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The map label for this gene is cyoE

Identifier: 123965745

GI number: 123965745

Start: 457629

End: 458627

Strand: Direct

Name: cyoE

Synonym: P9515_05101

Alternate gene names: 123965745

Gene position: 457629-458627 (Clockwise)

Preceding gene: 123965744

Following gene: 123965746

Centisome position: 26.85

GC content: 36.64

Gene sequence:

>999_bases
ATGAAAAGTAATTTAGAAAACTTTAATTTTCAGACTTCAATTCGTGAACAAGTTGTACCCTCAAGAAAAAAAGTAATACT
TCCTGCTTGGCTTGAAGTTGCCAAACCAAGATTGATTCCATTATTACTAGCTACAACTTTAGGTGGTATGGCATTGACGG
AAGAATGGCCTTTATCCTCTCCTAAACTTATCTGTACTTTAGGAGGCGGTGCCTTGGCAGCTGCGGCAGCTGGAGCTCTT
AACTGCTTATGGGAAATGGACCTAGATAAGAGGATGAAAAGGACAAGTAATAGAGCTTTACCTTCAGGTAAATTATCATT
TAATACTGTATTTTTAGGGGCCGTATCTTGTACATTTGCAGCTGCAATGCTTTTGATAAGTGGAGTAAATTATTTAGCTG
CCGGATTAACATTGCTGGGATTATGTAGTTATGTGATTTTGTATACGATAATTCTTAAACCAAGAACAACTCAAAATATT
GTTTTTGGTGGAGTTGCAGGGGCCATACCTCCTTTAGTAGGAGCTTCAGCAGCTACAGGACATGTAGGTCTTAGTGGTTG
GTGGCTATTTGGGTTGGTAATGCTTTGGACGCCAGCACATTTTTGGGCTCTTGCAATTTTATTAAAAGATGATTATGCGT
CTGTCGGAATACCCATGCTTCCTTCCGTTAAAGGTTCAGCTTTTACAGTCAAAGCTATTTCACGTTATGGATGGGCAACA
GTATTCATGAGTATTCTAGGTGTCTTTGCTTTACCTGAAGGAGGACTGCTTTATGTGATAATGCTTTTACCTTTTAATGG
AAGACTTTTACAATTAATCAATAGATTGAAAAGTTCACCTGATGATTTAGAAAAAGCTAAAGGATTATTTAGATGGTCAA
TACTTTATATGTTTGGTATTTGTCTTTTACTTTTAATTTCAAGAACCCAACTTTCTGTTGATTTTGAGCAGCAGTCTATG
CAAATATTCTTATCTTTGAAGGCATACTTTAATATTTAG

Upstream 100 bases:

>100_bases
CATTATTAATTGCGATCCTAACAGCATTGATTTTTAGAAATCCTAAGTTAAATAAAAAAATCAATCAATCATTTAATCCA
GTAATAGTATCTTTAAACTC

Downstream 100 bases:

>100_bases
ATTGATGTAAAATGTTGATAGAAAAAATTCTGGTTTGATGAATTATATACAAATTACGGATCTTTCAAAATCATATTCTG
ATATTGAGGCATTAAAAAAA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKSNLENFNFQTSIREQVVPSRKKVILPAWLEVAKPRLIPLLLATTLGGMALTEEWPLSSPKLICTLGGGALAAAAAGAL
NCLWEMDLDKRMKRTSNRALPSGKLSFNTVFLGAVSCTFAAAMLLISGVNYLAAGLTLLGLCSYVILYTIILKPRTTQNI
VFGGVAGAIPPLVGASAATGHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSAFTVKAISRYGWAT
VFMSILGVFALPEGGLLYVIMLLPFNGRLLQLINRLKSSPDDLEKAKGLFRWSILYMFGICLLLLISRTQLSVDFEQQSM
QIFLSLKAYFNI

Sequences:

>Translated_332_residues
MKSNLENFNFQTSIREQVVPSRKKVILPAWLEVAKPRLIPLLLATTLGGMALTEEWPLSSPKLICTLGGGALAAAAAGAL
NCLWEMDLDKRMKRTSNRALPSGKLSFNTVFLGAVSCTFAAAMLLISGVNYLAAGLTLLGLCSYVILYTIILKPRTTQNI
VFGGVAGAIPPLVGASAATGHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSAFTVKAISRYGWAT
VFMSILGVFALPEGGLLYVIMLLPFNGRLLQLINRLKSSPDDLEKAKGLFRWSILYMFGICLLLLISRTQLSVDFEQQSM
QIFLSLKAYFNI
>Mature_332_residues
MKSNLENFNFQTSIREQVVPSRKKVILPAWLEVAKPRLIPLLLATTLGGMALTEEWPLSSPKLICTLGGGALAAAAAGAL
NCLWEMDLDKRMKRTSNRALPSGKLSFNTVFLGAVSCTFAAAMLLISGVNYLAAGLTLLGLCSYVILYTIILKPRTTQNI
VFGGVAGAIPPLVGASAATGHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSAFTVKAISRYGWAT
VFMSILGVFALPEGGLLYVIMLLPFNGRLLQLINRLKSSPDDLEKAKGLFRWSILYMFGICLLLLISRTQLSVDFEQQSM
QIFLSLKAYFNI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=189, Percent_Identity=34.9206349206349, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786631, Length=290, Percent_Identity=30.3448275862069, Blast_Score=111, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71998235, Length=264, Percent_Identity=28.7878787878788, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325085, Length=198, Percent_Identity=30.8080808080808, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921064, Length=285, Percent_Identity=30.8771929824561, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_PROM5 (A2BVA8)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001010826.1
- STRING:   A2BVA8
- GeneID:   4720023
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_05101
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- ProtClustDB:   PRK04375
- BioCyc:   PMAR167542:P9515ORF_0545-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 36110; Mature: 36110

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1854d1f4)-; HASH(0x191b6a28)-; HASH(0x191b41d8)-; HASH(0x191b3fec)-; HASH(0x191b6cbc)-; HASH(0x191df208)-; HASH(0x191df46c)-;

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNLENFNFQTSIREQVVPSRKKVILPAWLEVAKPRLIPLLLATTLGGMALTEEWPLSS
CCCCCCCCCCHHHHHHHHCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCCEECCCCCCCC
PKLICTLGGGALAAAAAGALNCLWEMDLDKRMKRTSNRALPSGKLSFNTVFLGAVSCTFA
CCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
AAMLLISGVNYLAAGLTLLGLCSYVILYTIILKPRTTQNIVFGGVAGAIPPLVGASAATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHCCHHHCCCCCCC
HVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSAFTVKAISRYGWAT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHHH
VFMSILGVFALPEGGLLYVIMLLPFNGRLLQLINRLKSSPDDLEKAKGLFRWSILYMFGI
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
CLLLLISRTQLSVDFEQQSMQIFLSLKAYFNI
HHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MKSNLENFNFQTSIREQVVPSRKKVILPAWLEVAKPRLIPLLLATTLGGMALTEEWPLSS
CCCCCCCCCCHHHHHHHHCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCCEECCCCCCCC
PKLICTLGGGALAAAAAGALNCLWEMDLDKRMKRTSNRALPSGKLSFNTVFLGAVSCTFA
CCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHH
AAMLLISGVNYLAAGLTLLGLCSYVILYTIILKPRTTQNIVFGGVAGAIPPLVGASAATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHCCHHHCCCCCCC
HVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSAFTVKAISRYGWAT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHHH
VFMSILGVFALPEGGLLYVIMLLPFNGRLLQLINRLKSSPDDLEKAKGLFRWSILYMFGI
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
CLLLLISRTQLSVDFEQQSMQIFLSLKAYFNI
HHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA