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The map label for this gene is gcvT [H]

Identifier: 123969429

GI number: 123969429

Start: 1632069

End: 1633181

Strand: Direct

Name: gcvT [H]

Synonym: A9601_18971

Alternate gene names: 123969429

Gene position: 1632069-1633181 (Clockwise)

Preceding gene: 123969428

Following gene: 123969430

Centisome position: 97.74

GC content: 31.72

Gene sequence:

>1113_bases
ATGGATTTGCTAAAAAGTCCTCTTTATTCAAAATATGTTGAATCCAATGCAAAATTAGTGGATTTTGCAGGTTGGGAAAT
GCCCATATCATTTTCAGGATTAATTAAAGAGCATGAATCAGTTAGATATTCAGCAGGATTATTTGATATTTCTCACATGG
GTGTGATTTCTATCAAGGGAATCAATCCAAAGGATTATATTCAAAAACTTTTTCCTACTAATTTATACTCCTTTTGTGAA
GGTCAGGGGCTTTATACAGTAATGCTCAATGATAAAGGAGGAATAATAGATGACTTAATAATTTATGACCTTGGTATACA
AAAAAATGACATATCAGAATTATTGTTAATAGTTAATGCAAGTAGATATGAAGAAGATTTTCAGTGGATAAAAAATAATT
TAAATATGTCTGAAATTTCGATAACAAACTTTAAAAAAGACAAAGTACTTTTAGCACTACAGGGAAAAAACTCATTCGGT
TTATTTGAAGAATGGATTGAATCTTCGATCTCACATATCCCTAACTTTGGATGCGAATATAAAATTTTTGAACATATTTC
CCCTAAGGAAAAAATTTTCTTTTCAAAGACAGGCTATACGGGGGAAAATGGTCTAGAAATACTTTTATCTAAAAAAGCAG
CAATTAATTTATGGGATTTCTTAATTTCTAAAAATGTTGCACCTTGTGGTTTAGGAGCTAGAGATACTCTTAGACTTGAA
GCAGGCATGCATCTTTATGGGCAAGACATAAATGAAGAAACTTCTCCATATGAAGCAGGGTTAGGATGGCTAGTACATCT
AGAAAATAATCACGAATTCATTGGCAGAAGAGTTCTTGAAGAACAGTCAAGATTAGGCATTCAAAAAAAGTTAGTTGGTC
TCTCTATAAAAGGTAAAGCAATAGGAAGAAAAGGGTGCGCAGTGCTTAAAGGTGATGAAAATATTGGAACTATCACTAGC
GGCAGTTGGTCTCCAACTAAACATCAAGCTATTGCTTTTGCATACATCAATACTTCGCATGCCTTAATAAATAATGAAGT
TGAAATATTAATAAGAGGCAAAAAATTCAACGGGGTTATAACAAAAAGAGCGTTTTATAAAAAGAATTATTAA

Upstream 100 bases:

>100_bases
CAGCCAAAGTACTTAGAAGCTTAATTTTGTCATTAGAAAATATGCAATAAAAAATTTCTAAACTAAAGTGTATAAATACT
AAATAGAAACTAAATATTTC

Downstream 100 bases:

>100_bases
CTAAATTTGCCCTTAAAGAATTATTATAAGTTATTGATAAATAAACCATACTTAGATGAGAAACAAAATTTGTGAAGAAC
TCAATAATACAGATATTGGT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MDLLKSPLYSKYVESNAKLVDFAGWEMPISFSGLIKEHESVRYSAGLFDISHMGVISIKGINPKDYIQKLFPTNLYSFCE
GQGLYTVMLNDKGGIIDDLIIYDLGIQKNDISELLLIVNASRYEEDFQWIKNNLNMSEISITNFKKDKVLLALQGKNSFG
LFEEWIESSISHIPNFGCEYKIFEHISPKEKIFFSKTGYTGENGLEILLSKKAAINLWDFLISKNVAPCGLGARDTLRLE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFIGRRVLEEQSRLGIQKKLVGLSIKGKAIGRKGCAVLKGDENIGTITS
GSWSPTKHQAIAFAYINTSHALINNEVEILIRGKKFNGVITKRAFYKKNY

Sequences:

>Translated_370_residues
MDLLKSPLYSKYVESNAKLVDFAGWEMPISFSGLIKEHESVRYSAGLFDISHMGVISIKGINPKDYIQKLFPTNLYSFCE
GQGLYTVMLNDKGGIIDDLIIYDLGIQKNDISELLLIVNASRYEEDFQWIKNNLNMSEISITNFKKDKVLLALQGKNSFG
LFEEWIESSISHIPNFGCEYKIFEHISPKEKIFFSKTGYTGENGLEILLSKKAAINLWDFLISKNVAPCGLGARDTLRLE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFIGRRVLEEQSRLGIQKKLVGLSIKGKAIGRKGCAVLKGDENIGTITS
GSWSPTKHQAIAFAYINTSHALINNEVEILIRGKKFNGVITKRAFYKKNY
>Mature_370_residues
MDLLKSPLYSKYVESNAKLVDFAGWEMPISFSGLIKEHESVRYSAGLFDISHMGVISIKGINPKDYIQKLFPTNLYSFCE
GQGLYTVMLNDKGGIIDDLIIYDLGIQKNDISELLLIVNASRYEEDFQWIKNNLNMSEISITNFKKDKVLLALQGKNSFG
LFEEWIESSISHIPNFGCEYKIFEHISPKEKIFFSKTGYTGENGLEILLSKKAAINLWDFLISKNVAPCGLGARDTLRLE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFIGRRVLEEQSRLGIQKKLVGLSIKGKAIGRKGCAVLKGDENIGTITS
GSWSPTKHQAIAFAYINTSHALINNEVEILIRGKKFNGVITKRAFYKKNY

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=380, Percent_Identity=28.4210526315789, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI257796258, Length=351, Percent_Identity=28.7749287749288, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI257796254, Length=374, Percent_Identity=26.7379679144385, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI257796256, Length=300, Percent_Identity=28.6666666666667, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI24797151, Length=392, Percent_Identity=22.9591836734694, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI197927446, Length=333, Percent_Identity=21.9219219219219, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21361378, Length=333, Percent_Identity=21.9219219219219, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI194306651, Length=404, Percent_Identity=22.7722772277228, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=36.3636363636364, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17560118, Length=382, Percent_Identity=30.8900523560209, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71994045, Length=380, Percent_Identity=23.4210526315789, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994052, Length=380, Percent_Identity=23.4210526315789, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32563613, Length=400, Percent_Identity=23.5, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=28.6445012787724, Blast_Score=156, Evalue=5e-39,
Organism=Drosophila melanogaster, GI20129441, Length=381, Percent_Identity=30.7086614173228, Blast_Score=178, Evalue=5e-45,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41680; Mature: 41680

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLKSPLYSKYVESNAKLVDFAGWEMPISFSGLIKEHESVRYSAGLFDISHMGVISIKG
CCCHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHCCEEECCEEEECCCCEEEEEC
INPKDYIQKLFPTNLYSFCEGQGLYTVMLNDKGGIIDDLIIYDLGIQKNDISELLLIVNA
CCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHEEEEEEC
SRYEEDFQWIKNNLNMSEISITNFKKDKVLLALQGKNSFGLFEEWIESSISHIPNFGCEY
HHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
KIFEHISPKEKIFFSKTGYTGENGLEILLSKKAAINLWDFLISKNVAPCGLGARDTLRLE
EHHHCCCCCHHEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFIGRRVLEEQSRLGIQKKLVGLSIKGKA
CCCEEECCCCCCCCCCHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHEEEEEECCC
IGRKGCAVLKGDENIGTITSGSWSPTKHQAIAFAYINTSHALINNEVEILIRGKKFNGVI
CCCCCCEEEECCCCCCEEECCCCCCCCCCEEEEEEEECCCEEECCCEEEEEECCCCCCEE
TKRAFYKKNY
EEHHHHCCCC
>Mature Secondary Structure
MDLLKSPLYSKYVESNAKLVDFAGWEMPISFSGLIKEHESVRYSAGLFDISHMGVISIKG
CCCHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHCCEEECCEEEECCCCEEEEEC
INPKDYIQKLFPTNLYSFCEGQGLYTVMLNDKGGIIDDLIIYDLGIQKNDISELLLIVNA
CCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCEEEEEECCCCCCCHHHEEEEEEC
SRYEEDFQWIKNNLNMSEISITNFKKDKVLLALQGKNSFGLFEEWIESSISHIPNFGCEY
HHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
KIFEHISPKEKIFFSKTGYTGENGLEILLSKKAAINLWDFLISKNVAPCGLGARDTLRLE
EHHHCCCCCHHEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEE
AGMHLYGQDINEETSPYEAGLGWLVHLENNHEFIGRRVLEEQSRLGIQKKLVGLSIKGKA
CCCEEECCCCCCCCCCHHCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHEEEEEECCC
IGRKGCAVLKGDENIGTITSGSWSPTKHQAIAFAYINTSHALINNEVEILIRGKKFNGVI
CCCCCCEEEECCCCCCEEECCCCCCCCCCEEEEEEEECCCEEECCCEEEEEECCCCCCEE
TKRAFYKKNY
EEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA