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The map label for this gene is hisG [H]

Identifier: 123965859

GI number: 123965859

Start: 557757

End: 558395

Strand: Direct

Name: hisG [H]

Synonym: P9515_06241

Alternate gene names: 123965859

Gene position: 557757-558395 (Clockwise)

Preceding gene: 123965855

Following gene: 123965860

Centisome position: 32.73

GC content: 35.37

Gene sequence:

>639_bases
ATGATTACTATAGCTTTACCCAAAGGAGCTCTGTTAGAGGATTCAATTTCAATTTTTAAAAAAGCAGGATTGAACTTCTC
TGATGCATTATTAGAGAATAATAGATCATTAACTATTGAATCAGAATGTAAACGAGCAAAGGCCTTATTGGTAAGAAATG
GAGACGTTCCCGTTTATGTAAGTTACGGACAAGCTGATTTAGGAATCGTAGGATATGACGTATTACAGGAGTCAGAATTA
AAAGTAGCTAAGTTACTTGATTTAGAGTTTGGTGGATGTCATATGTCTCTTGCAGTAAAAAATACTAGTAATTATTCAAA
ACCGACCGATCTTCCCGCTAATTGTAAAGTGGCAAGTAAATTTACAAAAACGGCAAGGGCCTATTTTGATGACTTAAATA
TACCCGTTGAGATTGTCCATTTAACTGGGTCAGTCGAGCTTGGTCCTATTACGGGGATGGCTGAAGCTATTGTTGATTTG
GTCGCAACAGGCAAGACTCTTAAAGAAAACGGTTTAAGTAAAATTGATGATCTTTTTTATTCAACTGCAAGGTTAATTGC
CAATCCTCTCTCTATTAGATTAGATAGCAATCCTCTCCGAGATGTGATTTTATCAATAGAATCTTTTAAAGGTACATAG

Upstream 100 bases:

>100_bases
ATATGACATTATCACTGAGAACTCTAATTCCAATTATTGTTTGCTCTTTATTAAATTCCATTATTACCTTAGAATTAAAA
GATTGCGTAAAAATTGATCT

Downstream 100 bases:

>100_bases
CATATTTAAATAAATGTTTTTGAATGATTTTAATAGAATCAAAAAATTAGGTAGATATTTAACTAAAGATAAGAAAACAA
TTTATCTTATTTTAATAGTC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MITIALPKGALLEDSISIFKKAGLNFSDALLENNRSLTIESECKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLQESEL
KVAKLLDLEFGGCHMSLAVKNTSNYSKPTDLPANCKVASKFTKTARAYFDDLNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLSKIDDLFYSTARLIANPLSIRLDSNPLRDVILSIESFKGT

Sequences:

>Translated_212_residues
MITIALPKGALLEDSISIFKKAGLNFSDALLENNRSLTIESECKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLQESEL
KVAKLLDLEFGGCHMSLAVKNTSNYSKPTDLPANCKVASKFTKTARAYFDDLNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLSKIDDLFYSTARLIANPLSIRLDSNPLRDVILSIESFKGT
>Mature_212_residues
MITIALPKGALLEDSISIFKKAGLNFSDALLENNRSLTIESECKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLQESEL
KVAKLLDLEFGGCHMSLAVKNTSNYSKPTDLPANCKVASKFTKTARAYFDDLNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLSKIDDLFYSTARLIANPLSIRLDSNPLRDVILSIESFKGT

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=195, Percent_Identity=33.8461538461538, Blast_Score=94, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=197, Percent_Identity=35.5329949238579, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 22923; Mature: 22923

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIALPKGALLEDSISIFKKAGLNFSDALLENNRSLTIESECKRAKALLVRNGDVPVYV
CEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEHHHHHHHHEEEEECCCEEEEE
SYGQADLGIVGYDVLQESELKVAKLLDLEFGGCHMSLAVKNTSNYSKPTDLPANCKVASK
ECCCCCCCEEEHHHHCCCCCCEEHHEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
FTKTARAYFDDLNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLSKIDDLFY
HHHHHHHHHHCCCCCEEEEEEECCEEECCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHH
STARLIANPLSIRLDSNPLRDVILSIESFKGT
HHHHHHCCCEEEEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITIALPKGALLEDSISIFKKAGLNFSDALLENNRSLTIESECKRAKALLVRNGDVPVYV
CEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEHHHHHHHHEEEEECCCEEEEE
SYGQADLGIVGYDVLQESELKVAKLLDLEFGGCHMSLAVKNTSNYSKPTDLPANCKVASK
ECCCCCCCEEEHHHHCCCCCCEEHHEECCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
FTKTARAYFDDLNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLSKIDDLFY
HHHHHHHHHHCCCCCEEEEEEECCEEECCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHH
STARLIANPLSIRLDSNPLRDVILSIESFKGT
HHHHHHCCCEEEEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]