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The map label for this gene is cobK [H]

Identifier: 123965802

GI number: 123965802

Start: 506503

End: 507297

Strand: Direct

Name: cobK [H]

Synonym: P9515_05671

Alternate gene names: 123965802

Gene position: 506503-507297 (Clockwise)

Preceding gene: 123965800

Following gene: 123965803

Centisome position: 29.72

GC content: 28.05

Gene sequence:

>795_bases
ATGCACAATTCAGAAAATTGCCACGAAAATGTGTGGATCCTTTCAGGAACTTCAGATGGACCAGCCATCGTTAACAAACT
TTTAAAACTGGATTATGTAGTATTTGTAAGTGTTGTCACCCATAAAGCGAGTATGTCTTACTCTGAAAATTCAAAGTTAC
ACATCATTACAGGAAAATTAAATGATTCGAGAGAAATTATAGATTTTATTGAAAAAAATAAAATTAATTATGTAATAGAT
GCAACTCACCCATTTGCCTTAATAATTTCTAAAAATTTAAATGAAGCATGCAAAAAAATCAAAAAGCCTCTTTTGGCTTT
TGAAAGGAAATCGGAAATAAAACATTCCAAAAACTTTAACTATATAAATGGTTTAAAAGATATAAAGCGGCAAGGTCTAG
TAAATAAAAATATTCTGTTAGCAATAGGATCTAGATTACTAAATGATACTGCAAGTTATTATTTAGAATGCGGTGCAAAT
GTATTTACAAGAGTAATTCCAACATATGAGAGTATATCTAAAGCTTTTGCCTCATGTATTAAAAATTCAAACATAGCAAT
ACTTGAACCTAGTAAAAAAAAAGGAAATATTTTAGAAAAAAAACTTTGTGATCATTGGGACATAGATTATATACTTTGTA
GAGATTCTGGAAGTTATGCACAAATGAATTGGGAGGCAATTGTTTATGGAAGTGATATCAATTTATTTTTAGTTAAAAGG
CCAAAACTAAAATTTAAAAATCCGCTACTGTTTTTTGATTATGATGAGTTGATAAACCAAATAACTAAAAATTAA

Upstream 100 bases:

>100_bases
GTTTTATTATCTTTGGTGTATCTCATCTGAGGAGAGCTATTTATTACAGCTTGAATTAAACAATGATTCATGAACTTTCT
ATTTAATTAAAGACATCTTG

Downstream 100 bases:

>100_bases
TACTTTAGGATGAAGCCAGTCTTACTCGTGATATCAACTGAACTAAATAAAAAATCAGCTAAAAAAATTGCTAAGTTATT
AATCAAAAAAAAACTTGCAG

Product: precorrin-6X reductase

Products: Precorrin 6A; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MHNSENCHENVWILSGTSDGPAIVNKLLKLDYVVFVSVVTHKASMSYSENSKLHIITGKLNDSREIIDFIEKNKINYVID
ATHPFALIISKNLNEACKKIKKPLLAFERKSEIKHSKNFNYINGLKDIKRQGLVNKNILLAIGSRLLNDTASYYLECGAN
VFTRVIPTYESISKAFASCIKNSNIAILEPSKKKGNILEKKLCDHWDIDYILCRDSGSYAQMNWEAIVYGSDINLFLVKR
PKLKFKNPLLFFDYDELINQITKN

Sequences:

>Translated_264_residues
MHNSENCHENVWILSGTSDGPAIVNKLLKLDYVVFVSVVTHKASMSYSENSKLHIITGKLNDSREIIDFIEKNKINYVID
ATHPFALIISKNLNEACKKIKKPLLAFERKSEIKHSKNFNYINGLKDIKRQGLVNKNILLAIGSRLLNDTASYYLECGAN
VFTRVIPTYESISKAFASCIKNSNIAILEPSKKKGNILEKKLCDHWDIDYILCRDSGSYAQMNWEAIVYGSDINLFLVKR
PKLKFKNPLLFFDYDELINQITKN
>Mature_264_residues
MHNSENCHENVWILSGTSDGPAIVNKLLKLDYVVFVSVVTHKASMSYSENSKLHIITGKLNDSREIIDFIEKNKINYVID
ATHPFALIISKNLNEACKKIKKPLLAFERKSEIKHSKNFNYINGLKDIKRQGLVNKNILLAIGSRLLNDTASYYLECGAN
VFTRVIPTYESISKAFASCIKNSNIAILEPSKKKGNILEKKLCDHWDIDYILCRDSGSYAQMNWEAIVYGSDINLFLVKR
PKLKFKNPLLFFDYDELINQITKN

Specific function: Catalyzes the reduction of the macrocycle of cobalt- precorrin-6X into cobalt-precorrin-6Y [H]

COG id: COG2099

COG function: function code H; Precorrin-6x reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin-6x reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003723 [H]

Pfam domain/function: PF02571 CbiJ [H]

EC number: 1.3.1.54

Molecular weight: Translated: 30153; Mature: 30153

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS51014 COBK_CBIJ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNSENCHENVWILSGTSDGPAIVNKLLKLDYVVFVSVVTHKASMSYSENSKLHIITGKL
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
NDSREIIDFIEKNKINYVIDATHPFALIISKNLNEACKKIKKPLLAFERKSEIKHSKNFN
CCHHHHHHHHHCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YINGLKDIKRQGLVNKNILLAIGSRLLNDTASYYLECGANVFTRVIPTYESISKAFASCI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHH
KNSNIAILEPSKKKGNILEKKLCDHWDIDYILCRDSGSYAQMNWEAIVYGSDINLFLVKR
CCCCEEEECCCCCCCCHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEEEECCCEEEEEEC
PKLKFKNPLLFFDYDELINQITKN
CCCCCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MHNSENCHENVWILSGTSDGPAIVNKLLKLDYVVFVSVVTHKASMSYSENSKLHIITGKL
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
NDSREIIDFIEKNKINYVIDATHPFALIISKNLNEACKKIKKPLLAFERKSEIKHSKNFN
CCHHHHHHHHHCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YINGLKDIKRQGLVNKNILLAIGSRLLNDTASYYLECGANVFTRVIPTYESISKAFASCI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHH
KNSNIAILEPSKKKGNILEKKLCDHWDIDYILCRDSGSYAQMNWEAIVYGSDINLFLVKR
CCCCEEEECCCCCCCCHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEEEECCCEEEEEEC
PKLKFKNPLLFFDYDELINQITKN
CCCCCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 6B; NADP+

Specific reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]