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The map label for this gene is cysG [H]

Identifier: 123969436

GI number: 123969436

Start: 1640203

End: 1641006

Strand: Reverse

Name: cysG [H]

Synonym: A9601_19041

Alternate gene names: 123969436

Gene position: 1641006-1640203 (Counterclockwise)

Preceding gene: 123969441

Following gene: 123969425

Centisome position: 98.27

GC content: 32.46

Gene sequence:

>804_bases
GTGCCCGGCATTGTTTATTTAGTTGGAGCAGGTCCTGGTGACCCTGAGCTTCTAACTCTAAAAGCTTTACGCCTAATAAA
AAATTGTGATGCATTAGTACATGATGCTTTGATCCCGGATGAAATAACAAAAGAGGCAGGAAAACATACAGAAATTTTCC
ATGTAGGTAAAAGAGCTGGAAAGTGTTCTGTACCTCAGAAAGAAACTAATGCTCTTATTTTGAAATTGGCAAAAGAAGGC
AAAAATGTTGTAAGGCTTAAAGGGGGAGACCCATTCGTTTTTTCTAGAGGTGGTGAAGAGGTATCAATTTTAGAAAAAAA
TGGAATTTCAGTTGAAATAGTTCCTGGTATTACTTCTGGAATAGCTGCCCCTACATATTTTGGTATTCCACTAACCCATA
GAGATGCTGCGAGTTCCGTAACTTTCGTCACTGGACATGAGCGTGTAGATAAAGAAAAAAAGACAGTGAATTGGAGAGAT
TTAGCTAAATCATCAGATAGCTTAGTAATTTTTATGGGTATAAAAAATATTGAATTTATTGTGGAAGAATTAATTCTAGG
TGGTTTAGATAAGAGTACTAAATGCGCTGTTATTCAAGAAGCTACTTTAAAAAATCAAAAATGTTTGATAGAAAAATTAG
ATAATCTTCCAGATAAAATCAAAGATAAAGAATTTTTAGCTCCATCAATTATCATTATTGGAAAAATTGTTGAATTTAAG
GTTAATAACAATATAACTAAAGTATCTGATGTCTATTTACCAGATATTAATAAAGTTCAACTATATAATAAATCCCAAAA
GTAA

Upstream 100 bases:

>100_bases
GGAGAGTAAATTTTTTATTTGGTTTTAATAAACTTTCTTTCACAATATTTACCTTCATTACCATTAACTTCTACTACCAT
ACTTGTTAATGGAGATTATT

Downstream 100 bases:

>100_bases
ATTGGATCGAATTTAGGTTTAAGCTTTAAATCATCAACTTGATAAATTTGTCTGCAAGATAAGCTATTAATTGCAACTAT
TATGTCATCATTTTGAAATT

Product: putative uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MPGIVYLVGAGPGDPELLTLKALRLIKNCDALVHDALIPDEITKEAGKHTEIFHVGKRAGKCSVPQKETNALILKLAKEG
KNVVRLKGGDPFVFSRGGEEVSILEKNGISVEIVPGITSGIAAPTYFGIPLTHRDAASSVTFVTGHERVDKEKKTVNWRD
LAKSSDSLVIFMGIKNIEFIVEELILGGLDKSTKCAVIQEATLKNQKCLIEKLDNLPDKIKDKEFLAPSIIIIGKIVEFK
VNNNITKVSDVYLPDINKVQLYNKSQK

Sequences:

>Translated_267_residues
MPGIVYLVGAGPGDPELLTLKALRLIKNCDALVHDALIPDEITKEAGKHTEIFHVGKRAGKCSVPQKETNALILKLAKEG
KNVVRLKGGDPFVFSRGGEEVSILEKNGISVEIVPGITSGIAAPTYFGIPLTHRDAASSVTFVTGHERVDKEKKTVNWRD
LAKSSDSLVIFMGIKNIEFIVEELILGGLDKSTKCAVIQEATLKNQKCLIEKLDNLPDKIKDKEFLAPSIIIIGKIVEFK
VNNNITKVSDVYLPDINKVQLYNKSQK
>Mature_266_residues
PGIVYLVGAGPGDPELLTLKALRLIKNCDALVHDALIPDEITKEAGKHTEIFHVGKRAGKCSVPQKETNALILKLAKEGK
NVVRLKGGDPFVFSRGGEEVSILEKNGISVEIVPGITSGIAAPTYFGIPLTHRDAASSVTFVTGHERVDKEKKTVNWRDL
AKSSDSLVIFMGIKNIEFIVEELILGGLDKSTKCAVIQEATLKNQKCLIEKLDNLPDKIKDKEFLAPSIIIIGKIVEFKV
NNNITKVSDVYLPDINKVQLYNKSQK

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=238, Percent_Identity=42.436974789916, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322922, Length=243, Percent_Identity=30.4526748971193, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 29224; Mature: 29093

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGIVYLVGAGPGDPELLTLKALRLIKNCDALVHDALIPDEITKEAGKHTEIFHVGKRAG
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCC
KCSVPQKETNALILKLAKEGKNVVRLKGGDPFVFSRGGEEVSILEKNGISVEIVPGITSG
CCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCEEEEEECCCCEEEEECCCCCC
IAAPTYFGIPLTHRDAASSVTFVTGHERVDKEKKTVNWRDLAKSSDSLVIFMGIKNIEFI
CCCCEEECCCEECCCCCCCEEEEECCHHHCHHHHCCCHHHHHCCCCCEEEEEECCHHHHH
VEELILGGLDKSTKCAVIQEATLKNQKCLIEKLDNLPDKIKDKEFLAPSIIIIGKIVEFK
HHHHHHCCCCCCCEEEEEEHHHHCCHHHHHHHHHCCCHHHCCCHHCCCEEEEEEEEEEEE
VNNNITKVSDVYLPDINKVQLYNKSQK
ECCCCEEEEEEECCCCCEEEEECCCCC
>Mature Secondary Structure 
PGIVYLVGAGPGDPELLTLKALRLIKNCDALVHDALIPDEITKEAGKHTEIFHVGKRAG
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCC
KCSVPQKETNALILKLAKEGKNVVRLKGGDPFVFSRGGEEVSILEKNGISVEIVPGITSG
CCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCEEEEEECCCCEEEEECCCCCC
IAAPTYFGIPLTHRDAASSVTFVTGHERVDKEKKTVNWRDLAKSSDSLVIFMGIKNIEFI
CCCCEEECCCEECCCCCCCEEEEECCHHHCHHHHCCCHHHHHCCCCCEEEEEECCHHHHH
VEELILGGLDKSTKCAVIQEATLKNQKCLIEKLDNLPDKIKDKEFLAPSIIIIGKIVEFK
HHHHHHCCCCCCCEEEEEEHHHHCCHHHHHHHHHCCCHHHCCCHHCCCEEEEEEEEEEEE
VNNNITKVSDVYLPDINKVQLYNKSQK
ECCCCEEEEEEECCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]