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The map label for this gene is msrA [H]

Identifier: 123966271

GI number: 123966271

Start: 929713

End: 930441

Strand: Direct

Name: msrA [H]

Synonym: P9515_10381

Alternate gene names: 123966271

Gene position: 929713-930441 (Clockwise)

Preceding gene: 123966270

Following gene: 123966278

Centisome position: 54.55

GC content: 31.41

Gene sequence:

>729_bases
ATGTTTAAATTCCTAAAAAAAATCATGAATAAAAACGAAACAATTTCGGAAAATAAAAATAATTTCCTCCATAGAATACT
AAATACAAACATAAGAGAGGAACCTAATTCTCAAGAGGATTCAATAATATTTGGATGCGGGTGTTTCTGGGGGGCTGAAA
AATGTTTTTGGAAACTTCCTGGAATCGTTACAACTTCAGTAGGTTATGCGGGAGGAGAGAAGAAAAACCCTACATACTAT
GAAGTATGTTCAGGTATTACTGGTCATGCAGAAGTGGTTAAGGTGGTTTGGAATATCAATGAGTTAGATATAAGTGATTT
ATTAAAAATGTTTTGGGAATGTCATGATCCAACTCAAAAAAATAGACAAGGTAATGATATGGGAACTCAATATAGATCAA
CAATTTACTACACAAATAAAAATAGTAAAGACATAATTAACTTAAGCAAAGAAGCTTATCAAAAAGAGCTTACAGCTAAT
AATTTCGGGGAAATCGAAACAGAGATAAAAATGATTGACACTTATTATTATGCAGAAGAATATCACCAGCAATATTTAGC
TGTAGAGGGAAGTAGGCAATATTGTTCAGCATCACCAACTAAAGTAAAGTTGGGAAATTTTAATGGCAGCAATTACAGAC
TACCGAAAGAAATCTGGGATAATTTTAATTGGGACATAGATAAATGTGTATTGAGATCTAATAATAAACCTATAGAGATT
AACAAATGA

Upstream 100 bases:

>100_bases
AAAGATTTGATAAAAAGAAAAGGACTATATAAAAAACTTTGGGAAAGAGAAATAGCTACCAATAAAATAGTTAGTTAAAT
AAAATTATACTGATATTAAA

Downstream 100 bases:

>100_bases
GAGTCATTTATATTTATAGTATTGTTACGGGGCGTAGCGCAGTTTGGTAGCGCACCACTTTGGGGTAGTGGGGGTCGTGG
GTTCAAATCCCGCCGTTCCG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MFKFLKKIMNKNETISENKNNFLHRILNTNIREEPNSQEDSIIFGCGCFWGAEKCFWKLPGIVTTSVGYAGGEKKNPTYY
EVCSGITGHAEVVKVVWNINELDISDLLKMFWECHDPTQKNRQGNDMGTQYRSTIYYTNKNSKDIINLSKEAYQKELTAN
NFGEIETEIKMIDTYYYAEEYHQQYLAVEGSRQYCSASPTKVKLGNFNGSNYRLPKEIWDNFNWDIDKCVLRSNNKPIEI
NK

Sequences:

>Translated_242_residues
MFKFLKKIMNKNETISENKNNFLHRILNTNIREEPNSQEDSIIFGCGCFWGAEKCFWKLPGIVTTSVGYAGGEKKNPTYY
EVCSGITGHAEVVKVVWNINELDISDLLKMFWECHDPTQKNRQGNDMGTQYRSTIYYTNKNSKDIINLSKEAYQKELTAN
NFGEIETEIKMIDTYYYAEEYHQQYLAVEGSRQYCSASPTKVKLGNFNGSNYRLPKEIWDNFNWDIDKCVLRSNNKPIEI
NK
>Mature_242_residues
MFKFLKKIMNKNETISENKNNFLHRILNTNIREEPNSQEDSIIFGCGCFWGAEKCFWKLPGIVTTSVGYAGGEKKNPTYY
EVCSGITGHAEVVKVVWNINELDISDLLKMFWECHDPTQKNRQGNDMGTQYRSTIYYTNKNSKDIINLSKEAYQKELTAN
NFGEIETEIKMIDTYYYAEEYHQQYLAVEGSRQYCSASPTKVKLGNFNGSNYRLPKEIWDNFNWDIDKCVLRSNNKPIEI
NK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=177, Percent_Identity=51.9774011299435, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI208609995, Length=177, Percent_Identity=51.9774011299435, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI208609993, Length=116, Percent_Identity=52.5862068965517, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1790665, Length=165, Percent_Identity=47.2727272727273, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=35.9154929577465, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=173, Percent_Identity=36.9942196531792, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664627, Length=176, Percent_Identity=30.6818181818182, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24664631, Length=176, Percent_Identity=30.1136363636364, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45553131, Length=163, Percent_Identity=31.2883435582822, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 28178; Mature: 28178

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFLKKIMNKNETISENKNNFLHRILNTNIREEPNSQEDSIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHCC
GIVTTSVGYAGGEKKNPTYYEVCSGITGHAEVVKVVWNINELDISDLLKMFWECHDPTQK
CEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSTIYYTNKNSKDIINLSKEAYQKELTANNFGEIETEIKMIDTYYYAEE
CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YHQQYLAVEGSRQYCSASPTKVKLGNFNGSNYRLPKEIWDNFNWDIDKCVLRSNNKPIEI
HHHHHEEECCCCHHCCCCCCEEEEECCCCCCEECCHHHHCCCCCCHHHHHHHCCCCCEEE
NK
CC
>Mature Secondary Structure
MFKFLKKIMNKNETISENKNNFLHRILNTNIREEPNSQEDSIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHCC
GIVTTSVGYAGGEKKNPTYYEVCSGITGHAEVVKVVWNINELDISDLLKMFWECHDPTQK
CEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSTIYYTNKNSKDIINLSKEAYQKELTANNFGEIETEIKMIDTYYYAEE
CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YHQQYLAVEGSRQYCSASPTKVKLGNFNGSNYRLPKEIWDNFNWDIDKCVLRSNNKPIEI
HHHHHEEECCCCHHCCCCCCEEEEECCCCCCEECCHHHHCCCCCCHHHHHHHCCCCCEEE
NK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA