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The map label for this gene is argF [H]

Identifier: 123968994

GI number: 123968994

Start: 1246475

End: 1247401

Strand: Reverse

Name: argF [H]

Synonym: A9601_14621

Alternate gene names: 123968994

Gene position: 1247401-1246475 (Counterclockwise)

Preceding gene: 123968995

Following gene: 123968993

Centisome position: 74.7

GC content: 33.76

Gene sequence:

>927_bases
ATGTTAAATCCGATCAAGCTTGCAAGTAAAAATTTCTTATCAAGCTTGGATACTTCACTTGAAGAATTTCTTCATATTTT
AGAGTTAGCCAAAAATTTTAAAAATAAAGATCTAAGTATAAAACTCCAAGAAAAAGTTTTAGGGTTAATTTTTGATAAGT
CATCAACTCGCACCAGAGTTAGCTTCCAAGTGGCAATGTCAAGACTTGGTGGCACCACAGTTGACCTAAATCCTACTACT
TCACAAATTGGGAGGGGAGAGCCAATCAGAGATACAGCAAGAGTGCTAAGTAGATACTGCGATGTTCTTGCGATAAGAAC
GTTTAAACAAACTGATTTGGAAGAGTACGCAAAATGGTCCTCTAAACCAATTATTAATGCTCTTACTGATTTAGAACATC
CATGTCAGGCACTAGCTGATTTTATGACAATTAAAGAGGAATTTCTTGATTTTAACGATGTAGTTTTGACATTTATTGGA
GACGGTAATAACGTCGCAAATTCTCTTATTTTATGTGGCGCGTTATTAGGAGTAGAAGTTAGGATTGCATGCCCTAAAGG
TTATGAACCTAACTCGTTGTTAATTGATAAAGCATATGAAATATATGAAAATAAGAATTTGTTGAAAATCACTAATGAAC
CCAACACCGCTGTTTTAGGAGCAAATGTTCTTTATACAGATGTTTGGTCATCTATGGGTGAAGAAAATCAAAAAGATGAG
AAAGAAAAAGTTTTTAATGGTTTTACTATTGACAGAGATTTAGTTAGTAAGGCCGATAAAGATGCAATTATTCTTCATTG
CCTTCCTGCCTATAGATCCAAAGAGATAACTGATGAAATATTTGAAAGTCACAAAAGTAGAATTTTTGATCAAGCGGAAA
ATAGATTACATGCTCAACAAGCTCTTTTATCTTGCATTCTCCAATAG

Upstream 100 bases:

>100_bases
ATTCTCCAAGAAGAAGTTATAGAGGGTGAGGATCTTAAAACCCTCTTGGCAGAGAGTAAGATGCCAGCATAGTAGAATTT
GGGTTTTAGTATAAAGTTAG

Downstream 100 bases:

>100_bases
AAATACTTGCGAACTAATTAAAAAAAAGGTACAAATGTATTAGAGTACATATGTTTTATGGATGCTTCTTCAGGCGACCA
GCTGACCCAAGCTCAGGATG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MLNPIKLASKNFLSSLDTSLEEFLHILELAKNFKNKDLSIKLQEKVLGLIFDKSSTRTRVSFQVAMSRLGGTTVDLNPTT
SQIGRGEPIRDTARVLSRYCDVLAIRTFKQTDLEEYAKWSSKPIINALTDLEHPCQALADFMTIKEEFLDFNDVVLTFIG
DGNNVANSLILCGALLGVEVRIACPKGYEPNSLLIDKAYEIYENKNLLKITNEPNTAVLGANVLYTDVWSSMGEENQKDE
KEKVFNGFTIDRDLVSKADKDAIILHCLPAYRSKEITDEIFESHKSRIFDQAENRLHAQQALLSCILQ

Sequences:

>Translated_308_residues
MLNPIKLASKNFLSSLDTSLEEFLHILELAKNFKNKDLSIKLQEKVLGLIFDKSSTRTRVSFQVAMSRLGGTTVDLNPTT
SQIGRGEPIRDTARVLSRYCDVLAIRTFKQTDLEEYAKWSSKPIINALTDLEHPCQALADFMTIKEEFLDFNDVVLTFIG
DGNNVANSLILCGALLGVEVRIACPKGYEPNSLLIDKAYEIYENKNLLKITNEPNTAVLGANVLYTDVWSSMGEENQKDE
KEKVFNGFTIDRDLVSKADKDAIILHCLPAYRSKEITDEIFESHKSRIFDQAENRLHAQQALLSCILQ
>Mature_308_residues
MLNPIKLASKNFLSSLDTSLEEFLHILELAKNFKNKDLSIKLQEKVLGLIFDKSSTRTRVSFQVAMSRLGGTTVDLNPTT
SQIGRGEPIRDTARVLSRYCDVLAIRTFKQTDLEEYAKWSSKPIINALTDLEHPCQALADFMTIKEEFLDFNDVVLTFIG
DGNNVANSLILCGALLGVEVRIACPKGYEPNSLLIDKAYEIYENKNLLKITNEPNTAVLGANVLYTDVWSSMGEENQKDE
KEKVFNGFTIDRDLVSKADKDAIILHCLPAYRSKEITDEIFESHKSRIFDQAENRLHAQQALLSCILQ

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=315, Percent_Identity=38.7301587301587, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI18105007, Length=312, Percent_Identity=29.8076923076923, Blast_Score=121, Evalue=9e-28,
Organism=Escherichia coli, GI1786469, Length=329, Percent_Identity=36.7781155015198, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1790703, Length=326, Percent_Identity=35.8895705521472, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI48994908, Length=350, Percent_Identity=23.1428571428571, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367364, Length=315, Percent_Identity=26.3492063492064, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=332, Percent_Identity=27.4096385542169, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322373, Length=314, Percent_Identity=35.3503184713376, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322331, Length=271, Percent_Identity=31.7343173431734, Blast_Score=122, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24642586, Length=295, Percent_Identity=31.1864406779661, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 34683; Mature: 34683

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNPIKLASKNFLSSLDTSLEEFLHILELAKNFKNKDLSIKLQEKVLGLIFDKSSTRTRV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCHHH
SFQVAMSRLGGTTVDLNPTTSQIGRGEPIRDTARVLSRYCDVLAIRTFKQTDLEEYAKWS
HHHHHHHHHCCCEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
SKPIINALTDLEHPCQALADFMTIKEEFLDFNDVVLTFIGDGNNVANSLILCGALLGVEV
CCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCEE
RIACPKGYEPNSLLIDKAYEIYENKNLLKITNEPNTAVLGANVLYTDVWSSMGEENQKDE
EEECCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHHHHHHCCCCCHHH
KEKVFNGFTIDRDLVSKADKDAIILHCLPAYRSKEITDEIFESHKSRIFDQAENRLHAQQ
HHHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLSCILQ
HHHHHHCC
>Mature Secondary Structure
MLNPIKLASKNFLSSLDTSLEEFLHILELAKNFKNKDLSIKLQEKVLGLIFDKSSTRTRV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCHHH
SFQVAMSRLGGTTVDLNPTTSQIGRGEPIRDTARVLSRYCDVLAIRTFKQTDLEEYAKWS
HHHHHHHHHCCCEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
SKPIINALTDLEHPCQALADFMTIKEEFLDFNDVVLTFIGDGNNVANSLILCGALLGVEV
CCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCEE
RIACPKGYEPNSLLIDKAYEIYENKNLLKITNEPNTAVLGANVLYTDVWSSMGEENQKDE
EEECCCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHHHHHHCCCCCHHH
KEKVFNGFTIDRDLVSKADKDAIILHCLPAYRSKEITDEIFESHKSRIFDQAENRLHAQQ
HHHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLSCILQ
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]