| Definition | Prochlorococcus marinus str. AS9601, complete genome. |
|---|---|
| Accession | NC_008816 |
| Length | 1,669,886 |
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The map label for this gene is folC [H]
Identifier: 123969033
GI number: 123969033
Start: 1283829
End: 1285061
Strand: Direct
Name: folC [H]
Synonym: A9601_15011
Alternate gene names: 123969033
Gene position: 1283829-1285061 (Clockwise)
Preceding gene: 123969032
Following gene: 123969036
Centisome position: 76.88
GC content: 30.17
Gene sequence:
>1233_bases TTGAAAAATGCAAATTTAAAAATTTTTGAATTATTATCTCCTAAATACGAAAGGGATAATATCAAATTAGGTTTATCAAG AATTAAAAAAGCACTTCAAGAACTTGGTAATCCCTGCGGAAATGTCCCTGCGATACAAATTATTGGAACCAATGGGAAAG GATCAATCGCAGCATATATAGAGAGTATACTTTTTGAAGCTAAAAAGAATTTTGGTGTAACGACATCTCCTCATCTTTTT GACGTATGCGAAAGGATTAGAGTAAATAAAAAAAATATCAGCAAAACTGATTTTGAAAAAATCTATAAATTAATAGAAAC AAAATTTTCAAAATTTGAATTAACACCTTTTGAAAAAATTATTTGCTGCGCACTTAATTTTTTTGATAATAAAAAAGTTG AATTGCTCATTCTTGAAGCTGGCTTAGGGGGACGATTAGACGCGACAACAGCTCATAAATCTAGACCAATAATTGCTATT GGGAATATTGGCTTAGACCATAAGGAATTTCTTGGAGATACGATTGAAAAAATTGCCAAAGAAAAATTAGCAGTTATTGA ACAAAATTCAATTGTTATCTCATGCCACCAAAATAGTAAAGTTGAAAATTTAATAACCAAAAAAGTTAAAGAGGCAGGTG CAGCAATTATTTGGAAAGATTCAATTTCAAACAGCTATGAGCTTGGATTAAAAGGAATTTTTCAAAAGCAAAATGCTTCA GTAGCTGTTGGAGCAATTGAAGCGCTGAATAATTTGGGATTCAATATAAAAGAAAAACATATATCTGAAGGTCTTAAAAA GACAACTTGGAACGGAAGGCTAGAAATAATAAATTATTTAAACAAAGAAATTCTTGTAGATTGTGCGCATAATTATCCTG CTGCAAAAGCACTCTCTAATGAGCGAAGCAATTGGGAGAATGAAGATAAAGGAATTTATTGGATTTTAGGTGTCCAAAGA CAAAAAGATATTTACGCAATATTAAAAACACTTCTAAAGAAAAATGATCACTTATTACTTGTGCCAGTTCCAAACCAACC TTGTTGGCAATTAAATGATCTCTCTCAGATTAAAGAAATTGACTTTCAAAAAATAATTGAATTTAAAAAATTTGAACATG CCATTGAGTATTTATTTTCCCTGGAAACATGGCCACCTAATCATCCTGTTGTAACAGGTTCTATTTTTTTAGTTGCTGAA TTTATTAAATTTGCGTATAAACAGAAATTCTAA
Upstream 100 bases:
>100_bases TCGTAAGAATTGTCCCACCATTAGTTATATCTCGAAGAGAAATTAATATTCTTTTGAATAAGCTAAATTCAATTTTTGAA GAGTTATAACAATTTAAATT
Downstream 100 bases:
>100_bases ATTTTAAATTGTTCTCTTACTTCCCAACCTTCCAATTTCCCTGGATTTAATAGCCCTTTTGGATCAAATCTTAATTTCGC TTTTACTTGATCTGCATCCA
Product: putative bifunctional dihydrofolate/folylpolyglutamate synthase
Products: NA
Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase [H]
Number of amino acids: Translated: 410; Mature: 410
Protein sequence:
>410_residues MKNANLKIFELLSPKYERDNIKLGLSRIKKALQELGNPCGNVPAIQIIGTNGKGSIAAYIESILFEAKKNFGVTTSPHLF DVCERIRVNKKNISKTDFEKIYKLIETKFSKFELTPFEKIICCALNFFDNKKVELLILEAGLGGRLDATTAHKSRPIIAI GNIGLDHKEFLGDTIEKIAKEKLAVIEQNSIVISCHQNSKVENLITKKVKEAGAAIIWKDSISNSYELGLKGIFQKQNAS VAVGAIEALNNLGFNIKEKHISEGLKKTTWNGRLEIINYLNKEILVDCAHNYPAAKALSNERSNWENEDKGIYWILGVQR QKDIYAILKTLLKKNDHLLLVPVPNQPCWQLNDLSQIKEIDFQKIIEFKKFEHAIEYLFSLETWPPNHPVVTGSIFLVAE FIKFAYKQKF
Sequences:
>Translated_410_residues MKNANLKIFELLSPKYERDNIKLGLSRIKKALQELGNPCGNVPAIQIIGTNGKGSIAAYIESILFEAKKNFGVTTSPHLF DVCERIRVNKKNISKTDFEKIYKLIETKFSKFELTPFEKIICCALNFFDNKKVELLILEAGLGGRLDATTAHKSRPIIAI GNIGLDHKEFLGDTIEKIAKEKLAVIEQNSIVISCHQNSKVENLITKKVKEAGAAIIWKDSISNSYELGLKGIFQKQNAS VAVGAIEALNNLGFNIKEKHISEGLKKTTWNGRLEIINYLNKEILVDCAHNYPAAKALSNERSNWENEDKGIYWILGVQR QKDIYAILKTLLKKNDHLLLVPVPNQPCWQLNDLSQIKEIDFQKIIEFKKFEHAIEYLFSLETWPPNHPVVTGSIFLVAE FIKFAYKQKF >Mature_410_residues MKNANLKIFELLSPKYERDNIKLGLSRIKKALQELGNPCGNVPAIQIIGTNGKGSIAAYIESILFEAKKNFGVTTSPHLF DVCERIRVNKKNISKTDFEKIYKLIETKFSKFELTPFEKIICCALNFFDNKKVELLILEAGLGGRLDATTAHKSRPIIAI GNIGLDHKEFLGDTIEKIAKEKLAVIEQNSIVISCHQNSKVENLITKKVKEAGAAIIWKDSISNSYELGLKGIFQKQNAS VAVGAIEALNNLGFNIKEKHISEGLKKTTWNGRLEIINYLNKEILVDCAHNYPAAKALSNERSNWENEDKGIYWILGVQR QKDIYAILKTLLKKNDHLLLVPVPNQPCWQLNDLSQIKEIDFQKIIEFKKFEHAIEYLFSLETWPPNHPVVTGSIFLVAE FIKFAYKQKF
Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]
COG id: COG0285
COG function: function code H; Folylpolyglutamate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the folylpolyglutamate synthase family [H]
Homologues:
Organism=Homo sapiens, GI66932990, Length=320, Percent_Identity=26.5625, Blast_Score=110, Evalue=3e-24, Organism=Homo sapiens, GI66932984, Length=289, Percent_Identity=27.681660899654, Blast_Score=110, Evalue=3e-24, Organism=Escherichia coli, GI1788654, Length=345, Percent_Identity=27.536231884058, Blast_Score=114, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17553148, Length=325, Percent_Identity=24.6153846153846, Blast_Score=99, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17553150, Length=325, Percent_Identity=24.6153846153846, Blast_Score=99, Evalue=6e-21, Organism=Caenorhabditis elegans, GI71984923, Length=325, Percent_Identity=24.6153846153846, Blast_Score=98, Evalue=6e-21, Organism=Saccharomyces cerevisiae, GI6323760, Length=420, Percent_Identity=30.7142857142857, Blast_Score=164, Evalue=2e-41, Organism=Saccharomyces cerevisiae, GI6324815, Length=319, Percent_Identity=28.5266457680251, Blast_Score=99, Evalue=2e-21, Organism=Saccharomyces cerevisiae, GI6322718, Length=279, Percent_Identity=26.1648745519713, Blast_Score=77, Evalue=4e-15, Organism=Drosophila melanogaster, GI24581568, Length=177, Percent_Identity=31.0734463276836, Blast_Score=93, Evalue=3e-19, Organism=Drosophila melanogaster, GI24641571, Length=357, Percent_Identity=25.4901960784314, Blast_Score=92, Evalue=5e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR018109 - InterPro: IPR001645 - InterPro: IPR004101 - InterPro: IPR013221 [H]
Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.17 [H]
Molecular weight: Translated: 46473; Mature: 46473
Theoretical pI: Translated: 9.44; Mature: 9.44
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 0.2 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 0.2 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKNANLKIFELLSPKYERDNIKLGLSRIKKALQELGNPCGNVPAIQIIGTNGKGSIAAYI CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHH ESILFEAKKNFGVTTSPHLFDVCERIRVNKKNISKTDFEKIYKLIETKFSKFELTPFEKI HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEECCHHHHH ICCALNFFDNKKVELLILEAGLGGRLDATTAHKSRPIIAIGNIGLDHKEFLGDTIEKIAK HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH EKLAVIEQNSIVISCHQNSKVENLITKKVKEAGAAIIWKDSISNSYELGLKGIFQKQNAS HHHHEEECCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHCHHHHHHCCCCC VAVGAIEALNNLGFNIKEKHISEGLKKTTWNGRLEIINYLNKEILVDCAHNYPAAKALSN EEHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHEEHHHCCCCHHHHHHC ERSNWENEDKGIYWILGVQRQKDIYAILKTLLKKNDHLLLVPVPNQPCWQLNDLSQIKEI CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHC DFQKIIEFKKFEHAIEYLFSLETWPPNHPVVTGSIFLVAEFIKFAYKQKF CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MKNANLKIFELLSPKYERDNIKLGLSRIKKALQELGNPCGNVPAIQIIGTNGKGSIAAYI CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHH ESILFEAKKNFGVTTSPHLFDVCERIRVNKKNISKTDFEKIYKLIETKFSKFELTPFEKI HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEECCHHHHH ICCALNFFDNKKVELLILEAGLGGRLDATTAHKSRPIIAIGNIGLDHKEFLGDTIEKIAK HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH EKLAVIEQNSIVISCHQNSKVENLITKKVKEAGAAIIWKDSISNSYELGLKGIFQKQNAS HHHHEEECCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHCHHHHHHCCCCC VAVGAIEALNNLGFNIKEKHISEGLKKTTWNGRLEIINYLNKEILVDCAHNYPAAKALSN EEHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHEEHHHCCCCHHHHHHC ERSNWENEDKGIYWILGVQRQKDIYAILKTLLKKNDHLLLVPVPNQPCWQLNDLSQIKEI CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHC DFQKIIEFKKFEHAIEYLFSLETWPPNHPVVTGSIFLVAEFIKFAYKQKF CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8419299; 9384377; 2553669 [H]