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The map label for this gene is ahpC [C]

Identifier: 123966166

GI number: 123966166

Start: 833665

End: 834249

Strand: Reverse

Name: ahpC [C]

Synonym: P9515_09331

Alternate gene names: 123966166

Gene position: 834249-833665 (Counterclockwise)

Preceding gene: 123966169

Following gene: 123966163

Centisome position: 48.95

GC content: 35.38

Gene sequence:

>585_bases
ATGAGTTTAAGAGTTGGCCAAGAAGCACCAAATTTCACTGCAACAGCAGTTTATGATCAAGAATTTAAAGAGATAACTCT
TTCAAGTTACAAAGGTAAGTGGGTTGTTTTATTCTTCTATCCACTAGATTTTACATTTGTATGTCCAACTGAAATTACTG
CCTTTAGTGATGAATACGAAAAATTTTCTGCATTAAATACCGAAATACTCGGAGTATCCGTAGATAGTAAGCATTGTCAT
TTAGCATGGATACAAACACCAAGAAATGAAGGTGGTATTGGTGATATTAATTATCCATTAGTTTCAGATTTAAAACGAGA
AATTTGCCAAGAATACAATGTTCTTAATGATGATGGAGAAGCAGATAGGGGTTTATTCCTTATTAATCCGCAAGGAATAG
TAATGCATACCACAGTAAATAAAGCACCTGTAGGACGTAATGTAGACGAAACGTTAAGGATACTTCAAGGCTACCAATAT
GTTGCAGCTAATCCTGATGAGGTCTGTCCCGCAAACTGGACTCCAGGAGAAAAAACAATGTTAGAAGATCCAAAAGGAAG
TAAAGAATACTTTTCTGCACTCTAG

Upstream 100 bases:

>100_bases
CAAATTATGGAATTTCTTGCTATATTATATACGTTTAATTTAACAATAAATAAGGTCTCCACGGCCTATAATTTTTTTCA
AAAAAAGGACTACAATTTCC

Downstream 100 bases:

>100_bases
ATATAATTATATATTTTAGATATAAATTTTATCTAATTTGAAATTATAAAATAATATAAAATAACCATTAAATAAAAAAA
TATAATTTTAACAAATGAAA

Product: thioredoxin peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSLRVGQEAPNFTATAVYDQEFKEITLSSYKGKWVVLFFYPLDFTFVCPTEITAFSDEYEKFSALNTEILGVSVDSKHCH
LAWIQTPRNEGGIGDINYPLVSDLKREICQEYNVLNDDGEADRGLFLINPQGIVMHTTVNKAPVGRNVDETLRILQGYQY
VAANPDEVCPANWTPGEKTMLEDPKGSKEYFSAL

Sequences:

>Translated_194_residues
MSLRVGQEAPNFTATAVYDQEFKEITLSSYKGKWVVLFFYPLDFTFVCPTEITAFSDEYEKFSALNTEILGVSVDSKHCH
LAWIQTPRNEGGIGDINYPLVSDLKREICQEYNVLNDDGEADRGLFLINPQGIVMHTTVNKAPVGRNVDETLRILQGYQY
VAANPDEVCPANWTPGEKTMLEDPKGSKEYFSAL
>Mature_193_residues
SLRVGQEAPNFTATAVYDQEFKEITLSSYKGKWVVLFFYPLDFTFVCPTEITAFSDEYEKFSALNTEILGVSVDSKHCHL
AWIQTPRNEGGIGDINYPLVSDLKREICQEYNVLNDDGEADRGLFLINPQGIVMHTTVNKAPVGRNVDETLRILQGYQYV
AANPDEVCPANWTPGEKTMLEDPKGSKEYFSAL

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=191, Percent_Identity=58.6387434554974, Blast_Score=233, Evalue=8e-62,
Organism=Homo sapiens, GI32455266, Length=191, Percent_Identity=58.6387434554974, Blast_Score=233, Evalue=8e-62,
Organism=Homo sapiens, GI32455264, Length=191, Percent_Identity=58.6387434554974, Blast_Score=233, Evalue=8e-62,
Organism=Homo sapiens, GI32189392, Length=190, Percent_Identity=57.8947368421053, Blast_Score=228, Evalue=2e-60,
Organism=Homo sapiens, GI5802974, Length=188, Percent_Identity=55.3191489361702, Blast_Score=221, Evalue=3e-58,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=53.125, Blast_Score=220, Evalue=5e-58,
Organism=Homo sapiens, GI32483377, Length=186, Percent_Identity=54.8387096774194, Blast_Score=218, Evalue=2e-57,
Organism=Homo sapiens, GI33188454, Length=88, Percent_Identity=65.9090909090909, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=27.8947368421053, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1786822, Length=181, Percent_Identity=38.6740331491713, Blast_Score=140, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI193204376, Length=188, Percent_Identity=54.2553191489362, Blast_Score=214, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI32565831, Length=188, Percent_Identity=54.2553191489362, Blast_Score=214, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=50, Blast_Score=198, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25153706, Length=200, Percent_Identity=28, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323613, Length=194, Percent_Identity=48.9690721649485, Blast_Score=194, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6320661, Length=192, Percent_Identity=48.9583333333333, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319407, Length=189, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24656348, Length=189, Percent_Identity=51.8518518518518, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17864676, Length=189, Percent_Identity=51.8518518518518, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17157991, Length=189, Percent_Identity=52.3809523809524, Blast_Score=209, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24641739, Length=189, Percent_Identity=52.3809523809524, Blast_Score=209, Evalue=9e-55,
Organism=Drosophila melanogaster, GI17738015, Length=194, Percent_Identity=51.0309278350515, Blast_Score=208, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=45.2631578947368, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=33.8624338624339, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=33.8624338624339, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=33.8624338624339, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24581278, Length=190, Percent_Identity=28.9473684210526, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21830; Mature: 21699

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRVGQEAPNFTATAVYDQEFKEITLSSYKGKWVVLFFYPLDFTFVCPTEITAFSDEYE
CCCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCHHHCCHHHH
KFSALNTEILGVSVDSKHCHLAWIQTPRNEGGIGDINYPLVSDLKREICQEYNVLNDDGE
HHHHCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ADRGLFLINPQGIVMHTTVNKAPVGRNVDETLRILQGYQYVAANPDEVCPANWTPGEKTM
CCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCC
LEDPKGSKEYFSAL
CCCCCCCHHHHHCC
>Mature Secondary Structure 
SLRVGQEAPNFTATAVYDQEFKEITLSSYKGKWVVLFFYPLDFTFVCPTEITAFSDEYE
CCCCCCCCCCCEEEEEECHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCHHHCCHHHH
KFSALNTEILGVSVDSKHCHLAWIQTPRNEGGIGDINYPLVSDLKREICQEYNVLNDDGE
HHHHCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
ADRGLFLINPQGIVMHTTVNKAPVGRNVDETLRILQGYQYVAANPDEVCPANWTPGEKTM
CCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCC
LEDPKGSKEYFSAL
CCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]