Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 123965239

GI number: 123965239

Start: 5892

End: 8333

Strand: Reverse

Name: parC [H]

Synonym: P9515_00041

Alternate gene names: 123965239

Gene position: 8333-5892 (Counterclockwise)

Preceding gene: 123965240

Following gene: NA

Centisome position: 0.49

GC content: 26.41

Gene sequence:

>2442_bases
ATGACTAAGGAAAAATTCACTTCCATTTCGCTGCAAGAAGAAATGCAACGTTCCTATCTAGAGTATGCGATGAGCGTGAT
AGTAGGACGTGCATTACCTGATGCTAGAGATGGCTTGAAACCAGTCCAAAGAAGGATCCTTTTCGCAATGCATGAATTAG
GACTTACTCCAGATAGACCATTTAGGAAATGTGCCAGAGTTGTTGGAGATGTACTAGGAAAATATCATCCTCATGGAGAT
CAAGCAGTTTATGAAGCCTTAGTTAGGTTGGTTCAAGATTTTTCAACAAAATATCCCACTCTTGATGGTCATGGGAATTT
TGGATCAGTTGACAATGATCCACCAGCTGCAATGAGATATACCGAAACACGTCTGGCACCAATAGCTCATGAGTGTTTTC
TTCAAGAAATTGAAACTGATACAGTTAGTTACTCAAATAACTTTGATGGCTCACAAAAAGAACCAGATATATTACCTGCC
CAATTACCATTCTTATTATTAAATGGATCATCGGGCATTGCCGTTGGGATGGCTACAAATATTCCTCCACACAATTTGGG
TGAAATTATTGATGGTTTAATTGCACTAATAAGAGATAAAGATATTAGCGACTCAAAATTATCTAAAATCATATTAGGAC
CTGATTTTCCTACAGGAGGAGAATTACTTTACAATAATGGAATTAAAAATGTTTACCTAGAGGGAAGAGGATCCATAACA
ATACGAGGTGTTATTAAAAGTGAAGAAATTAATTTAGGGAAAGGAAAGCATAAAAGAAATGCGCTAATAATATCAGAACT
TCCTTACCAAATTAGTAAAGCCGGTTGGATTGAAAAACTTGCTGAATTAGTAAATATTGGAAAGATTGATGGAATATCTG
ATATTAGGGATGAAAGTGATAGAGATGGAATGAGAATAGTTATTGAATTAAAAAAAGATTCTAATCCTGAAATTGTAATA
TCAAACTTATACAAAAAAACAACATTACAATCAAATTTCGGAGCAATATTATTAGCTTTAGTAAACGGCAAACCCGTACA
ACTTACCCTAAGAAAATATTTAAATTATTTTCTAGAATTTAGAGAAGAAACAATTAGAAAAAGAACAAAATATTTTCTAA
AAATTGCATCAGAAAAACTTGAAATATTAGAAGGATTTTCAATAGCAACTAAAAATATAAAAAATATAATTGAGATTATT
CAAAACTCAGAAAATGTTTCTGAGGCGAAATCAATTTTAATACCAAAGCTTGACCTCAGTAATAAACAAGCAGATGCAGT
CTTAAGCATGCCGCTTAAAAAATTGACAAATTTAGAAAAAAAACAGGTAGAGAATGAAATTAATCAACTTTTTGAGAAAA
AGAAATATCTTAGTACTCTTCTAAATAATAGAAGTTTATTACTTGAAACTTTAATTAAAGAGCTAATTGAATTAAAGAAA
AAATTTAATGTAAAAAGAAAAACAAAAATTTTAAAAGATATTAATCAATCTGAAGAATTAGATACTATTAATAATCAAAT
ATTAGAAGATCTTATAATTAAAGACGCAAAAATATCAATAGATAATAGATTTTATTTTAAAAAATTAATTTACTATAATT
ACAAAAAATTATTAGATCAAGAAAATAAATTTATTGAAAATAAAAATGTTCAAAAATTCATATGTAATATTAAAAAGAGT
TTAAGAATCATAGGAGTAACCTCTTCGGGTAAAGTTCTTCAAATAAATTGGAAATCTATAATTAATAATGTCTATAAATT
AGATAACAAAATTTTAGGAAATATAAATCCAAAAGAAATTATAAATTTTCATGATTTAGACAGTAACTTAGAAAATTATA
TTTGCATTATATGTTCAGATGGAAAATTTAAAAAAGTTTTATTAGATAAAGATATGATTAGAAGTACTAGAATATTTTCC
ATTACAAAGTTGAAAAATTCTACAAAAATTATTGATTCATTTATTTATAGCCAAGAAGAAAATATAATAATACTTACTTC
TATTGGTAGAATTTTTAAATTTAATTTATCTAATGAATATTTAAAGCCAAGTAGCAAACAATCACAGGGAATATTATTAG
TAAATCTATTACCTAAAGAACAAATAGTTTCTTGCTGTAAAAGTAAAGAGAAAGATTTACTTTATTTGATATCAAATAAA
GGCAAATTTTTTGAATTGAAAATTAACGAAGTTTATAATTCTTATAATTCAAAATTAGGATATATTAACGAAAAAATTCA
ACTTAATAATGATCATTTTATAAAAGTTCTAACAAATAATCAATATATCGATTTTGAGACAAATAAAAATAAATCTGCAA
GAATAAATTTAACCAAATTTTCTTCTAAACCTAATAAAAATATACTTAATGTTGATTTTCTCAATTTAGAAAAAGATGAA
TTTCTTGAAAATTGTTCCAGTCTAGATAATCTTTTAAATTAA

Upstream 100 bases:

>100_bases
AAAAATAAATTAAAATTCCTCAATATTTATACTGGAAAATATTTATTTACCTATTAATCTTAATTTAGTTTACCAACGAA
CACTGTAACTTGCCTATTTA

Downstream 100 bases:

>100_bases
AATTTATGATTTATATTCATTTTCAACCCATTTTAAATATTCATGATTTACAGTTCCCGTCACGTAAGAACCTGTAAAAC
AACTCATCTCTAAATCTTTG

Product: DNA gyrase/topoisomerase IV, subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 813; Mature: 812

Protein sequence:

>813_residues
MTKEKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPFRKCARVVGDVLGKYHPHGD
QAVYEALVRLVQDFSTKYPTLDGHGNFGSVDNDPPAAMRYTETRLAPIAHECFLQEIETDTVSYSNNFDGSQKEPDILPA
QLPFLLLNGSSGIAVGMATNIPPHNLGEIIDGLIALIRDKDISDSKLSKIILGPDFPTGGELLYNNGIKNVYLEGRGSIT
IRGVIKSEEINLGKGKHKRNALIISELPYQISKAGWIEKLAELVNIGKIDGISDIRDESDRDGMRIVIELKKDSNPEIVI
SNLYKKTTLQSNFGAILLALVNGKPVQLTLRKYLNYFLEFREETIRKRTKYFLKIASEKLEILEGFSIATKNIKNIIEII
QNSENVSEAKSILIPKLDLSNKQADAVLSMPLKKLTNLEKKQVENEINQLFEKKKYLSTLLNNRSLLLETLIKELIELKK
KFNVKRKTKILKDINQSEELDTINNQILEDLIIKDAKISIDNRFYFKKLIYYNYKKLLDQENKFIENKNVQKFICNIKKS
LRIIGVTSSGKVLQINWKSIINNVYKLDNKILGNINPKEIINFHDLDSNLENYICIICSDGKFKKVLLDKDMIRSTRIFS
ITKLKNSTKIIDSFIYSQEENIIILTSIGRIFKFNLSNEYLKPSSKQSQGILLVNLLPKEQIVSCCKSKEKDLLYLISNK
GKFFELKINEVYNSYNSKLGYINEKIQLNNDHFIKVLTNNQYIDFETNKNKSARINLTKFSSKPNKNILNVDFLNLEKDE
FLENCSSLDNLLN

Sequences:

>Translated_813_residues
MTKEKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPFRKCARVVGDVLGKYHPHGD
QAVYEALVRLVQDFSTKYPTLDGHGNFGSVDNDPPAAMRYTETRLAPIAHECFLQEIETDTVSYSNNFDGSQKEPDILPA
QLPFLLLNGSSGIAVGMATNIPPHNLGEIIDGLIALIRDKDISDSKLSKIILGPDFPTGGELLYNNGIKNVYLEGRGSIT
IRGVIKSEEINLGKGKHKRNALIISELPYQISKAGWIEKLAELVNIGKIDGISDIRDESDRDGMRIVIELKKDSNPEIVI
SNLYKKTTLQSNFGAILLALVNGKPVQLTLRKYLNYFLEFREETIRKRTKYFLKIASEKLEILEGFSIATKNIKNIIEII
QNSENVSEAKSILIPKLDLSNKQADAVLSMPLKKLTNLEKKQVENEINQLFEKKKYLSTLLNNRSLLLETLIKELIELKK
KFNVKRKTKILKDINQSEELDTINNQILEDLIIKDAKISIDNRFYFKKLIYYNYKKLLDQENKFIENKNVQKFICNIKKS
LRIIGVTSSGKVLQINWKSIINNVYKLDNKILGNINPKEIINFHDLDSNLENYICIICSDGKFKKVLLDKDMIRSTRIFS
ITKLKNSTKIIDSFIYSQEENIIILTSIGRIFKFNLSNEYLKPSSKQSQGILLVNLLPKEQIVSCCKSKEKDLLYLISNK
GKFFELKINEVYNSYNSKLGYINEKIQLNNDHFIKVLTNNQYIDFETNKNKSARINLTKFSSKPNKNILNVDFLNLEKDE
FLENCSSLDNLLN
>Mature_812_residues
TKEKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPFRKCARVVGDVLGKYHPHGDQ
AVYEALVRLVQDFSTKYPTLDGHGNFGSVDNDPPAAMRYTETRLAPIAHECFLQEIETDTVSYSNNFDGSQKEPDILPAQ
LPFLLLNGSSGIAVGMATNIPPHNLGEIIDGLIALIRDKDISDSKLSKIILGPDFPTGGELLYNNGIKNVYLEGRGSITI
RGVIKSEEINLGKGKHKRNALIISELPYQISKAGWIEKLAELVNIGKIDGISDIRDESDRDGMRIVIELKKDSNPEIVIS
NLYKKTTLQSNFGAILLALVNGKPVQLTLRKYLNYFLEFREETIRKRTKYFLKIASEKLEILEGFSIATKNIKNIIEIIQ
NSENVSEAKSILIPKLDLSNKQADAVLSMPLKKLTNLEKKQVENEINQLFEKKKYLSTLLNNRSLLLETLIKELIELKKK
FNVKRKTKILKDINQSEELDTINNQILEDLIIKDAKISIDNRFYFKKLIYYNYKKLLDQENKFIENKNVQKFICNIKKSL
RIIGVTSSGKVLQINWKSIINNVYKLDNKILGNINPKEIINFHDLDSNLENYICIICSDGKFKKVLLDKDMIRSTRIFSI
TKLKNSTKIIDSFIYSQEENIIILTSIGRIFKFNLSNEYLKPSSKQSQGILLVNLLPKEQIVSCCKSKEKDLLYLISNKG
KFFELKINEVYNSYNSKLGYINEKIQLNNDHFIKVLTNNQYIDFETNKNKSARINLTKFSSKPNKNILNVDFLNLEKDEF
LENCSSLDNLLN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=175, Percent_Identity=29.7142857142857, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1788562, Length=802, Percent_Identity=35.286783042394, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1789396, Length=683, Percent_Identity=33.8213762811127, Blast_Score=349, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI212645845, Length=475, Percent_Identity=28.4210526315789, Blast_Score=95, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535065, Length=180, Percent_Identity=31.1111111111111, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534553, Length=176, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=386, Percent_Identity=26.6839378238342, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 92951; Mature: 92820

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRP
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
FRKCARVVGDVLGKYHPHGDQAVYEALVRLVQDFSTKYPTLDGHGNFGSVDNDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEE
TETRLAPIAHECFLQEIETDTVSYSNNFDGSQKEPDILPAQLPFLLLNGSSGIAVGMATN
HHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLGEIIDGLIALIRDKDISDSKLSKIILGPDFPTGGELLYNNGIKNVYLEGRGSIT
CCCCHHHHHHHHHHHHHHCCCCCCCHHCEEEECCCCCCCCCEEEECCCCEEEEECCCCEE
IRGVIKSEEINLGKGKHKRNALIISELPYQISKAGWIEKLAELVNIGKIDGISDIRDESD
EEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
RDGMRIVIELKKDSNPEIVISNLYKKTTLQSNFGAILLALVNGKPVQLTLRKYLNYFLEF
CCCCEEEEEEECCCCCCEEEHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHHHHHH
REETIRKRTKYFLKIASEKLEILEGFSIATKNIKNIIEIIQNSENVSEAKSILIPKLDLS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
NKQADAVLSMPLKKLTNLEKKQVENEINQLFEKKKYLSTLLNNRSLLLETLIKELIELKK
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KFNVKRKTKILKDINQSEELDTINNQILEDLIIKDAKISIDNRFYFKKLIYYNYKKLLDQ
HCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCH
ENKFIENKNVQKFICNIKKSLRIIGVTSSGKVLQINWKSIINNVYKLDNKILGNINPKEI
HHHHHCCCCHHHHHHHHHHCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHH
INFHDLDSNLENYICIICSDGKFKKVLLDKDMIRSTRIFSITKLKNSTKIIDSFIYSQEE
EEHHCCCCCCCCEEEEEECCCCEEEEHHCHHHHHHHHEEEEEECCCHHHHHHHHHHCCCC
NIIILTSIGRIFKFNLSNEYLKPSSKQSQGILLVNLLPKEQIVSCCKSKEKDLLYLISNK
CEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEECC
GKFFELKINEVYNSYNSKLGYINEKIQLNNDHFIKVLTNNQYIDFETNKNKSARINLTKF
CCEEEEEHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCEEEEEECCCCCCEEEEEEEE
SSKPNKNILNVDFLNLEKDEFLENCSSLDNLLN
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKEKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRP
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
FRKCARVVGDVLGKYHPHGDQAVYEALVRLVQDFSTKYPTLDGHGNFGSVDNDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEE
TETRLAPIAHECFLQEIETDTVSYSNNFDGSQKEPDILPAQLPFLLLNGSSGIAVGMATN
HHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLGEIIDGLIALIRDKDISDSKLSKIILGPDFPTGGELLYNNGIKNVYLEGRGSIT
CCCCHHHHHHHHHHHHHHCCCCCCCHHCEEEECCCCCCCCCEEEECCCCEEEEECCCCEE
IRGVIKSEEINLGKGKHKRNALIISELPYQISKAGWIEKLAELVNIGKIDGISDIRDESD
EEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
RDGMRIVIELKKDSNPEIVISNLYKKTTLQSNFGAILLALVNGKPVQLTLRKYLNYFLEF
CCCCEEEEEEECCCCCCEEEHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHHHHHH
REETIRKRTKYFLKIASEKLEILEGFSIATKNIKNIIEIIQNSENVSEAKSILIPKLDLS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCC
NKQADAVLSMPLKKLTNLEKKQVENEINQLFEKKKYLSTLLNNRSLLLETLIKELIELKK
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KFNVKRKTKILKDINQSEELDTINNQILEDLIIKDAKISIDNRFYFKKLIYYNYKKLLDQ
HCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCH
ENKFIENKNVQKFICNIKKSLRIIGVTSSGKVLQINWKSIINNVYKLDNKILGNINPKEI
HHHHHCCCCHHHHHHHHHHCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHH
INFHDLDSNLENYICIICSDGKFKKVLLDKDMIRSTRIFSITKLKNSTKIIDSFIYSQEE
EEHHCCCCCCCCEEEEEECCCCEEEEHHCHHHHHHHHEEEEEECCCHHHHHHHHHHCCCC
NIIILTSIGRIFKFNLSNEYLKPSSKQSQGILLVNLLPKEQIVSCCKSKEKDLLYLISNK
CEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEECC
GKFFELKINEVYNSYNSKLGYINEKIQLNNDHFIKVLTNNQYIDFETNKNKSARINLTKF
CCEEEEEHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCEEEEEECCCCCCEEEEEEEE
SSKPNKNILNVDFLNLEKDEFLENCSSLDNLLN
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Isomerization [C]

Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]