| Definition | Prochlorococcus marinus str. MIT 9515, complete genome. |
|---|---|
| Accession | NC_008817 |
| Length | 1,704,176 |
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The map label for this gene is dfp [H]
Identifier: 123965496
GI number: 123965496
Start: 243240
End: 244496
Strand: Reverse
Name: dfp [H]
Synonym: P9515_02611
Alternate gene names: 123965496
Gene position: 244496-243240 (Counterclockwise)
Preceding gene: 123965497
Following gene: 123965495
Centisome position: 14.35
GC content: 30.23
Gene sequence:
>1257_bases ATGAAGAATAACTCTAAAGAATCAAAAATTAAGCTTCTCATATTAATTACTGGAAGTATTGCTGCAGTAAGAATCCCATT GCTTGTCAGCCAATTAGTGAAGGATAATTATGATGTTAAGTGTGTTATGTCTAAAAATGCGGAAAAATTAATACAGCCAG CTTCACTCTCTATTTTAAGTAGGAATGTTTGCGTATTAGATAAGGACCAATGGTCATATATTCAACCCAAACCTTTACAT ATAGATTTATGCAATTGGGCTGATTTTTTAATAATTGCTCCTTTGACGGCTACAACTCTCTCTAAATGGGTTACGGGTAA TGCAGATGGATTAATCTCCAGTATTTTAATCGCAAACAATAAGCCTATTATTGTTGCTCCTGCGATGAATTCTAATATGT GGATTAACCAAGCTGTTCAAAAAAATTATCAATGTCTTCTAAATTATTCTAATGTTTTGACCCTTGAACCAAGTAAAGGA ATCCTAGCTTGCGATGAAATTGGAATTGGTAAGATACCTCCTAATGATCTAATACAATTAGCTCTAACTTTTATACTTTC ACATAATAAAAAGACCTATTACAGAGATTTATCAAATAAAAAAATCTTAATTACAGGTGGATGTACATCAGAAAAAATTG ACGCAGCCAGAAAGATTACAAACAATAGTTCGGGAACAATGGGATTAATGCTTGCTCAAGTAGCTAGATTTAGAGGTGCA AATGTCAAATATATACATGGTCCTTTAAAAAATAGACTGGATATCACTGAAGGGATAGAAAGTGTCGAAATAGAAAATAG TACTGATTTAATTCAAGAAATTGAAAAAGAGATTTCGAAGTGCGATTATTTTATTATGAACGCAGCAGTTGCAGATTTCA AAATTTCAAGCGATACCTTAAAAAAAATCCCAAAAAGTAAATTTAGCAATTTTTTCAAAAATAGTATTGAATTTATACCT GACATATTAAGAGATTTCAGTAAAGTGAAAAAAGAAAATCAAATTTTTGTTGGTTTTTGTGCATTTACAGGCTCTATTCA AAATGCAAGAAAAACAATAAAAGAAAAAATAGTGCTTAAGGGATGTGATTTAATATTTGCAAATCCTATAGATATTGAAG AGCAAGGATTTGGTCCATTAGCTAAAAATGAAGGTTGGCTTTTTGATACAAAAAATATGGAACATCATATAGAAAAAACT TCTAAACTAGAACTAGCTAATAAGTTGATAAATCGAATTATTTCAGCGAATAAATAA
Upstream 100 bases:
>100_bases TTTGATGAATCAAAAACTCTGGATTTACTTTGGCCCTTAGCAATTAATAAGACCGAATTACCTTCTGATTATTCTTATTT ACTATGTTAGTAATAAGTTG
Downstream 100 bases:
>100_bases TTTATAAAAATTATATTTGTGTTTTTTTGTAATCTTAAGCTTTAAAAATAATCTTATATCTTAAAATAACTCAAGTTTTT AAAATAATTAAAAAAGCTAC
Product: putative p-pantothenate cysteine ligase and p-pantothenenoylcysteine decarboxylase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 418; Mature: 418
Protein sequence:
>418_residues MKNNSKESKIKLLILITGSIAAVRIPLLVSQLVKDNYDVKCVMSKNAEKLIQPASLSILSRNVCVLDKDQWSYIQPKPLH IDLCNWADFLIIAPLTATTLSKWVTGNADGLISSILIANNKPIIVAPAMNSNMWINQAVQKNYQCLLNYSNVLTLEPSKG ILACDEIGIGKIPPNDLIQLALTFILSHNKKTYYRDLSNKKILITGGCTSEKIDAARKITNNSSGTMGLMLAQVARFRGA NVKYIHGPLKNRLDITEGIESVEIENSTDLIQEIEKEISKCDYFIMNAAVADFKISSDTLKKIPKSKFSNFFKNSIEFIP DILRDFSKVKKENQIFVGFCAFTGSIQNARKTIKEKIVLKGCDLIFANPIDIEEQGFGPLAKNEGWLFDTKNMEHHIEKT SKLELANKLINRIISANK
Sequences:
>Translated_418_residues MKNNSKESKIKLLILITGSIAAVRIPLLVSQLVKDNYDVKCVMSKNAEKLIQPASLSILSRNVCVLDKDQWSYIQPKPLH IDLCNWADFLIIAPLTATTLSKWVTGNADGLISSILIANNKPIIVAPAMNSNMWINQAVQKNYQCLLNYSNVLTLEPSKG ILACDEIGIGKIPPNDLIQLALTFILSHNKKTYYRDLSNKKILITGGCTSEKIDAARKITNNSSGTMGLMLAQVARFRGA NVKYIHGPLKNRLDITEGIESVEIENSTDLIQEIEKEISKCDYFIMNAAVADFKISSDTLKKIPKSKFSNFFKNSIEFIP DILRDFSKVKKENQIFVGFCAFTGSIQNARKTIKEKIVLKGCDLIFANPIDIEEQGFGPLAKNEGWLFDTKNMEHHIEKT SKLELANKLINRIISANK >Mature_418_residues MKNNSKESKIKLLILITGSIAAVRIPLLVSQLVKDNYDVKCVMSKNAEKLIQPASLSILSRNVCVLDKDQWSYIQPKPLH IDLCNWADFLIIAPLTATTLSKWVTGNADGLISSILIANNKPIIVAPAMNSNMWINQAVQKNYQCLLNYSNVLTLEPSKG ILACDEIGIGKIPPNDLIQLALTFILSHNKKTYYRDLSNKKILITGGCTSEKIDAARKITNNSSGTMGLMLAQVARFRGA NVKYIHGPLKNRLDITEGIESVEIENSTDLIQEIEKEISKCDYFIMNAAVADFKISSDTLKKIPKSKFSNFFKNSIEFIP DILRDFSKVKKENQIFVGFCAFTGSIQNARKTIKEKIVLKGCDLIFANPIDIEEQGFGPLAKNEGWLFDTKNMEHHIEKT SKLELANKLINRIISANK
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=172, Percent_Identity=32.5581395348837, Blast_Score=89, Evalue=1e-17, Organism=Escherichia coli, GI87082301, Length=373, Percent_Identity=31.6353887399464, Blast_Score=162, Evalue=6e-41, Organism=Caenorhabditis elegans, GI17560194, Length=178, Percent_Identity=34.2696629213483, Blast_Score=92, Evalue=3e-19, Organism=Saccharomyces cerevisiae, GI6322762, Length=181, Percent_Identity=29.2817679558011, Blast_Score=87, Evalue=3e-18, Organism=Saccharomyces cerevisiae, GI6322925, Length=111, Percent_Identity=36.9369369369369, Blast_Score=65, Evalue=2e-11, Organism=Drosophila melanogaster, GI24657262, Length=133, Percent_Identity=32.3308270676692, Blast_Score=69, Evalue=5e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 46695; Mature: 46695
Theoretical pI: Translated: 9.41; Mature: 9.41
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.2 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 4.1 %Cys+Met (Translated Protein) 2.2 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKNNSKESKIKLLILITGSIAAVRIPLLVSQLVKDNYDVKCVMSKNAEKLIQPASLSILS CCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHC RNVCVLDKDQWSYIQPKPLHIDLCNWADFLIIAPLTATTLSKWVTGNADGLISSILIANN CCEEEEECCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHEEECC KPIIVAPAMNSNMWINQAVQKNYQCLLNYSNVLTLEPSKGILACDEIGIGKIPPNDLIQL CCEEEEECCCCCCHHHHHHHCCHHEEEECCCEEEECCCCCEEEECCCCCCCCCHHHHHHH ALTFILSHNKKTYYRDLSNKKILITGGCTSEKIDAARKITNNSSGTMGLMLAQVARFRGA HHHHHHHCCCCCEEHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC NVKYIHGPLKNRLDITEGIESVEIENSTDLIQEIEKEISKCDYFIMNAAVADFKISSDTL CEEEEECCCCCCCCHHHCCCCEEECCHHHHHHHHHHHHHHCCCHHEEHHHHCEEECHHHH KKIPKSKFSNFFKNSIEFIPDILRDFSKVKKENQIFVGFCAFTGSIQNARKTIKEKIVLK HHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHC GCDLIFANPIDIEEQGFGPLAKNEGWLFDTKNMEHHIEKTSKLELANKLINRIISANK CCCEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure MKNNSKESKIKLLILITGSIAAVRIPLLVSQLVKDNYDVKCVMSKNAEKLIQPASLSILS CCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHC RNVCVLDKDQWSYIQPKPLHIDLCNWADFLIIAPLTATTLSKWVTGNADGLISSILIANN CCEEEEECCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHEEECC KPIIVAPAMNSNMWINQAVQKNYQCLLNYSNVLTLEPSKGILACDEIGIGKIPPNDLIQL CCEEEEECCCCCCHHHHHHHCCHHEEEECCCEEEECCCCCEEEECCCCCCCCCHHHHHHH ALTFILSHNKKTYYRDLSNKKILITGGCTSEKIDAARKITNNSSGTMGLMLAQVARFRGA HHHHHHHCCCCCEEHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC NVKYIHGPLKNRLDITEGIESVEIENSTDLIQEIEKEISKCDYFIMNAAVADFKISSDTL CEEEEECCCCCCCCHHHCCCCEEECCHHHHHHHHHHHHHHCCCHHEEHHHHCEEECHHHH KKIPKSKFSNFFKNSIEFIPDILRDFSKVKKENQIFVGFCAFTGSIQNARKTIKEKIVLK HHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHC GCDLIFANPIDIEEQGFGPLAKNEGWLFDTKNMEHHIEKTSKLELANKLINRIISANK CCCEEEECCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8905231 [H]