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The map label for this gene is lig [H]

Identifier: 123966092

GI number: 123966092

Start: 772900

End: 774537

Strand: Direct

Name: lig [H]

Synonym: P9515_08591

Alternate gene names: 123966092

Gene position: 772900-774537 (Clockwise)

Preceding gene: 123966091

Following gene: 123966093

Centisome position: 45.35

GC content: 26.5

Gene sequence:

>1638_bases
ATGAGCCTAAAAAAGTTTTCAGAATTATATTTAGATTTAGATTCTTGTAATAGTACAAATAAAAAGATTGAAATCTTAAA
TAATTATTTTTCTTCTAATGAAGATTTAGAAAACGCATGGACAATTTATTTACTAACAGGGAAAAAAAATAAAAGATTTA
TAAGTGGATCATTACTTAAAACTTTATTTTCGGAAATTTATGAATATCCTTTATGGTTAATTGATTCATGTTATTTAAAA
GTTGGAGATTCTTCTGAAGTTATATCCTTATTATTGAGGAATAAGATCATTGGAAGAAATTATAAATATCAAAATATCTC
GCTTAATGAATTATTAAATAAATTTCTTCCTGATTTATATATTCTGAAAGAAGAAGATAAGAAGTTAAGGTTGAAAGAAA
TTTGGGAAAATATTCCAAAAGAAAACCATTTAGTTATTAACAAAATCTTAACTGGTACTTTTAGAGTTGGAGTATCAATA
GGCTTAATAACAAAATCTATAGCAAAGTTAATTAATTTAGAAGAGGCAATCATTTCTCATAGATTAATGGGTGATTTTAT
TCCCTCTCCTGAAACATATCAATTATTAATAAGTAAAAAAATAAATCCTTCAGAATTAAATTACAAACCTTATCCATTTC
TACTTGCTAATACTTTTGACAAGAAAATTATAGATAAATCAATTAATGATTTTCAATTTGAATGGAAATGGGATGGAATT
AGAATTCAATTAATAAAAAGGGATGGTAAAATTTCAATATGGTCAAGAGGCCAGGAATTAGTAAATAAATCTTTTCCTGA
ATTAGTAGAGAAAATAGTATTTATCAAGGATGACTTTGTAGTAGATGGTGAATTATTAGTTTGGAATTCTATCGAAGATC
TTCCTATGAATTTCTCACTACTTCAAAAAAGACTTAATAGAAAAGAACCTTCGAGAAAAATTCAAAAAAGTTTTCCTATT
ACATTTATTGCCTATGATCTTTTGGAAATAGATGGAGAAGATCAAAGAGAGTTTAATCTAAAAAATAGAAGAATTAATTT
AGAAAATAATTTCTATAAATGGTTAAATGAAAGTGAAGAGGACCTCTCAAATATTTTTAAAATAAGTAAATTAATATATC
CAAAAAATTGGAAAGAAGCAGAGATGTTTAAAAATAATTCTAGAGATAATGGTACAGAGGGATTAGTCATTAAAAATAAA
AACTCAAACTATTCTCCAGGAAGGAAGAAAGGGCTTTGGTGGAAATATAAAGTTGATCCAATGCAACTTGATGCAGTATT
GATCTATGCCAAAGGAGGTACTGGAATAAGAGCAGGTTTATATACTGACTATAGTTTTGGTCTGTGGAAAGATGGAGAAT
TAATAAAATTTGCAAGTGCATATTCTGGTTTAAATAATACTGAGATTAAAGAACTAGATAAATGGATAAGACAAAATACT
ATCGAAAGATTTGGACCTGTAAGATCTGTAAAACCTAAAATGGTCTTCGAAATTTCTTTCGAAAACATTCAAAGATCAAA
ACGTCATAAATCAGGAATTGCCGTTAGATTTCCTAGAATTACAAAATGGAGAAAAGATAAATTTATACAAGATGCTGACA
CCTTAGAAAATGCTCAAAAACTAATTCTAAGTGAATAA

Upstream 100 bases:

>100_bases
AAGCTAAAAATGTTTTTTTCCATCATGGAGATAGTGAAGTTTTAATTAAATATTTAAAAGAAAAAAAATCTATCAATGTT
CTTGAATTTGAATATAAAAA

Downstream 100 bases:

>100_bases
TGGAAAGGTTCTCAAATAAATCTTCTATAAATTACATAAGAAAATTTTTTAATAAAAATGGTTGGGACCCTCTGCCATAT
CAAATAGAATCGTGGGAAGC

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MSLKKFSELYLDLDSCNSTNKKIEILNNYFSSNEDLENAWTIYLLTGKKNKRFISGSLLKTLFSEIYEYPLWLIDSCYLK
VGDSSEVISLLLRNKIIGRNYKYQNISLNELLNKFLPDLYILKEEDKKLRLKEIWENIPKENHLVINKILTGTFRVGVSI
GLITKSIAKLINLEEAIISHRLMGDFIPSPETYQLLISKKINPSELNYKPYPFLLANTFDKKIIDKSINDFQFEWKWDGI
RIQLIKRDGKISIWSRGQELVNKSFPELVEKIVFIKDDFVVDGELLVWNSIEDLPMNFSLLQKRLNRKEPSRKIQKSFPI
TFIAYDLLEIDGEDQREFNLKNRRINLENNFYKWLNESEEDLSNIFKISKLIYPKNWKEAEMFKNNSRDNGTEGLVIKNK
NSNYSPGRKKGLWWKYKVDPMQLDAVLIYAKGGTGIRAGLYTDYSFGLWKDGELIKFASAYSGLNNTEIKELDKWIRQNT
IERFGPVRSVKPKMVFEISFENIQRSKRHKSGIAVRFPRITKWRKDKFIQDADTLENAQKLILSE

Sequences:

>Translated_545_residues
MSLKKFSELYLDLDSCNSTNKKIEILNNYFSSNEDLENAWTIYLLTGKKNKRFISGSLLKTLFSEIYEYPLWLIDSCYLK
VGDSSEVISLLLRNKIIGRNYKYQNISLNELLNKFLPDLYILKEEDKKLRLKEIWENIPKENHLVINKILTGTFRVGVSI
GLITKSIAKLINLEEAIISHRLMGDFIPSPETYQLLISKKINPSELNYKPYPFLLANTFDKKIIDKSINDFQFEWKWDGI
RIQLIKRDGKISIWSRGQELVNKSFPELVEKIVFIKDDFVVDGELLVWNSIEDLPMNFSLLQKRLNRKEPSRKIQKSFPI
TFIAYDLLEIDGEDQREFNLKNRRINLENNFYKWLNESEEDLSNIFKISKLIYPKNWKEAEMFKNNSRDNGTEGLVIKNK
NSNYSPGRKKGLWWKYKVDPMQLDAVLIYAKGGTGIRAGLYTDYSFGLWKDGELIKFASAYSGLNNTEIKELDKWIRQNT
IERFGPVRSVKPKMVFEISFENIQRSKRHKSGIAVRFPRITKWRKDKFIQDADTLENAQKLILSE
>Mature_544_residues
SLKKFSELYLDLDSCNSTNKKIEILNNYFSSNEDLENAWTIYLLTGKKNKRFISGSLLKTLFSEIYEYPLWLIDSCYLKV
GDSSEVISLLLRNKIIGRNYKYQNISLNELLNKFLPDLYILKEEDKKLRLKEIWENIPKENHLVINKILTGTFRVGVSIG
LITKSIAKLINLEEAIISHRLMGDFIPSPETYQLLISKKINPSELNYKPYPFLLANTFDKKIIDKSINDFQFEWKWDGIR
IQLIKRDGKISIWSRGQELVNKSFPELVEKIVFIKDDFVVDGELLVWNSIEDLPMNFSLLQKRLNRKEPSRKIQKSFPIT
FIAYDLLEIDGEDQREFNLKNRRINLENNFYKWLNESEEDLSNIFKISKLIYPKNWKEAEMFKNNSRDNGTEGLVIKNKN
SNYSPGRKKGLWWKYKVDPMQLDAVLIYAKGGTGIRAGLYTDYSFGLWKDGELIKFASAYSGLNNTEIKELDKWIRQNTI
ERFGPVRSVKPKMVFEISFENIQRSKRHKSGIAVRFPRITKWRKDKFIQDADTLENAQKLILSE

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=337, Percent_Identity=25.2225519287834, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71985269, Length=337, Percent_Identity=28.486646884273, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320038, Length=526, Percent_Identity=22.0532319391635, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24762424, Length=334, Percent_Identity=24.251497005988, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI85815841, Length=344, Percent_Identity=24.7093023255814, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 64000; Mature: 63868

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKKFSELYLDLDSCNSTNKKIEILNNYFSSNEDLENAWTIYLLTGKKNKRFISGSLLK
CCHHHHHHHHEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEECHHHHH
TLFSEIYEYPLWLIDSCYLKVGDSSEVISLLLRNKIIGRNYKYQNISLNELLNKFLPDLY
HHHHHHHHCHHHHEEEHEEEECCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHCCCEE
ILKEEDKKLRLKEIWENIPKENHLVINKILTGTFRVGVSIGLITKSIAKLINLEEAIISH
EEECCCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHH
RLMGDFIPSPETYQLLISKKINPSELNYKPYPFLLANTFDKKIIDKSINDFQFEWKWDGI
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCEEEEEECCE
RIQLIKRDGKISIWSRGQELVNKSFPELVEKIVFIKDDFVVDGELLVWNSIEDLPMNFSL
EEEEEECCCCEEEECCCHHHHHCHHHHHHHHHHEEECCEEECCCEEEECCCCCCCCCHHH
LQKRLNRKEPSRKIQKSFPITFIAYDLLEIDGEDQREFNLKNRRINLENNFYKWLNESEE
HHHHHCCCCHHHHHHHHCCEEEEEEEHHHCCCCCCHHCCCCCCEECCCCHHHHHCCCCHH
DLSNIFKISKLIYPKNWKEAEMFKNNSRDNGTEGLVIKNKNSNYSPGRKKGLWWKYKVDP
HHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCC
MQLDAVLIYAKGGTGIRAGLYTDYSFGLWKDGELIKFASAYSGLNNTEIKELDKWIRQNT
EEEEEEEEEECCCCCEEECEEECCCCCCCCCCCEEEEHHHHCCCCCCHHHHHHHHHHHHH
IERFGPVRSVKPKMVFEISFENIQRSKRHKSGIAVRFPRITKWRKDKFIQDADTLENAQK
HHHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCHHHHHHHHH
LILSE
HHCCC
>Mature Secondary Structure 
SLKKFSELYLDLDSCNSTNKKIEILNNYFSSNEDLENAWTIYLLTGKKNKRFISGSLLK
CHHHHHHHHEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEECHHHHH
TLFSEIYEYPLWLIDSCYLKVGDSSEVISLLLRNKIIGRNYKYQNISLNELLNKFLPDLY
HHHHHHHHCHHHHEEEHEEEECCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHCCCEE
ILKEEDKKLRLKEIWENIPKENHLVINKILTGTFRVGVSIGLITKSIAKLINLEEAIISH
EEECCCCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHH
RLMGDFIPSPETYQLLISKKINPSELNYKPYPFLLANTFDKKIIDKSINDFQFEWKWDGI
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCEEEEEECCE
RIQLIKRDGKISIWSRGQELVNKSFPELVEKIVFIKDDFVVDGELLVWNSIEDLPMNFSL
EEEEEECCCCEEEECCCHHHHHCHHHHHHHHHHEEECCEEECCCEEEECCCCCCCCCHHH
LQKRLNRKEPSRKIQKSFPITFIAYDLLEIDGEDQREFNLKNRRINLENNFYKWLNESEE
HHHHHCCCCHHHHHHHHCCEEEEEEEHHHCCCCCCHHCCCCCCEECCCCHHHHHCCCCHH
DLSNIFKISKLIYPKNWKEAEMFKNNSRDNGTEGLVIKNKNSNYSPGRKKGLWWKYKVDP
HHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCC
MQLDAVLIYAKGGTGIRAGLYTDYSFGLWKDGELIKFASAYSGLNNTEIKELDKWIRQNT
EEEEEEEEEECCCCCEEECEEECCCCCCCCCCCEEEEHHHHCCCCCCHHHHHHHHHHHHH
IERFGPVRSVKPKMVFEISFENIQRSKRHKSGIAVRFPRITKWRKDKFIQDADTLENAQK
HHHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCHHHHHHHHH
LILSE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA