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The map label for this gene is groEL

Identifier: 123965749

GI number: 123965749

Start: 460973

End: 462736

Strand: Reverse

Name: groEL

Synonym: P9515_05141

Alternate gene names: 123965749

Gene position: 462736-460973 (Counterclockwise)

Preceding gene: 123965751

Following gene: 123965743

Centisome position: 27.15

GC content: 38.04

Gene sequence:

>1764_bases
ATGCCAAAACAACTGAGCTTTTCGAACGACTCACGAGAAGCGCTCGAAAACGGAGTTAATACTGTAGCTAATGCTGTTAA
GGTAACTATTGGACCCAAAGCAAAGAATGTTGTAATAGAGAGAAAATTTGGTTCACCAGACATAGTGAGAGATGGATCTA
CTGTTGCTAAAGAAATCAACCTTGACAACCCAATCTCTAATTTAGGGGCAAAATTAATTGAACAAGTAGCCTCAAAAACT
AAAGAGAGTGCTGGGGATGGAACAACAACAGCAACAATCTTGACTCAAATAATGGTTCAAGAAGGTTTAAAAAATATAGC
AGCTGGAGCTAGTCCAATCGAGCTCAAAAAAGGAATGGAGAAAGGATTAGATATTGTTTTAGAGAAATTAAAATCAAAGA
GTATCAAAATAAACGGTTCAGATATTCAAAAAGTTGCGACAGTAAGTGCAGGAGGAGATGAAGAGATAGGTTCAATAATT
TCAAAAGCAATGGATATTGTAACTTCAGATGGGGTTATAACTGTTGAAGAATCCCAATCACTAGAGACGGAATTAGATAT
CACAGAGGGAATGTCTTTTGATAGAGGTTATAGTTCGCCCTATTTTGTAACAGATCAAGAAAGACAGATTTGTGAACTTG
AAAATCCTAAGATCTTAATCACAGACCAAAAGATTTCAACGTTAACAAACCTAGTTCCTATTCTCGAAGAAATTCAAAAA
TCCTCTTCTCCTTTTTTAGTTTTAGCTGAAGACATTGAAGGAGAGGCATTAACGACCCTTGTTTTAAATAAAAATAGTGG
GGTATTAAATGTTTCAGCTGTTCGAGCTCCATCATTTGGCGAAAGAAGAAAGGCTGCTTTAGAAGATATTGCGATTCTTA
CTGGGGCTAGATTAATTAGCGAAGATCAATCAATGAAATTAGAAGAGGTTACCATCAATGATCTTGGGAAAGCAAAGAAA
ATAACGATCTCAAAGGATAAAACAACCATCGTGGCTTTTGACGATACCAAAGATTTAGTAAAAGCAAGAGTTGAAAAATT
AAAAAGGGAAGTAGAAATAACTGAATCAGAATACGACAAGGATAAAATTAATGAGAGAATAGCAAAACTTGCTGGTGGGG
TAGCTCTAATTAAAGTTGGTGCGGCGACGGAAACAGAGATGAAGTATAAAAAATTAAGAATAGAAGATTCACTTAATGCA
ACAAAAGCTGCCATAGAAGAAGGAGTTGTTTCAGGGGGAGGGCAAACTTTAATAGAGATTTCAGAAGAACTCTCTAATTT
AGGCAAAGAAAAATCAGTTGATTTAAATACAGGTATTAAAATTATTACAAAAGCACTTTTAGAACCTACCAAACAAATAG
CAAGAAATGCTGGTTTTAATGGGGATGTAGTTATTGCGGATATTAAAAGACTTAATAAAGGCTTTAATGCTAATAATGGA
CAATATGAAAATTTAAATCAATCAGGAATATTAGACCCAACTAAAGTTATTCGATTAGCTCTTCAAGATTCAGTATCAAT
CGCAGCAATGATTCTTACAACAGAAGTTGCAGTAGCTGACATCCCAGAACCAGAGGCACCTGCACCTGGAGGACCCGGAG
CAGATCCGATGGGTGGAATGGGAGGCATGGGCGGCATGGGAGGCATGGGTATGCCTGGCATGGGAGGCATGGGTATGCCT
GGTATGGGCGGCATGGGTATGCCTGGCATGGGCGGCATGGGTATGCCTGGCATGGGAGGCATGGGTATGCCTGGTATGAT
GTAG

Upstream 100 bases:

>100_bases
ATAGCTGTTTAAGAGAAATTCGGCTTTCCCCACTTAATTAAGTATCCCTTAAATTTAATTTCATGGGAGATTATAATAAG
AACTTAAAGATTTCAATAAA

Downstream 100 bases:

>100_bases
GCTAGCTGGCTTTTTTACCGTTGTTAATCCATTTTCTGAGATTATTTATTTTAGGCAGCGGTAATTCCTTTAATTTGTTA
TCTTCACTCTTGTTTTTATA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MPKQLSFSNDSREALENGVNTVANAVKVTIGPKAKNVVIERKFGSPDIVRDGSTVAKEINLDNPISNLGAKLIEQVASKT
KESAGDGTTTATILTQIMVQEGLKNIAAGASPIELKKGMEKGLDIVLEKLKSKSIKINGSDIQKVATVSAGGDEEIGSII
SKAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQICELENPKILITDQKISTLTNLVPILEEIQK
SSSPFLVLAEDIEGEALTTLVLNKNSGVLNVSAVRAPSFGERRKAALEDIAILTGARLISEDQSMKLEEVTINDLGKAKK
ITISKDKTTIVAFDDTKDLVKARVEKLKREVEITESEYDKDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNA
TKAAIEEGVVSGGGQTLIEISEELSNLGKEKSVDLNTGIKIITKALLEPTKQIARNAGFNGDVVIADIKRLNKGFNANNG
QYENLNQSGILDPTKVIRLALQDSVSIAAMILTTEVAVADIPEPEAPAPGGPGADPMGGMGGMGGMGGMGMPGMGGMGMP
GMGGMGMPGMGGMGMPGMGGMGMPGMM

Sequences:

>Translated_587_residues
MPKQLSFSNDSREALENGVNTVANAVKVTIGPKAKNVVIERKFGSPDIVRDGSTVAKEINLDNPISNLGAKLIEQVASKT
KESAGDGTTTATILTQIMVQEGLKNIAAGASPIELKKGMEKGLDIVLEKLKSKSIKINGSDIQKVATVSAGGDEEIGSII
SKAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQICELENPKILITDQKISTLTNLVPILEEIQK
SSSPFLVLAEDIEGEALTTLVLNKNSGVLNVSAVRAPSFGERRKAALEDIAILTGARLISEDQSMKLEEVTINDLGKAKK
ITISKDKTTIVAFDDTKDLVKARVEKLKREVEITESEYDKDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNA
TKAAIEEGVVSGGGQTLIEISEELSNLGKEKSVDLNTGIKIITKALLEPTKQIARNAGFNGDVVIADIKRLNKGFNANNG
QYENLNQSGILDPTKVIRLALQDSVSIAAMILTTEVAVADIPEPEAPAPGGPGADPMGGMGGMGGMGGMGMPGMGGMGMP
GMGGMGMPGMGGMGMPGMGGMGMPGMM
>Mature_586_residues
PKQLSFSNDSREALENGVNTVANAVKVTIGPKAKNVVIERKFGSPDIVRDGSTVAKEINLDNPISNLGAKLIEQVASKTK
ESAGDGTTTATILTQIMVQEGLKNIAAGASPIELKKGMEKGLDIVLEKLKSKSIKINGSDIQKVATVSAGGDEEIGSIIS
KAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQICELENPKILITDQKISTLTNLVPILEEIQKS
SSPFLVLAEDIEGEALTTLVLNKNSGVLNVSAVRAPSFGERRKAALEDIAILTGARLISEDQSMKLEEVTINDLGKAKKI
TISKDKTTIVAFDDTKDLVKARVEKLKREVEITESEYDKDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNAT
KAAIEEGVVSGGGQTLIEISEELSNLGKEKSVDLNTGIKIITKALLEPTKQIARNAGFNGDVVIADIKRLNKGFNANNGQ
YENLNQSGILDPTKVIRLALQDSVSIAAMILTTEVAVADIPEPEAPAPGGPGADPMGGMGGMGGMGGMGMPGMGGMGMPG
MGGMGMPGMGGMGMPGMGGMGMPGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=42.8842504743833, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=42.8842504743833, Blast_Score=428, Evalue=1e-120,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=48.9563567362429, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=42.9378531073446, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI193210679, Length=226, Percent_Identity=39.8230088495575, Blast_Score=161, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=43.8095238095238, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=42.6944971537002, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=42.6944971537002, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=41.7457305502846, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=41.7457305502846, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=41.7457305502846, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=41.254752851711, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=33.5849056603774, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=33.5849056603774, Blast_Score=260, Evalue=2e-69,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_PROM5 (A2BVB2)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001010830.1
- ProteinModelPortal:   A2BVB2
- SMR:   A2BVB2
- STRING:   A2BVB2
- GeneID:   4720027
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_05141
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   GASPIEL
- ProtClustDB:   PRK12849
- BioCyc:   PMAR167542:P9515ORF_0549-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 61973; Mature: 61842

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKQLSFSNDSREALENGVNTVANAVKVTIGPKAKNVVIERKFGSPDIVRDGSTVAKEIN
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCEECCCHHHHHCC
LDNPISNLGAKLIEQVASKTKESAGDGTTTATILTQIMVQEGLKNIAAGASPIELKKGME
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KGLDIVLEKLKSKSIKINGSDIQKVATVSAGGDEEIGSIISKAMDIVTSDGVITVEESQS
HHHHHHHHHHCCCCEEECCCHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
LETELDITEGMSFDRGYSSPYFVTDQERQICELENPKILITDQKISTLTNLVPILEEIQK
CCCCCCHHHCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
SSSPFLVLAEDIEGEALTTLVLNKNSGVLNVSAVRAPSFGERRKAALEDIAILTGARLIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
EDQSMKLEEVTINDLGKAKKITISKDKTTIVAFDDTKDLVKARVEKLKREVEITESEYDK
CCCCCEEEEEEHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCH
DKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCHHHHHH
SEELSNLGKEKSVDLNTGIKIITKALLEPTKQIARNAGFNGDVVIADIKRLNKGFNANNG
HHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCC
QYENLNQSGILDPTKVIRLALQDSVSIAAMILTTEVAVADIPEPEAPAPGGPGADPMGGM
CCCCCCCCCCCCHHHHHHHHHHCCHHHEEHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
GGMGGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKQLSFSNDSREALENGVNTVANAVKVTIGPKAKNVVIERKFGSPDIVRDGSTVAKEIN
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCEECCCHHHHHCC
LDNPISNLGAKLIEQVASKTKESAGDGTTTATILTQIMVQEGLKNIAAGASPIELKKGME
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KGLDIVLEKLKSKSIKINGSDIQKVATVSAGGDEEIGSIISKAMDIVTSDGVITVEESQS
HHHHHHHHHHCCCCEEECCCHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
LETELDITEGMSFDRGYSSPYFVTDQERQICELENPKILITDQKISTLTNLVPILEEIQK
CCCCCCHHHCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
SSSPFLVLAEDIEGEALTTLVLNKNSGVLNVSAVRAPSFGERRKAALEDIAILTGARLIS
CCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
EDQSMKLEEVTINDLGKAKKITISKDKTTIVAFDDTKDLVKARVEKLKREVEITESEYDK
CCCCCEEEEEEHHHCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHCCH
DKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEI
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCHHHHHH
SEELSNLGKEKSVDLNTGIKIITKALLEPTKQIARNAGFNGDVVIADIKRLNKGFNANNG
HHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCC
QYENLNQSGILDPTKVIRLALQDSVSIAAMILTTEVAVADIPEPEAPAPGGPGADPMGGM
CCCCCCCCCCCCHHHHHHHHHHCCHHHEEHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
GGMGGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA