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The map label for this gene is apt

Identifier: 123966448

GI number: 123966448

Start: 1071447

End: 1071962

Strand: Reverse

Name: apt

Synonym: P9515_12151

Alternate gene names: 123966448

Gene position: 1071962-1071447 (Counterclockwise)

Preceding gene: 123966450

Following gene: 123966446

Centisome position: 62.9

GC content: 31.2

Gene sequence:

>516_bases
ATGGAGAATAAGCTTATAGAGTTGATTGAAACATATAATGATTTTCCTAGAAAAGGAATTGAATTCAAAGATGTTTTAGG
AATTATTCAAGAACCAAAGATATTTAAAGAACTTATTTTAAAGATGTCATCTAGTCAAATCATTAGAAATGCTGAGGCAA
TAATTTCTATAGATGCTAGGGGTTTTATTTTTGGTTCTGCAATATCCCTGGAAGCCTCAAAACCAATGATCGTAGCAAGA
AAGCCTGGTAAGCTCCCAGGAGAACTTTCAAAAAAAAAATACAGTTTAGAATATGGTGAGAATTCACTTTCAATACAAAA
AAAATGCCTTCAGAAATATAACTCATATGCGATTGTTGATGATTTATTGGCTACTGGTGGAACGGTGAGTTGTGTTTCTA
AATTACTTGAGAGTAATGGTAAAGAAGTTTTAGGATTATTAGTTGTCGTTGAATTGATGAAGTTGAAAGGAAGATTTAAA
TTGAAGTTTCCTGTTGAATCATCGATAACTTTTTGA

Upstream 100 bases:

>100_bases
TTTCATCTACTTTTAAAAAGATTTAGTGTAAATAACTTAAACTAGTTAAAATTAAAATAAAATTAAATTTAATAGAACCT
ATTTAAATCGAAATTGAGAA

Downstream 100 bases:

>100_bases
AAATTGAATTTATTTTTTCACCATATGCTTTGAAAGCTATAGCAATTTCAAAATATAACTTTTCATAAATTTATGAATTA
TTGAGAATACCATGCCTAAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MENKLIELIETYNDFPRKGIEFKDVLGIIQEPKIFKELILKMSSSQIIRNAEAIISIDARGFIFGSAISLEASKPMIVAR
KPGKLPGELSKKKYSLEYGENSLSIQKKCLQKYNSYAIVDDLLATGGTVSCVSKLLESNGKEVLGLLVVVELMKLKGRFK
LKFPVESSITF

Sequences:

>Translated_171_residues
MENKLIELIETYNDFPRKGIEFKDVLGIIQEPKIFKELILKMSSSQIIRNAEAIISIDARGFIFGSAISLEASKPMIVAR
KPGKLPGELSKKKYSLEYGENSLSIQKKCLQKYNSYAIVDDLLATGGTVSCVSKLLESNGKEVLGLLVVVELMKLKGRFK
LKFPVESSITF
>Mature_171_residues
MENKLIELIETYNDFPRKGIEFKDVLGIIQEPKIFKELILKMSSSQIIRNAEAIISIDARGFIFGSAISLEASKPMIVAR
KPGKLPGELSKKKYSLEYGENSLSIQKKCLQKYNSYAIVDDLLATGGTVSCVSKLLESNGKEVLGLLVVVELMKLKGRFK
LKFPVESSITF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=39.5209580838323, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI71773201, Length=132, Percent_Identity=37.8787878787879, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=33.5443037974684, Blast_Score=100, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17509087, Length=160, Percent_Identity=33.75, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323619, Length=161, Percent_Identity=36.6459627329193, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320649, Length=160, Percent_Identity=30.625, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136334, Length=165, Percent_Identity=36.3636363636364, Blast_Score=102, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PROM5 (A2BXB1)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011529.1
- ProteinModelPortal:   A2BXB1
- SMR:   A2BXB1
- STRING:   A2BXB1
- GeneID:   4718906
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_12151
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   PMAR167542:P9515ORF_1268-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19050; Mature: 19050

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKLIELIETYNDFPRKGIEFKDVLGIIQEPKIFKELILKMSSSQIIRNAEAIISIDAR
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEEECCC
GFIFGSAISLEASKPMIVARKPGKLPGELSKKKYSLEYGENSLSIQKKCLQKYNSYAIVD
CEEEECEEEECCCCCEEEEECCCCCCCCHHHHEEEHHCCCCHHHHHHHHHHHHCCHHHHH
DLLATGGTVSCVSKLLESNGKEVLGLLVVVELMKLKGRFKLKFPVESSITF
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure
MENKLIELIETYNDFPRKGIEFKDVLGIIQEPKIFKELILKMSSSQIIRNAEAIISIDAR
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEEECCC
GFIFGSAISLEASKPMIVARKPGKLPGELSKKKYSLEYGENSLSIQKKCLQKYNSYAIVD
CEEEECEEEECCCCCEEEEECCCCCCCCHHHHEEEHHCCCCHHHHHHHHHHHHCCHHHHH
DLLATGGTVSCVSKLLESNGKEVLGLLVVVELMKLKGRFKLKFPVESSITF
HHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA