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The map label for this gene is thrB [H]

Identifier: 123965895

GI number: 123965895

Start: 595280

End: 596227

Strand: Reverse

Name: thrB [H]

Synonym: P9515_06601

Alternate gene names: 123965895

Gene position: 596227-595280 (Counterclockwise)

Preceding gene: 123965896

Following gene: 123965894

Centisome position: 34.99

GC content: 39.35

Gene sequence:

>948_bases
ATGTCTATACCCAATTTAGGTAAAAAAATTATAGTTACAGTTCCTTCTACAACTGCTAATTTAGGTCCCGGATTTGATTG
TCTGGGAGCAGCCTTAGACTTATATAATGAATTTATATTCACAAGAATAGAAGGTGATGGAGATAGATTTGATTTAATCA
TGGAGAGTACAGACGGCAATCATTTGAGAGGAGGTCCTGAGAACTTAGTCTTTCGAGCGGCACAAAAAGTATGGGAGAGT
GCAGATGTATCCCCATTCGCTCTTGAGGCAAGAGTTAAACTTGCAGTCCCCCCAGCTCGTGGACTAGGTAGTAGTGCAAC
TGCCATTGTTGCAGGGCTTATTGGAGCCAATGCGATCATGAACTCCCCACTTCCTAAAGAAAAACTCTTAGAACTTGCGA
TCGATATAGAAGGTCATCCTGACAATGTAGTTCCATCTCTTTTAGGTGGTTTATGTTTAACAGCAAGATCATCTTCCCAA
AGATGGAGAATTATTAGATGTGATTGGCATGATTCGATAAAAGCAGTTATAGCTATACCCGCAATTCGACTTAGCACAAG
CGAAGCAAGAAGAGTGATGCCAAAAAATATTCCAATATCTGATGCCGTTACAAACATGGGTGCCCTTACTTTATTACTTA
ATGGTTTAAAAACTGGAAATGATGAGCTAATAAAAGAGGGTATGTTTGATAAATTACATGAGCCATATCGCTGGAAACTA
ATTAAAGGAGGATTAGAAGTTAAAGAGGCTGCATTACAAGCAGGAGCTTTAGGTTGCGCAATTAGTGGAGCTGGGCCAAG
CATTTTAGCTTTATGTAAAAGTAATAATGGCAAGGTAGTAAGTCAGGCGATGGTAAAAGCTTGGGAAAACTTAGGCATTG
CAAGTAGAGCTCCATTTTTAAATGTCCAAACGAAGGGGAGTCAATTCAAAACTATTTCAGGTAAGTAG

Upstream 100 bases:

>100_bases
TTAAATCTATTCCTATTAAAATAATTTTAGATGAAGAGTTTGGACTTTATAGTGCAGCCTGCAGAGCAAAAATGCTATTA
AAAACAACATAACCCTAAGA

Downstream 100 bases:

>100_bases
TTTTACTTACACTTTTTAATGTTAAAGTCTCAAGCTGGAGTATCTTCAACTACAATAAAAAAATTGTTCATTACATAAAT
GAATTTAGAATCTTTTCCTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSIPNLGKKIIVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGDGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWES
ADVSPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQ
RWRIIRCDWHDSIKAVIAIPAIRLSTSEARRVMPKNIPISDAVTNMGALTLLLNGLKTGNDELIKEGMFDKLHEPYRWKL
IKGGLEVKEAALQAGALGCAISGAGPSILALCKSNNGKVVSQAMVKAWENLGIASRAPFLNVQTKGSQFKTISGK

Sequences:

>Translated_315_residues
MSIPNLGKKIIVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGDGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWES
ADVSPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQ
RWRIIRCDWHDSIKAVIAIPAIRLSTSEARRVMPKNIPISDAVTNMGALTLLLNGLKTGNDELIKEGMFDKLHEPYRWKL
IKGGLEVKEAALQAGALGCAISGAGPSILALCKSNNGKVVSQAMVKAWENLGIASRAPFLNVQTKGSQFKTISGK
>Mature_314_residues
SIPNLGKKIIVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGDGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWESA
DVSPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQR
WRIIRCDWHDSIKAVIAIPAIRLSTSEARRVMPKNIPISDAVTNMGALTLLLNGLKTGNDELIKEGMFDKLHEPYRWKLI
KGGLEVKEAALQAGALGCAISGAGPSILALCKSNNGKVVSQAMVKAWENLGIASRAPFLNVQTKGSQFKTISGK

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=276, Percent_Identity=30.7971014492754, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321814, Length=334, Percent_Identity=30.8383233532934, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33544; Mature: 33413

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPNLGKKIIVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGDGDRFDLIMESTDGN
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCC
HLRGGPENLVFRAAQKVWESADVSPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIM
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQRWRIIRCDWHDSIKAVIAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHHHHEEEECCCCCCEEEEEECCCCCCEEEEEEC
AIRLSTSEARRVMPKNIPISDAVTNMGALTLLLNGLKTGNDELIKEGMFDKLHEPYRWKL
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
IKGGLEVKEAALQAGALGCAISGAGPSILALCKSNNGKVVSQAMVKAWENLGIASRAPFL
EECCCHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEE
NVQTKGSQFKTISGK
EEEECCCEEEECCCC
>Mature Secondary Structure 
SIPNLGKKIIVTVPSTTANLGPGFDCLGAALDLYNEFIFTRIEGDGDRFDLIMESTDGN
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCC
HLRGGPENLVFRAAQKVWESADVSPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIM
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQRWRIIRCDWHDSIKAVIAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHHHHEEEECCCCCCEEEEEECCCCCCEEEEEEC
AIRLSTSEARRVMPKNIPISDAVTNMGALTLLLNGLKTGNDELIKEGMFDKLHEPYRWKL
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
IKGGLEVKEAALQAGALGCAISGAGPSILALCKSNNGKVVSQAMVKAWENLGIASRAPFL
EECCCHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEE
NVQTKGSQFKTISGK
EEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA