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The map label for this gene is ilvC [H]

Identifier: 123969046

GI number: 123969046

Start: 1297670

End: 1298659

Strand: Direct

Name: ilvC [H]

Synonym: A9601_15141

Alternate gene names: 123969046

Gene position: 1297670-1298659 (Clockwise)

Preceding gene: 123969045

Following gene: 123969047

Centisome position: 77.71

GC content: 37.78

Gene sequence:

>990_bases
ATGACCCAACTCTTTTACGACACAGATGCTGATCTAAGTCTTTTAAATAATAAAACAATAGCGATTATTGGATATGGTTC
ACAAGGTCATGCACATGCCCTAAACCTTAAAGATAGCGGTATGGATGTAATTGTTGGATTATATAAAGGAAGTAAGTCTG
AGAGCAAAGCTATTAGCGATGGACTACAAGTATTTAGCGTTTCTGAAGCTTGCGAAAAAGCAGATTGGATTATGATTCTC
CTCCCAGATGAGTTTCAGAAAGATGTTTACCTTAAAGAAATAGAACCAAACTTAAAAGAAGGAAAGATATTAAGTTTTGC
TCATGGCTTCAATATCAGATTCGGACTTATCAAACCTCCTAGTTTTGTGGATGTTGTAATGATTGCCCCAAAAGGACCTG
GACACACTGTTCGTTGGGAATATCAGAATGGTCAAGGAGTTCCAGCATTGTTTGCCGTAGAGCAGGATTCTTCAGGGAAT
GCAAGATCATTGGCGATGGCTTACGCAAAAGGGATTGGCGGAACGAGAGCTGGGATTCTTGAAACAAACTTCAAAGAAGA
AACAGAAACTGATTTATTTGGAGAACAAGCAGTTTTGTGCGGAGGGTTATCAGAACTCGTCAAATCAGGATTCGAAACTC
TTGTAGAGGCAGGCTATCAGCCCGAACTTGCTTACTTCGAATGCTTACATGAAGTTAAACTTATTGTTGATTTAATGGTG
AAGGGAGGCTTATCTCAAATGAGAGATTCCATTTCAAATACTGCAGAATATGGAGATTATGTAAGTGGTAAAAGACTTAT
CAATAGTGATACAAAGAAAGAAATGCAGAAAATTCTAAAGGATATTCAAGATGGTACTTTCGCTAAGAATTTTGTGGAAG
AATGCGATAAGAACAAACCCTTAATGACAAAATTAAGAGAAGAGAACTCAAAACATGAAATTGAGAAAGTGGGTAAAGGT
CTGCGCTCGATGTTCAGTTGGCTGAAATAA

Upstream 100 bases:

>100_bases
TTAATATTTTAATTTTAATTTTTAAATTAATAATTATTTAGTTTATTTACACCTTTAAAGTCTAAAATATTAATTATTAA
ATGCAAAGAAACTACAACTA

Downstream 100 bases:

>100_bases
ATTTATTTTTACTATTTCTTGGATCAATTGGTTTTGATTTATTGTTAGGCGATCCAAAATTCTTAATACACCCTGTTCAA
GTAATTGGCTTTTACATAAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISDGLQVFSVSEACEKADWIMIL
LPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGN
ARSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKNKPLMTKLREENSKHEIEKVGKG
LRSMFSWLK

Sequences:

>Translated_329_residues
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISDGLQVFSVSEACEKADWIMIL
LPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGN
ARSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKNKPLMTKLREENSKHEIEKVGKG
LRSMFSWLK
>Mature_328_residues
TQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISDGLQVFSVSEACEKADWIMILL
PDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGNA
RSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMVK
GGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKNKPLMTKLREENSKHEIEKVGKGL
RSMFSWLK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=312, Percent_Identity=35.8974358974359, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=33.9506172839506, Blast_Score=152, Evalue=6e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36401; Mature: 36270

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISD
CCEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHH
GLQVFSVSEACEKADWIMILLPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPP
HHHHEEHHHHHHCCCEEEEEECCCCCCCEEHHHCCCCCCCCCEEEEECCCEEEEEEECCC
SFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGNARSLAMAYAKGIGGTRAGIL
CCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKNKP
HCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
LMTKLREENSKHEIEKVGKGLRSMFSWLK
HHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAISD
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHH
GLQVFSVSEACEKADWIMILLPDEFQKDVYLKEIEPNLKEGKILSFAHGFNIRFGLIKPP
HHHHEEHHHHHHCCCEEEEEECCCCCCCEEHHHCCCCCCCCCEEEEECCCEEEEEEECCC
SFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDSSGNARSLAMAYAKGIGGTRAGIL
CCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDKNKP
HCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
LMTKLREENSKHEIEKVGKGLRSMFSWLK
HHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA