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The map label for this gene is prlC [H]

Identifier: 123965893

GI number: 123965893

Start: 591543

End: 593645

Strand: Reverse

Name: prlC [H]

Synonym: P9515_06581

Alternate gene names: 123965893

Gene position: 593645-591543 (Counterclockwise)

Preceding gene: 123965894

Following gene: 123965888

Centisome position: 34.83

GC content: 31.38

Gene sequence:

>2103_bases
ATGGAAACTTCAATTTTTAATTATGGAGAATTGCCAGAATTTAAAAAATTTACATCAGATAGAATTAATAAAGAATTTCC
AAGTGTAATAGATAAAATAAATCTTGAATTCAAGAATATAGAAAACTTTTTATCTAATTACTTGAACCAAAAGAATCTTG
ATTGGGACAAGGTGATCAATCCTCTAAATGAAGTCAATGAGATTCTTAGGTGGAGCTGGGGAGTTATAAGTCATCTAAAT
GGAGTAAAAAATTCCGAAAGTTTAAGAGAAATTTACTCAAAATTTTTACCTGAAATTATTAATTTAAGTAATAAGTTTGG
ACAAAGTAAAATTATTTATAAAGCATTAGTAAAGCTTAAAGAAACAAATAATTTTGATAAAGTCAAAAGTAGAATCCTTG
ATAAAGAAATCCTCGAAATGGAACATCGAGGAATTTCATTAAATATAGATGACCAAAAAGAATTCAATGTTATTTCTGAA
AAGCTTGGAAAATTATCTACAAATTTCAGTAATAATGTCTTAGATGCAACTAATGCTTGGTTTTTAATATTAAATGATAA
ATCTCAAATAGAGGGACTGCCAGAAAGGGTTTTAGAATTAATGTCTATATCAGCTCATGAATATTTAAAAAAAGAAGGCG
AAGCTGATCCAAAAAATGGGCCTTGGAAATTAAGTTTAGATATTCCCACCTATACCGCATTTATGACATATGCAAAAGAT
CGTAATCTAAGGGAAAATTTATATAAAGCGTTTGTGAGCAGAGCCTCTAACGGAAAAAATAATAACTGTCAAATTATTGA
AGAGATCCTATCTCTTAGGACTAAACAGGCTAATCTTCTTGGTTATGAAAGTTGGGCAGAACTAAGTCTCTCAACAAAAA
TGGCTAATAAAATAAAAAATGTCGAGAAACTTTTAGAGGAATTGAGAAAACCTGCTTTTAAAACAGCCAAAAATGAATTA
GAAAAACTCAATAAGTTTTCAAAAGAAAATGGATTTCCACCTTTCGAAGCTCTTGAAGCTTGGGACATTAGTTATTGGTC
TGAAATCCTTAGAAAGGAGGAGCTTAATTTAGATCAAGAATCACTTAGACCATGGTTCCCTCTTAATGATGTTTTAAAAG
GTCTATTTAATCTTAGTGAAAACCTATTCGAAATCAAAGTAGTTGAAGCGACTAATGAAGCGCCGGTATGGAATGATGAC
GTTTTGTATTTTAATATTCTAAATAAGGATGATAATAAAATAGCTTCCTTTTATCTTGACCCCTACTCACGACCCGAGTC
AAAGCGAGGAGGTGCATGGATGGATGAATGTCTTAACAAAAATAATCATGGTAGAAATATTTTGCCTGTTGCCTATTTAG
TTTGTAATCAAACTCCACCATCCAAAGACAAGCCCAGTTTGATGAGTTTTGATGAAGTTCAAACTCTTTTCCATGAATTT
GGTCATGGACTTCAACATATGCTTACCACCGTAAATCTTCCACAAGCAGCTGGTATTAATAATGTTGAATGGGATGCTGT
TGAACTTCCTAGTCAATTTATGGAAAACTGGTGTTTTCACAAAAAAACCTTGTTAAATATTGCAAAGCATTATGAAACAG
GGGAAAGACTATCTGATGAGAATTTTGAAAAATTAGTAAAAAACAGAACTTTTAATTGTGGGATGGCTACTCTAAGACAA
TTACATTTTGCAATAACAGATCTAAGAATACATAGCAATATCAAAAGCAATAAGGATAAAAATTCAGAAGAGATCAGAAA
AGAAATTGCACGAGATACAACAGTAATCAACCCGATACAAGAAGATAAATTCCTTTGCTGCTTTAGTCACATATTTGCAG
GAGGTTATTCAGCTGGATATTATTCTTACAAATGGGCAGAAGTTTTAAGTGCCGATGCTTTTTCTATGTTTGAAGAGGCA
GATTTAGAAAATAATCAAAATATAAAGAAAATTGGCAAAAAGTTTAAAGACACAGTTTTAAGTCTTGGAGGAAGTTTCTC
TCCACTAGAAGTATTTAAATTATTTAGAGGGAGAGAACCAAAAACAGATTCTTTGATAAGACACTTAGGTCTATCATCTG
TTACCCAAGAAGCCTGTCAATAA

Upstream 100 bases:

>100_bases
ATTTATATGAATCTTCCACAGATGCTCTCAGTCAACAACTGACTTTAGCTAAATTAGTTGGGTTAATTTCAAACATCACT
TAATTTTAATATTCAAAAAA

Downstream 100 bases:

>100_bases
TTTGTGCGACCGCATCTTTATTCCTCACTAAATTTCTATGTTTATAAATTTTTAGTGATATTTTGTCACCGTAATTTAAA
TTTGCTCTCCATCCTGGGAA

Product: M3 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 700; Mature: 700

Protein sequence:

>700_residues
METSIFNYGELPEFKKFTSDRINKEFPSVIDKINLEFKNIENFLSNYLNQKNLDWDKVINPLNEVNEILRWSWGVISHLN
GVKNSESLREIYSKFLPEIINLSNKFGQSKIIYKALVKLKETNNFDKVKSRILDKEILEMEHRGISLNIDDQKEFNVISE
KLGKLSTNFSNNVLDATNAWFLILNDKSQIEGLPERVLELMSISAHEYLKKEGEADPKNGPWKLSLDIPTYTAFMTYAKD
RNLRENLYKAFVSRASNGKNNNCQIIEEILSLRTKQANLLGYESWAELSLSTKMANKIKNVEKLLEELRKPAFKTAKNEL
EKLNKFSKENGFPPFEALEAWDISYWSEILRKEELNLDQESLRPWFPLNDVLKGLFNLSENLFEIKVVEATNEAPVWNDD
VLYFNILNKDDNKIASFYLDPYSRPESKRGGAWMDECLNKNNHGRNILPVAYLVCNQTPPSKDKPSLMSFDEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKKTLLNIAKHYETGERLSDENFEKLVKNRTFNCGMATLRQ
LHFAITDLRIHSNIKSNKDKNSEEIRKEIARDTTVINPIQEDKFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENNQNIKKIGKKFKDTVLSLGGSFSPLEVFKLFRGREPKTDSLIRHLGLSSVTQEACQ

Sequences:

>Translated_700_residues
METSIFNYGELPEFKKFTSDRINKEFPSVIDKINLEFKNIENFLSNYLNQKNLDWDKVINPLNEVNEILRWSWGVISHLN
GVKNSESLREIYSKFLPEIINLSNKFGQSKIIYKALVKLKETNNFDKVKSRILDKEILEMEHRGISLNIDDQKEFNVISE
KLGKLSTNFSNNVLDATNAWFLILNDKSQIEGLPERVLELMSISAHEYLKKEGEADPKNGPWKLSLDIPTYTAFMTYAKD
RNLRENLYKAFVSRASNGKNNNCQIIEEILSLRTKQANLLGYESWAELSLSTKMANKIKNVEKLLEELRKPAFKTAKNEL
EKLNKFSKENGFPPFEALEAWDISYWSEILRKEELNLDQESLRPWFPLNDVLKGLFNLSENLFEIKVVEATNEAPVWNDD
VLYFNILNKDDNKIASFYLDPYSRPESKRGGAWMDECLNKNNHGRNILPVAYLVCNQTPPSKDKPSLMSFDEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKKTLLNIAKHYETGERLSDENFEKLVKNRTFNCGMATLRQ
LHFAITDLRIHSNIKSNKDKNSEEIRKEIARDTTVINPIQEDKFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENNQNIKKIGKKFKDTVLSLGGSFSPLEVFKLFRGREPKTDSLIRHLGLSSVTQEACQ
>Mature_700_residues
METSIFNYGELPEFKKFTSDRINKEFPSVIDKINLEFKNIENFLSNYLNQKNLDWDKVINPLNEVNEILRWSWGVISHLN
GVKNSESLREIYSKFLPEIINLSNKFGQSKIIYKALVKLKETNNFDKVKSRILDKEILEMEHRGISLNIDDQKEFNVISE
KLGKLSTNFSNNVLDATNAWFLILNDKSQIEGLPERVLELMSISAHEYLKKEGEADPKNGPWKLSLDIPTYTAFMTYAKD
RNLRENLYKAFVSRASNGKNNNCQIIEEILSLRTKQANLLGYESWAELSLSTKMANKIKNVEKLLEELRKPAFKTAKNEL
EKLNKFSKENGFPPFEALEAWDISYWSEILRKEELNLDQESLRPWFPLNDVLKGLFNLSENLFEIKVVEATNEAPVWNDD
VLYFNILNKDDNKIASFYLDPYSRPESKRGGAWMDECLNKNNHGRNILPVAYLVCNQTPPSKDKPSLMSFDEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKKTLLNIAKHYETGERLSDENFEKLVKNRTFNCGMATLRQ
LHFAITDLRIHSNIKSNKDKNSEEIRKEIARDTTVINPIQEDKFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENNQNIKKIGKKFKDTVLSLGGSFSPLEVFKLFRGREPKTDSLIRHLGLSSVTQEACQ

