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The map label for this gene is ndhD1 [H]

Identifier: 123965894

GI number: 123965894

Start: 593663

End: 595201

Strand: Reverse

Name: ndhD1 [H]

Synonym: P9515_06591

Alternate gene names: 123965894

Gene position: 595201-593663 (Counterclockwise)

Preceding gene: 123965895

Following gene: 123965893

Centisome position: 34.93

GC content: 34.76

Gene sequence:

>1539_bases
ATGAATTTAGAATCTTTTCCTTGGTTATCATCTATTGTTTTATTACCTTTGATTGGGGCGTTAATAATGCCTTTTTTAAA
AACAAATGAGGGAGAAGATAATTCTCTTCCAAGAAATATATCTTTAGGTTTTTTATTTATAGATTTTTTACTCATTGTAG
GTGTATTACTTCAGAAATTTGACAATACTGATAGTTCATTACAGTTGTTAGAAAGATTATCTTGGCTACCTTCCATAGGC
TTGGAATGGTCTCTTGGGGTAGATGGCCTCTCGGCTCCTTTAATCGCTTTAAGCGGATTAATTACGTTTTTATCAGCTGC
AGCAAGTTGGAAAGTAAAGAAAAAAGCAAATTTATATTTTGCATTACTTTTAGTTCAGGCCTCAGCACAGGCATTGGTAT
TCCTTTCTCAAGATTTCTTATTATTTTTCTTGGCATGGGAATTAGAACTCGTCCCTGTTTATCTTCTGATTGCTATTTGG
GGAGGTAAAAAGAGACTTTATGCTGCTACGAAATTTATACTTTATACTGCTTTAGCTTCTTTATTAATCCTTATAAGTGG
ATTAGCATTAGCACTGAGCGGGGATACTTTTACCTTAAATTTAAGTGAACTAACTAATAAACATGCACAAGGAAGTCTTG
CATTACTCTCTTATTTAGGCTTTTTAATAGGGTTTGGAGTTAAACTCCCTATTTTCCCTCTACATACATGGTTACCCGAC
GCTCATGGTGAAGCTAATGCTCCTGTTTCAATGCTTCTCGCTGGGATTCTTTTGAAGATGGGTGGCTATGCACTCTTAAG
ATTTAATGTTCAAATCTTACCTGAAGTACATCTTAAACTTGCACCAGCTTTAATTATTCTTGGAATAATTAACATAATTT
ATGGAGCATTAAATGCATTTGCTCAAGATAATGTTAAAAGAAGAATTGCATGTAGTTCAGTAAGTCATATGGGATTTGTA
CTTTTAGGAATCGGTGCAGTAGATGCTTTAGGTATAAGCGGTGCAATGCTACAAATGATTAGCCATGGTCTTATAGCTGC
AGCTATGTTTTTCGTAACTGGATCTTTTTATGAAAGGACAAATACCCTTTCGATTCCTAACATGGGGGGTTTAGCAAAAG
TTTTACCCATAACATTTGCTTTTTTCCTTGCTAGCTCTTTAGCATCTTTAGCACTACCAGGGATGAGTGGCTTTATAAGT
GAAATTACTGTATTTTTGGGAATCACAAGTCAAGAAGGCTTTAGCTCACTCTTTAGATCAATAACGATTCTTATAGCAGC
TATTGGTTTAGTTTTAACGCCCATATATCTTCTCTCTATGTGTAGAAGAGTATTTTTTGGGCCTAGGATCCCAGCACTTG
CTTCTGTCAAAGAAATGAATGGGAGAGAATTAACTATTGGTTTTAGTTTGCTTTTACCTACTCTGGTTATAGGTTTTTGG
CCAAAAATAGCAATAAATTTATATGAATCTTCCACAGATGCTCTCAGTCAACAACTGACTTTAGCTAAATTAGTTGGGTT
AATTTCAAACATCACTTAA

Upstream 100 bases:

>100_bases
CAAAACTATTTCAGGTAAGTAGTTTTACTTACACTTTTTAATGTTAAAGTCTCAAGCTGGAGTATCTTCAACTACAATAA
AAAAATTGTTCATTACATAA

Downstream 100 bases:

>100_bases
TTTTAATATTCAAAAAAATGGAAACTTCAATTTTTAATTATGGAGAATTGCCAGAATTTAAAAAATTTACATCAGATAGA
ATTAATAAAGAATTTCCAAG

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MNLESFPWLSSIVLLPLIGALIMPFLKTNEGEDNSLPRNISLGFLFIDFLLIVGVLLQKFDNTDSSLQLLERLSWLPSIG
LEWSLGVDGLSAPLIALSGLITFLSAAASWKVKKKANLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKRLYAATKFILYTALASLLILISGLALALSGDTFTLNLSELTNKHAQGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLKLAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSLFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALASVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTDALSQQLTLAKLVGLISNIT

