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The map label for this gene is csgA [H]

Identifier: 123966112

GI number: 123966112

Start: 788872

End: 789537

Strand: Reverse

Name: csgA [H]

Synonym: P9515_08791

Alternate gene names: 123966112

Gene position: 789537-788872 (Counterclockwise)

Preceding gene: 123966121

Following gene: 123966105

Centisome position: 46.33

GC content: 34.53

Gene sequence:

>666_bases
ATGTCTTGTTATCTTATTACAGGCTCAAATAGGGGAATTGGCCTGGAACTATGCAAACAACTAGTTGAAAGAGGAGATAA
AGTAATAGCCACCTGTAGAAAGGCTTCTGCAGAATTAAAAAACTTAAGTGTACGAATTGAGGAGGAAGTTGACATTACTT
CTGAAAATTCCATAAATAGTTTGAGAGAAAATTTATCAGGGATCCAATTAGATTGCTTAATTCATAATGCAGGTATTTAT
GAATTTAATTCAATTGATGATTTGGATCAAGAAAGTGTAATTCGTCAATTTGTAGTAAATGCATTGAGTCCACTATCTAT
GACTAAATCTCTGAAAGGTTTTTTAAAAAAATCTTCAAAGATTGGATTTATCACAAGTCGAATGGGTTCTATAGGTGATA
ATTCATCTGGTAGTTCATATGGCTATAGGATGTCCAAAGTTGCCTTATCTATGGCGGCGAAATCGCTTTCAAGAGATTTG
TTAAAAGAAGAAATCTACGTTGCTATTTTACATCCAGGCTTAGTAAGTACGCGTATGACTGGATTTACTAAGAACGGTAT
ATCTACAGAAGAATCTGCCAATGGACTTTTAAAACGCATTGACTCTCTTAATAGGAACAATACTGGAACTTTTTGGCACA
CGAATGGAGAGATCTTGCCTTGGTAA

Upstream 100 bases:

>100_bases
CTAATTATAGCTAAAAACTTTTTTTCACTTTATGAAAAAATTTACTTTCTTTTTTTTTAAGTAACAGAATTATAATATTT
ATAATAAATTATTTGGATAA

Downstream 100 bases:

>100_bases
ATTCAACTTAAATTTCTCACTTTTTATAATTTTGATTTGTTAAAAAAGCTTTAAATTTTGATTAATTTAGTTTCTTTGTT
TTACGGTTTTAGTTATGTTG

Product: short-chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSCYLITGSNRGIGLELCKQLVERGDKVIATCRKASAELKNLSVRIEEEVDITSENSINSLRENLSGIQLDCLIHNAGIY
EFNSIDDLDQESVIRQFVVNALSPLSMTKSLKGFLKKSSKIGFITSRMGSIGDNSSGSSYGYRMSKVALSMAAKSLSRDL
LKEEIYVAILHPGLVSTRMTGFTKNGISTEESANGLLKRIDSLNRNNTGTFWHTNGEILPW

Sequences:

>Translated_221_residues
MSCYLITGSNRGIGLELCKQLVERGDKVIATCRKASAELKNLSVRIEEEVDITSENSINSLRENLSGIQLDCLIHNAGIY
EFNSIDDLDQESVIRQFVVNALSPLSMTKSLKGFLKKSSKIGFITSRMGSIGDNSSGSSYGYRMSKVALSMAAKSLSRDL
LKEEIYVAILHPGLVSTRMTGFTKNGISTEESANGLLKRIDSLNRNNTGTFWHTNGEILPW
>Mature_220_residues
SCYLITGSNRGIGLELCKQLVERGDKVIATCRKASAELKNLSVRIEEEVDITSENSINSLRENLSGIQLDCLIHNAGIYE
FNSIDDLDQESVIRQFVVNALSPLSMTKSLKGFLKKSSKIGFITSRMGSIGDNSSGSSYGYRMSKVALSMAAKSLSRDLL
KEEIYVAILHPGLVSTRMTGFTKNGISTEESANGLLKRIDSLNRNNTGTFWHTNGEILPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=197, Percent_Identity=28.9340101522843, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17558996, Length=246, Percent_Identity=30.0813008130081, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI72001658, Length=244, Percent_Identity=34.0163934426229, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17559962, Length=247, Percent_Identity=34.412955465587, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559964, Length=243, Percent_Identity=32.9218106995885, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193207563, Length=239, Percent_Identity=27.1966527196653, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17542178, Length=237, Percent_Identity=32.9113924050633, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17558990, Length=249, Percent_Identity=27.710843373494, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17558994, Length=240, Percent_Identity=29.5833333333333, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17558992, Length=240, Percent_Identity=30.8333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541382, Length=251, Percent_Identity=29.0836653386454, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17558006, Length=202, Percent_Identity=31.6831683168317, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=244, Percent_Identity=28.2786885245902, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322227, Length=220, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24640547, Length=248, Percent_Identity=30.241935483871, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24643142, Length=181, Percent_Identity=32.0441988950276, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24304; Mature: 24173

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCYLITGSNRGIGLELCKQLVERGDKVIATCRKASAELKNLSVRIEEEVDITSENSINS
CEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHH
LRENLSGIQLDCLIHNAGIYEFNSIDDLDQESVIRQFVVNALSPLSMTKSLKGFLKKSSK
HHHHHCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
IGFITSRMGSIGDNSSGSSYGYRMSKVALSMAAKSLSRDLLKEEIYVAILHPGLVSTRMT
CEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHC
GFTKNGISTEESANGLLKRIDSLNRNNTGTFWHTNGEILPW
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCEECC
>Mature Secondary Structure 
SCYLITGSNRGIGLELCKQLVERGDKVIATCRKASAELKNLSVRIEEEVDITSENSINS
EEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHH
LRENLSGIQLDCLIHNAGIYEFNSIDDLDQESVIRQFVVNALSPLSMTKSLKGFLKKSSK
HHHHHCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
IGFITSRMGSIGDNSSGSSYGYRMSKVALSMAAKSLSRDLLKEEIYVAILHPGLVSTRMT
CEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHC
GFTKNGISTEESANGLLKRIDSLNRNNTGTFWHTNGEILPW
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]