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=654, Percent_Identity=27.3700305810398, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI14149738, Length=594, Percent_Identity=29.7979797979798, Blast_Score=223, Evalue=6e-58,
Organism=Homo sapiens, GI156105687, Length=619, Percent_Identity=23.1017770597738, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1789913, Length=693, Percent_Identity=39.3939393939394, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1787819, Length=691, Percent_Identity=28.3646888567294, Blast_Score=252, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI71999758, Length=611, Percent_Identity=23.7315875613748, Blast_Score=135, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565901, Length=472, Percent_Identity=22.6694915254237, Blast_Score=96, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319793, Length=542, Percent_Identity=30.9963099630996, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6322715, Length=583, Percent_Identity=23.6706689536878, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI21356111, Length=700, Percent_Identity=30.1428571428571, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI20129717, Length=608, Percent_Identity=21.2171052631579, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 80893; Mature: 80893

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSIFNYGELPEFKKFTSDRINKEFPSVIDKINLEFKNIENFLSNYLNQKNLDWDKVIN
CCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
PLNEVNEILRWSWGVISHLNGVKNSESLREIYSKFLPEIINLSNKFGQSKIIYKALVKLK
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDKVKSRILDKEILEMEHRGISLNIDDQKEFNVISEKLGKLSTNFSNNVLDATNAW
HCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
FLILNDKSQIEGLPERVLELMSISAHEYLKKEGEADPKNGPWKLSLDIPTYTAFMTYAKD
EEEECCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHC
RNLRENLYKAFVSRASNGKNNNCQIIEEILSLRTKQANLLGYESWAELSLSTKMANKIKN
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VEKLLEELRKPAFKTAKNELEKLNKFSKENGFPPFEALEAWDISYWSEILRKEELNLDQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHCCCCHH
SLRPWFPLNDVLKGLFNLSENLFEIKVVEATNEAPVWNDDVLYFNILNKDDNKIASFYLD
HCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEC
PYSRPESKRGGAWMDECLNKNNHGRNILPVAYLVCNQTPPSKDKPSLMSFDEVQTLFHEF
CCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKKTLLNIAKHYETGERLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NFEKLVKNRTFNCGMATLRQLHFAITDLRIHSNIKSNKDKNSEEIRKEIARDTTVINPIQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHCCCCH
EDKFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENNQNIKKIGKKFKDTVL
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
SLGGSFSPLEVFKLFRGREPKTDSLIRHLGLSSVTQEACQ
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
METSIFNYGELPEFKKFTSDRINKEFPSVIDKINLEFKNIENFLSNYLNQKNLDWDKVIN
CCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHH
PLNEVNEILRWSWGVISHLNGVKNSESLREIYSKFLPEIINLSNKFGQSKIIYKALVKLK
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDKVKSRILDKEILEMEHRGISLNIDDQKEFNVISEKLGKLSTNFSNNVLDATNAW
HCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
FLILNDKSQIEGLPERVLELMSISAHEYLKKEGEADPKNGPWKLSLDIPTYTAFMTYAKD
EEEECCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHC
RNLRENLYKAFVSRASNGKNNNCQIIEEILSLRTKQANLLGYESWAELSLSTKMANKIKN
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VEKLLEELRKPAFKTAKNELEKLNKFSKENGFPPFEALEAWDISYWSEILRKEELNLDQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHCCCCHH
SLRPWFPLNDVLKGLFNLSENLFEIKVVEATNEAPVWNDDVLYFNILNKDDNKIASFYLD
HCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCEEEEEEC
PYSRPESKRGGAWMDECLNKNNHGRNILPVAYLVCNQTPPSKDKPSLMSFDEVQTLFHEF
CCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKKTLLNIAKHYETGERLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NFEKLVKNRTFNCGMATLRQLHFAITDLRIHSNIKSNKDKNSEEIRKEIARDTTVINPIQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHCCCCH
EDKFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENNQNIKKIGKKFKDTVL
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
SLGGSFSPLEVFKLFRGREPKTDSLIRHLGLSSVTQEACQ
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]