Sequences:

>Translated_512_residues
MNLESFPWLSSIVLLPLIGALIMPFLKTNEGEDNSLPRNISLGFLFIDFLLIVGVLLQKFDNTDSSLQLLERLSWLPSIG
LEWSLGVDGLSAPLIALSGLITFLSAAASWKVKKKANLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKRLYAATKFILYTALASLLILISGLALALSGDTFTLNLSELTNKHAQGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLKLAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSLFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALASVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTDALSQQLTLAKLVGLISNIT
>Mature_512_residues
MNLESFPWLSSIVLLPLIGALIMPFLKTNEGEDNSLPRNISLGFLFIDFLLIVGVLLQKFDNTDSSLQLLERLSWLPSIG
LEWSLGVDGLSAPLIALSGLITFLSAAASWKVKKKANLYFALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIW
GGKKRLYAATKFILYTALASLLILISGLALALSGDTFTLNLSELTNKHAQGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLKLAPALIILGIINIIYGALNAFAQDNVKRRIACSSVSHMGFV
LLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERTNTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFIS
EITVFLGITSQEGFSSLFRSITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALASVKEMNGRELTIGFSLLLPTLVIGFW
PKIAINLYESSTDALSQQLTLAKLVGLISNIT

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=379, Percent_Identity=31.3984168865435, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI251831117, Length=357, Percent_Identity=26.0504201680672, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=512, Percent_Identity=37.6953125, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788831, Length=346, Percent_Identity=27.7456647398844, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788827, Length=302, Percent_Identity=28.476821192053, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788829, Length=296, Percent_Identity=28.3783783783784, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788614, Length=468, Percent_Identity=26.4957264957265, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI2367154, Length=219, Percent_Identity=30.5936073059361, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693160, Length=398, Percent_Identity=27.6381909547739, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 55241; Mature: 55241

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLESFPWLSSIVLLPLIGALIMPFLKTNEGEDNSLPRNISLGFLFIDFLLIVGVLLQKF
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DNTDSSLQLLERLSWLPSIGLEWSLGVDGLSAPLIALSGLITFLSAAASWKVKKKANLYF
CCCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHH
ALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKKRLYAATKFILYTALAS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LLILISGLALALSGDTFTLNLSELTNKHAQGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
HHHHHHHHHHEECCCEEEEEHHHHHCHHCCCHHHHHHHHHHHHHCCCCCCCEEHHHHCCC
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLKLAPALIILGIINIIYGALNAF
CCCCCCCCHHHHHHHHHHHHCCEEEEEEEHEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDNVKRRIACSSVSHMGFVLLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFISEITVFLGITSQEGFSSLFRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALASVKEMNGRELTIGFSLLLPTLVIGFW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCC
PKIAINLYESSTDALSQQLTLAKLVGLISNIT
HHHEEEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLESFPWLSSIVLLPLIGALIMPFLKTNEGEDNSLPRNISLGFLFIDFLLIVGVLLQKF
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DNTDSSLQLLERLSWLPSIGLEWSLGVDGLSAPLIALSGLITFLSAAASWKVKKKANLYF
CCCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHH
ALLLVQASAQALVFLSQDFLLFFLAWELELVPVYLLIAIWGGKKRLYAATKFILYTALAS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LLILISGLALALSGDTFTLNLSELTNKHAQGSLALLSYLGFLIGFGVKLPIFPLHTWLPD
HHHHHHHHHHEECCCEEEEEHHHHHCHHCCCHHHHHHHHHHHHHCCCCCCCEEHHHHCCC
AHGEANAPVSMLLAGILLKMGGYALLRFNVQILPEVHLKLAPALIILGIINIIYGALNAF
CCCCCCCCHHHHHHHHHHHHCCEEEEEEEHEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDNVKRRIACSSVSHMGFVLLGIGAVDALGISGAMLQMISHGLIAAAMFFVTGSFYERT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFISEITVFLGITSQEGFSSLFRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
ITILIAAIGLVLTPIYLLSMCRRVFFGPRIPALASVKEMNGRELTIGFSLLLPTLVIGFW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCC
PKIAINLYESSTDALSQQLTLAKLVGLISNIT
HHHEEEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA