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The map label for this gene is cysK [H]

Identifier: 123965372

GI number: 123965372

Start: 130364

End: 131332

Strand: Reverse

Name: cysK [H]

Synonym: P9515_01371

Alternate gene names: 123965372

Gene position: 131332-130364 (Counterclockwise)

Preceding gene: 123965375

Following gene: 123965371

Centisome position: 7.71

GC content: 36.64

Gene sequence:

>969_bases
ATGGAAATCGCAAGCGATATCACCTCCTTAGTTGGTAACACACCTTTAGTTAAATTAGATCGTATTAAAGATTACTGTAA
GTGTCATACTGAAATTATAGCTAAACTTGAAAGTTTCAATCCATCAGCATCTGTTAAAGATCGCATAGCGTATTCTATGT
TAAATTCAGCCGAAGAAGATGGTTTAATACTTCCAGGAAAAACGACCTTAATTGAAGCAACAAGTGGGAATACTGGCATA
GCTTTAGCAATGGTTGCAGCAGCTAAAGGCTATAGATTGATACTAACCATGCCAGACACCATGAGTATTGAGAGAAGGGC
AATGCTTCGAGCTTATGGTGCAGAATTGCAACTTACTCCAGGCACAGAGGGAATGAGAGGGGCATTAGAATTAGCGAATG
AATTATCTTCAAGTATTCCAAATAGCTTTCAATTTAACCAGTTTGAAAATCTCGCGAATCCTGAGATTCATGAAAGAACA
ACAGCAAAAGAAATTTGGGATCAATCTAATCAAAATATTGATGGATTAGTATCTGGGGTTGGTACTGGAGGAACAATAAC
TGGGTGCGCTAGATTTTTAAAAAAAGTGAATCCAAATTGCAAAATTTACGCAGTTGAGCCTGCAAAAAGTGCAGTTATAT
CTGGAGAAAAGCCAAGTTCTCACTCGATCCAAGGAATAGGTGCAGGCTTCATTCCTAAAGTCCTCAATACCCAGTTAATA
GACGAAATAATCAAGATAGATGATGATGATGCATTTTATTATGGGAGATTATTAGCTCGACTTGAGGGTCTTTTATCAGG
AATTAGTAGTGGGGCTGCTTTAGCCGCAGCAATAAAAATTGGTAAAAGGAAAGAATTTATTAAAAAAAGATTAATAGTAA
TCCTTCCAAGTTTCGGTGAAAGATATTTATCAACAGCAATGTTTGAATCTAATACTGTCGTTCAGGCTAGACAAGACGGT
TATTTATAA

Upstream 100 bases:

>100_bases
GTTTTTAAATTAACTTCAATTAAAAAATTTTTTTTTAAAAGATCTATACATGCAATTATCATTAAGATAAACAAATTCAT
TTTTTGTAGACTTTTTCTCC

Downstream 100 bases:

>100_bases
AAAGAGGTATTTAGATATGATCAAAAATTTTTATGAAGAGTTAGGCTTAAAAAAAAATGCGACTAAAAGCGAAATAAAAT
CTTCTTATCGTCGCTTAGTA

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MEIASDITSLVGNTPLVKLDRIKDYCKCHTEIIAKLESFNPSASVKDRIAYSMLNSAEEDGLILPGKTTLIEATSGNTGI
ALAMVAAAKGYRLILTMPDTMSIERRAMLRAYGAELQLTPGTEGMRGALELANELSSSIPNSFQFNQFENLANPEIHERT
TAKEIWDQSNQNIDGLVSGVGTGGTITGCARFLKKVNPNCKIYAVEPAKSAVISGEKPSSHSIQGIGAGFIPKVLNTQLI
DEIIKIDDDDAFYYGRLLARLEGLLSGISSGAALAAAIKIGKRKEFIKKRLIVILPSFGERYLSTAMFESNTVVQARQDG
YL

Sequences:

>Translated_322_residues
MEIASDITSLVGNTPLVKLDRIKDYCKCHTEIIAKLESFNPSASVKDRIAYSMLNSAEEDGLILPGKTTLIEATSGNTGI
ALAMVAAAKGYRLILTMPDTMSIERRAMLRAYGAELQLTPGTEGMRGALELANELSSSIPNSFQFNQFENLANPEIHERT
TAKEIWDQSNQNIDGLVSGVGTGGTITGCARFLKKVNPNCKIYAVEPAKSAVISGEKPSSHSIQGIGAGFIPKVLNTQLI
DEIIKIDDDDAFYYGRLLARLEGLLSGISSGAALAAAIKIGKRKEFIKKRLIVILPSFGERYLSTAMFESNTVVQARQDG
YL
>Mature_322_residues
MEIASDITSLVGNTPLVKLDRIKDYCKCHTEIIAKLESFNPSASVKDRIAYSMLNSAEEDGLILPGKTTLIEATSGNTGI
ALAMVAAAKGYRLILTMPDTMSIERRAMLRAYGAELQLTPGTEGMRGALELANELSSSIPNSFQFNQFENLANPEIHERT
TAKEIWDQSNQNIDGLVSGVGTGGTITGCARFLKKVNPNCKIYAVEPAKSAVISGEKPSSHSIQGIGAGFIPKVLNTQLI
DEIIKIDDDDAFYYGRLLARLEGLLSGISSGAALAAAIKIGKRKEFIKKRLIVILPSFGERYLSTAMFESNTVVQARQDG
YL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=41.4790996784566, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=41.4790996784566, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=41.4790996784566, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=51.2658227848101, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=44.078947368421, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=50.6666666666667, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=49.3464052287582, Blast_Score=290, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=47.3856209150327, Blast_Score=282, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=48.1727574750831, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=45.4545454545455, Blast_Score=247, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=46.2264150943396, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=36.4779874213836, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=305, Percent_Identity=35.7377049180328, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=39.1666666666667, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=39.4904458598726, Blast_Score=212, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6321449, Length=337, Percent_Identity=33.2344213649852, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=40.1234567901235, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=40.1234567901235, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34824; Mature: 34824

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIASDITSLVGNTPLVKLDRIKDYCKCHTEIIAKLESFNPSASVKDRIAYSMLNSAEED
CCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
GLILPGKTTLIEATSGNTGIALAMVAAAKGYRLILTMPDTMSIERRAMLRAYGAELQLTP
CEEECCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GTEGMRGALELANELSSSIPNSFQFNQFENLANPEIHERTTAKEIWDQSNQNIDGLVSGV
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCC
GTGGTITGCARFLKKVNPNCKIYAVEPAKSAVISGEKPSSHSIQGIGAGFIPKVLNTQLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DEIIKIDDDDAFYYGRLLARLEGLLSGISSGAALAAAIKIGKRKEFIKKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCHHH
RYLSTAMFESNTVVQARQDGYL
HHHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure
MEIASDITSLVGNTPLVKLDRIKDYCKCHTEIIAKLESFNPSASVKDRIAYSMLNSAEED
CCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
GLILPGKTTLIEATSGNTGIALAMVAAAKGYRLILTMPDTMSIERRAMLRAYGAELQLTP
CEEECCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GTEGMRGALELANELSSSIPNSFQFNQFENLANPEIHERTTAKEIWDQSNQNIDGLVSGV
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCC
GTGGTITGCARFLKKVNPNCKIYAVEPAKSAVISGEKPSSHSIQGIGAGFIPKVLNTQLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DEIIKIDDDDAFYYGRLLARLEGLLSGISSGAALAAAIKIGKRKEFIKKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEECCHHH
RYLSTAMFESNTVVQARQDGYL
HHHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]