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The map label for this gene is thrA [H]

Identifier: 123966375

GI number: 123966375

Start: 994977

End: 996278

Strand: Reverse

Name: thrA [H]

Synonym: P9515_11421

Alternate gene names: 123966375

Gene position: 996278-994977 (Counterclockwise)

Preceding gene: 123966376

Following gene: 123966374

Centisome position: 58.46

GC content: 31.26

Gene sequence:

>1302_bases
ATGGGAAAATGTAAAATTGGTATTATAGGTTTTGGAACTGTAGGGACTGGTATTTATAGAATTTTGAAATCGAGAAATGA
TGTTCATCCTATTTTAAAAGATATAGAAATTGTTGGAATAGCTGTTAAAAATATTAATAAAAATAGAAATATTGAATTAG
AAAATAATCTATTAATAGATGATCCTAATAAATTAATTAACGACTCTAATATTGACGTAATTGTAGAAGTAATGGGAGGT
ACGGATATGGCCAAAGATATTATTTTAAAATCTCTAAAAGCTCGAAAATCTGTAGTTACAGCGAACAAAGCAGTCATCGC
AAGATATGGGAGTGAAATATATGCTACGGCTGCAAAGTATGGGGTTTATGTTTTAACAGAAGCAGCAGTTTGCGGAGGGA
TCCCAATAATTGAACCTTTAAAAAGATCTCTTAAAAGTAATCAAATAAATAAAATAGTTGGGATAATAAACGGCACAACA
AATTTTATTCTTTCAAAAATGACAAATGAAAAAGCTGATTATGAGGAAACATTAAAACTAGCTCAAAAACTAGGGTTTGC
AGAATTTGATCCAACTGCTGATGTTGAAGGTCATGATGCAGCTGATAAGATTTCAATTCTTTCTGAACTGGCATTTGGAG
GAAGAATTAATAGAGATTCAATTAGTACGGAAGGCATTAATCAAATAAATATTAAAGATATTGAATATGCAAATAAACTT
GGTTTTGAAATAAAACTCTTAGCCTTCTCAGAGAGAAATACTATCAATAACAAAAATTCTCTTTCCTTAAATATTTGGGT
AGGACCCTCTTTAATTCCTAAATATCATCCTTTAGCAAAGGTTGACGGTGTAAATAATGCCATTCTTATAGAGTCATATC
CACTTGGAGAAATAATGTTATACGGCCCAGGTGCGGGCAGTGGTCCAACGGCAGCTTCTGTAGTTTCTGATATATTAAAT
CTTCAGGCTTCATTATCAAAAAATTTACCTACAAAAGATCCATTATTATCTTTTAATTTTTGGAGAGACTGTCACATAAT
AGATTTCAATCAAATATCAAAAAAGAATTATCTCAGAATTATTTGTTTAGATTCTCCTGGTGTAATTGGTAAGATCGGAG
ATTTATTTGGGAAGAATGATGTCTCAATAGAATCAATAGTTCAACTAGATGCAAGTGAGAATAAAGCTGAAATAGTTGTT
ATCACTCATGAAGTGTCAAATGGTAACTTTGAAAAATCAAAGGAGGGGATAAGAGCCCTTCCTGAAGTTGAATTAATTGC
CAGCCAATTAAGTTGTATTTGA

Upstream 100 bases:

>100_bases
CAAATGGATTTTTAAATATACTTTTAAAAATGCAGTCTCAGGCAAATGATTTTTTGTCGGAATAATATTATAAAATTGAA
CCTATATTAAAATTTAAAAA

Downstream 100 bases:

>100_bases
AGAAAATATTTGCAAATCCCTCTTTAGCTTGTTAAACCGAAGTAAGTAAATTTACTTTAGTAATGTTTTATTCAAATTTA
ATAGATAGTAAAAGTAATAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MGKCKIGIIGFGTVGTGIYRILKSRNDVHPILKDIEIVGIAVKNINKNRNIELENNLLIDDPNKLINDSNIDVIVEVMGG
TDMAKDIILKSLKARKSVVTANKAVIARYGSEIYATAAKYGVYVLTEAAVCGGIPIIEPLKRSLKSNQINKIVGIINGTT
NFILSKMTNEKADYEETLKLAQKLGFAEFDPTADVEGHDAADKISILSELAFGGRINRDSISTEGINQINIKDIEYANKL
GFEIKLLAFSERNTINNKNSLSLNIWVGPSLIPKYHPLAKVDGVNNAILIESYPLGEIMLYGPGAGSGPTAASVVSDILN
LQASLSKNLPTKDPLLSFNFWRDCHIIDFNQISKKNYLRIICLDSPGVIGKIGDLFGKNDVSIESIVQLDASENKAEIVV
ITHEVSNGNFEKSKEGIRALPEVELIASQLSCI

Sequences:

>Translated_433_residues
MGKCKIGIIGFGTVGTGIYRILKSRNDVHPILKDIEIVGIAVKNINKNRNIELENNLLIDDPNKLINDSNIDVIVEVMGG
TDMAKDIILKSLKARKSVVTANKAVIARYGSEIYATAAKYGVYVLTEAAVCGGIPIIEPLKRSLKSNQINKIVGIINGTT
NFILSKMTNEKADYEETLKLAQKLGFAEFDPTADVEGHDAADKISILSELAFGGRINRDSISTEGINQINIKDIEYANKL
GFEIKLLAFSERNTINNKNSLSLNIWVGPSLIPKYHPLAKVDGVNNAILIESYPLGEIMLYGPGAGSGPTAASVVSDILN
LQASLSKNLPTKDPLLSFNFWRDCHIIDFNQISKKNYLRIICLDSPGVIGKIGDLFGKNDVSIESIVQLDASENKAEIVV
ITHEVSNGNFEKSKEGIRALPEVELIASQLSCI
>Mature_432_residues
GKCKIGIIGFGTVGTGIYRILKSRNDVHPILKDIEIVGIAVKNINKNRNIELENNLLIDDPNKLINDSNIDVIVEVMGGT
DMAKDIILKSLKARKSVVTANKAVIARYGSEIYATAAKYGVYVLTEAAVCGGIPIIEPLKRSLKSNQINKIVGIINGTTN
FILSKMTNEKADYEETLKLAQKLGFAEFDPTADVEGHDAADKISILSELAFGGRINRDSISTEGINQINIKDIEYANKLG
FEIKLLAFSERNTINNKNSLSLNIWVGPSLIPKYHPLAKVDGVNNAILIESYPLGEIMLYGPGAGSGPTAASVVSDILNL
QASLSKNLPTKDPLLSFNFWRDCHIIDFNQISKKNYLRIICLDSPGVIGKIGDLFGKNDVSIESIVQLDASENKAEIVVI
THEVSNGNFEKSKEGIRALPEVELIASQLSCI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=248, Percent_Identity=27.4193548387097, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47137; Mature: 47006

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKCKIGIIGFGTVGTGIYRILKSRNDVHPILKDIEIVGIAVKNINKNRNIELENNLLID
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHCCEEEEEEEECCCCCCCEEECCCEEEE
DPNKLINDSNIDVIVEVMGGTDMAKDIILKSLKARKSVVTANKAVIARYGSEIYATAAKY
CCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHEEHHHHC
GVYVLTEAAVCGGIPIIEPLKRSLKSNQINKIVGIINGTTNFILSKMTNEKADYEETLKL
CEEEEEEHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHH
AQKLGFAEFDPTADVEGHDAADKISILSELAFGGRINRDSISTEGINQINIKDIEYANKL
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECEEHHHHHHHC
GFEIKLLAFSERNTINNKNSLSLNIWVGPSLIPKYHPLAKVDGVNNAILIESYPLGEIML
CCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCEEEEECCCCCEEEE
YGPGAGSGPTAASVVSDILNLQASLSKNLPTKDPLLSFNFWRDCHIIDFNQISKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEHHHCCCCCCEEE
ICLDSPGVIGKIGDLFGKNDVSIESIVQLDASENKAEIVVITHEVSNGNFEKSKEGIRAL
EEECCCCCEEHHHHHCCCCCCCHHHHEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHCC
PEVELIASQLSCI
CHHHHHHHHHHCC
>Mature Secondary Structure 
GKCKIGIIGFGTVGTGIYRILKSRNDVHPILKDIEIVGIAVKNINKNRNIELENNLLID
CCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHCCEEEEEEEECCCCCCCEEECCCEEEE
DPNKLINDSNIDVIVEVMGGTDMAKDIILKSLKARKSVVTANKAVIARYGSEIYATAAKY
CCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHEECCCCHHEEHHHHC
GVYVLTEAAVCGGIPIIEPLKRSLKSNQINKIVGIINGTTNFILSKMTNEKADYEETLKL
CEEEEEEHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHH
AQKLGFAEFDPTADVEGHDAADKISILSELAFGGRINRDSISTEGINQINIKDIEYANKL
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECEEHHHHHHHC
GFEIKLLAFSERNTINNKNSLSLNIWVGPSLIPKYHPLAKVDGVNNAILIESYPLGEIML
CCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCEEEEECCCCCEEEE
YGPGAGSGPTAASVVSDILNLQASLSKNLPTKDPLLSFNFWRDCHIIDFNQISKKNYLRI
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEHHHCCCCCCEEE
ICLDSPGVIGKIGDLFGKNDVSIESIVQLDASENKAEIVVITHEVSNGNFEKSKEGIRAL
EEECCCCCEEHHHHHCCCCCCCHHHHEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHCC
PEVELIASQLSCI
CHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]