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The map label for this gene is sam1 [H]

Identifier: 123969367

GI number: 123969367

Start: 1565846

End: 1567279

Strand: Reverse

Name: sam1 [H]

Synonym: A9601_18351

Alternate gene names: 123969367

Gene position: 1567279-1565846 (Counterclockwise)

Preceding gene: 123969369

Following gene: 123969366

Centisome position: 93.86

GC content: 35.91

Gene sequence:

>1434_bases
ATGTATTTACTAGATATGGTTATCGCAAATTCAGTTAAAACCTCTACACCAAATTATGTAATTGCTGATATCTCCTTATC
AGATTTTGGCCGTAAAGAAATTAAAATTGCCGAAACGGAAATGCCTGGATTAATGGCACTTAGAGATAAATATCAATCAG
AAAAGCCACTAAAAGGTGCAAAAATAGCCGGAAGTTTGCATATGACTATTCAGACTGCAGTCTTAATAGAAACTCTTGTT
GATCTTGGGGCAGAAGTGAAATGGGCTTCATGCAATATTTTTTCAACTCAAGATCATGCGGCGGCGGCTATTGCAGATCA
AGGAATTCCTGTATACGCAAAAAAAGGTGAGACACTTGATGAATATTGGCAATATACCCACTACATTCTTGATTGGGGTT
CAGACTCTCCAAATATGATTCTTGATGATGGTGGGGATGCAACTGGTTTATTGATACTCGGCAGTAAAGCGGAAAAAGAT
TTGTCTGTTTTAGATAATCCTGGTAATGAAGAAGAAATTGCTTTATTCAACTCTATTAAATCTAAATTAGAAAATGATAG
TGACTTCTATTCTAGAATTAAAAGTAATATCATTGGTGTCACTGAAGAAACTACGACAGGAGTTGCAAGACTGTATCAAC
TGCAAAAGCAAAATGCTTTACCTTTCCCTGCGATCAACGTTAATGATTCAGTAACTAAGAGCAAATTTGATAATTTATAT
GGCTGTCGCGAATCTTTAGTTGATAGTATAAAGCGCGCAACTGATGTGATGATTGCTGGTAAGGTTGCTTTGGTAATGGG
TTTTGGAGATGTAGGTAAAGGTTCAGCCCAGTCATTGCGTGGACTTGGTGCAATCGTAAAAGTTGCTGAAGTTGATCCAA
TTTGTGCTCTTCAAGCGGCAATGGAAGGTTTTAGCGTTGTTACGTTAGACGATGTTGTGGAGGATATAGATATCTTTGTT
ACAGCAACTGGGAATTATCAAGTAATTACAAATGAAAATCTCGTCAAGATGAAAGATGAGGCCATAGTTTGTAATATTGG
TCATTTCGATAATGAAATTGATGTGGCTTCATTGAAAGATTATCCATGGGAAAATATTAAGCCGCAGGTTGATCACATAA
CTTTACCGAGTGGCAATAAAATAATTCTTTTAGCCGAAGGTAGATTAGTTAACTTAGGCTGTGCCACTGGACATCCAAGT
TTTGTTATGAGTAATTCTTTTACTAACCAAGTATTAGCTCAAATCGAACTTTTCAATAAGTCAGAGCAATATGCGAAAGA
GGTTTATGTTTTACCAAAGCATTTAGATGAAATGGTAGCTAGATTACATCTTGATAAAATTGGTGCAAAATTAACAACAT
TAACTAAGGAACAAGCTGACTATATTAATGTCTCTGTTGAAGGACCTTACAAACCAGAGCTTTATAGATACTAA

Upstream 100 bases:

>100_bases
GATTTAATTTGTGTGAGAGTTTTTTTCCTAAATTTAAAGTTTCTTTTAAATTTTCAACAAACACAAAATTACACAAAAAT
CATTTATAGTCTAATAATAA

Downstream 100 bases:

>100_bases
GTTTGAGTTTAATTTTTGTAAATTTTCTTACTTCAATTCCCGACTATATTAGTTTAGCTGTTGAAAAGAATTCAACAATT
GCATACCTCACTATTTGTTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MYLLDMVIANSVKTSTPNYVIADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLV
DLGAEVKWASCNIFSTQDHAAAAIADQGIPVYAKKGETLDEYWQYTHYILDWGSDSPNMILDDGGDATGLLILGSKAEKD
LSVLDNPGNEEEIALFNSIKSKLENDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLY
GCRESLVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLDDVVEDIDIFV
TATGNYQVITNENLVKMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPS
FVMSNSFTNQVLAQIELFNKSEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTTLTKEQADYINVSVEGPYKPELYRY

Sequences:

>Translated_477_residues
MYLLDMVIANSVKTSTPNYVIADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLV
DLGAEVKWASCNIFSTQDHAAAAIADQGIPVYAKKGETLDEYWQYTHYILDWGSDSPNMILDDGGDATGLLILGSKAEKD
LSVLDNPGNEEEIALFNSIKSKLENDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLY
GCRESLVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLDDVVEDIDIFV
TATGNYQVITNENLVKMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPS
FVMSNSFTNQVLAQIELFNKSEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTTLTKEQADYINVSVEGPYKPELYRY
>Mature_477_residues
MYLLDMVIANSVKTSTPNYVIADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGAKIAGSLHMTIQTAVLIETLV
DLGAEVKWASCNIFSTQDHAAAAIADQGIPVYAKKGETLDEYWQYTHYILDWGSDSPNMILDDGGDATGLLILGSKAEKD
LSVLDNPGNEEEIALFNSIKSKLENDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLY
GCRESLVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLDDVVEDIDIFV
TATGNYQVITNENLVKMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPS
FVMSNSFTNQVLAQIELFNKSEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTTLTKEQADYINVSVEGPYKPELYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=461, Percent_Identity=58.7852494577007, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI239937451, Length=439, Percent_Identity=58.997722095672, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=49.6774193548387, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI24308043, Length=463, Percent_Identity=49.8920086393089, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI195539337, Length=463, Percent_Identity=49.8920086393089, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=49.6774193548387, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=47.9569892473118, Blast_Score=437, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17506425, Length=473, Percent_Identity=57.9281183932347, Blast_Score=508, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=56.6945606694561, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=60.3004291845494, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24656245, Length=452, Percent_Identity=51.3274336283186, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45553387, Length=462, Percent_Identity=50, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553385, Length=461, Percent_Identity=49.8915401301518, Blast_Score=437, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52364; Mature: 52364

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLLDMVIANSVKTSTPNYVIADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGA
CEEEEEEHHCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCC
KIAGSLHMTIQTAVLIETLVDLGAEVKWASCNIFSTQDHAAAAIADQGIPVYAKKGETLD
EEECEEEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCCEEEECCCCCHH
EYWQYTHYILDWGSDSPNMILDDGGDATGLLILGSKAEKDLSVLDNPGNEEEIALFNSIK
HHHHHEEEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHH
SKLENDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLY
HHHCCCHHHHHHHHHCEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHH
GCRESLVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAA
HHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHH
MEGFSVVTLDDVVEDIDIFVTATGNYQVITNENLVKMKDEAIVCNIGHFDNEIDVASLKD
HCCCEEEEHHHHHCCEEEEEEECCCEEEEECCCEEEEECCEEEEEECCCCCCCCEEECCC
YPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFNK
CCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCC
SEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTTLTKEQADYINVSVEGPYKPELYRY
CHHHHHHHEECHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MYLLDMVIANSVKTSTPNYVIADISLSDFGRKEIKIAETEMPGLMALRDKYQSEKPLKGA
CEEEEEEHHCCCCCCCCCEEEEEEEHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCC
KIAGSLHMTIQTAVLIETLVDLGAEVKWASCNIFSTQDHAAAAIADQGIPVYAKKGETLD
EEECEEEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHCCCCEEEECCCCCHH
EYWQYTHYILDWGSDSPNMILDDGGDATGLLILGSKAEKDLSVLDNPGNEEEIALFNSIK
HHHHHEEEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHH
SKLENDSDFYSRIKSNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLY
HHHCCCHHHHHHHHHCEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHH
GCRESLVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAA
HHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHH
MEGFSVVTLDDVVEDIDIFVTATGNYQVITNENLVKMKDEAIVCNIGHFDNEIDVASLKD
HCCCEEEEHHHHHCCEEEEEEECCCEEEEECCCEEEEECCEEEEEECCCCCCCCEEECCC
YPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFNK
CCCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCC
SEQYAKEVYVLPKHLDEMVARLHLDKIGAKLTTLTKEQADYINVSVEGPYKPELYRY
CHHHHHHHEECHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA