLSLFKEGKKWIEDKTKIPVLGIIPWLN
DKFPPEDSLDLLERKSYLSNPEIKVGIIKLPSISNFSDFDPLENENSILIEWISEAQNLNQFDFIIIPGSKQTIKDQLFL
NESGLSKEIKNYSHNNGNIFGICGGLQMLGTVLEDPFFKEGSNFNSDQSIKGIGLLPLKTTFLKHKITRQIHSESIWPNS
TKIIGFEIHNGITKLDSSHLDTLKTNHIFKDFDLGWYKENREGGTIAGTYIHGIFENDEWRDHYINLIRKTKNKLTLDKK
SRSYKMKRESIINNLANEFNNHFNISLLLN

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_PROM5 (A2BXM3)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011641.1
- ProteinModelPortal:   A2BXM3
- STRING:   A2BXM3
- GeneID:   4718847
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_13271
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   ICLPRIS
- ProtClustDB:   PRK00784
- BioCyc:   PMAR167542:P9515ORF_1386-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 57764; Mature: 57764

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 343-343 ACT_SITE 452-452

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTENYNPKNKPIMVLGTSSGAGKSLTVTAICRILKKLGEEPIPFKGQNMSNNAWVDSN
CCCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
GGEMAYSQALQAFSCGINPSSEMNPILLKPQGDSTSEVIHLGKSVGISTAKDYYKDWFMP
CCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
GWEVIKKSINIIYEKNKNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLDASCILVTDIER
CHHHHHHHHHEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCC
GGVFAQIIGTLELMKPEERKLIKGILINRFRGDLSLFKEGKKWIEDKTKIPVLGIIPWLN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
DKFPPEDSLDLLERKSYLSNPEIKVGIIKLPSISNFSDFDPLENENSILIEWISEAQNLN
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEHHHHCCCC
QFDFIIIPGSKQTIKDQLFLNESGLSKEIKNYSHNNGNIFGICGGLQMLGTVLEDPFFKE
CEEEEEECCCCHHHHHHHEECCCCCHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCC
GSNFNSDQSIKGIGLLPLKTTFLKHKITRQIHSESIWPNSTKIIGFEIHNGITKLDSSHL
CCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHCCCHHH
DTLKTNHIFKDFDLGWYKENREGGTIAGTYIHGIFENDEWRDHYINLIRKTKNKLTLDKK
HHHHHCCEEECCCCCEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHEEECCC
SRSYKMKRESIINNLANEFNNHFNISLLLN
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MEFTENYNPKNKPIMVLGTSSGAGKSLTVTAICRILKKLGEEPIPFKGQNMSNNAWVDSN
CCCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
GGEMAYSQALQAFSCGINPSSEMNPILLKPQGDSTSEVIHLGKSVGISTAKDYYKDWFMP
CCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
GWEVIKKSINIIYEKNKNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLDASCILVTDIER
CHHHHHHHHHEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCC
GGVFAQIIGTLELMKPEERKLIKGILINRFRGDLSLFKEGKKWIEDKTKIPVLGIIPWLN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
DKFPPEDSLDLLERKSYLSNPEIKVGIIKLPSISNFSDFDPLENENSILIEWISEAQNLN
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEHHHHCCCC
QFDFIIIPGSKQTIKDQLFLNESGLSKEIKNYSHNNGNIFGICGGLQMLGTVLEDPFFKE
CEEEEEECCCCHHHHHHHEECCCCCHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCC
GSNFNSDQSIKGIGLLPLKTTFLKHKITRQIHSESIWPNSTKIIGFEIHNGITKLDSSHL
CCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHCCCHHH
DTLKTNHIFKDFDLGWYKENREGGTIAGTYIHGIFENDEWRDHYINLIRKTKNKLTLDKK
HHHHHCCEEECCCCCEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHEEECCC
SRSYKMKRESIINNLANEFNNHFNISLLLN
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA