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The map label for this gene is lexA [H]

Identifier: 123968993

GI number: 123968993

Start: 1245800

End: 1246417

Strand: Reverse

Name: lexA [H]

Synonym: A9601_14611

Alternate gene names: 123968993

Gene position: 1246417-1245800 (Counterclockwise)

Preceding gene: 123968994

Following gene: 123968992

Centisome position: 74.64

GC content: 34.14

Gene sequence:

>618_bases
ATGGATGCTTCTTCAGGCGACCAGCTGACCCAAGCTCAGGATGAGCTTTATGAATGGATAAAGGAATATATGAAAAACTT
TCAACATAGTCCATCCATCAGACAAATGATGCAAGCTATGGGATTAAAATCTCCTGCTCCAATTCAAAGTCGTTTAAAAC
ATTTGCAAGAAAAGGGCTACATCTCTTGGCAAGAAGGTAAAGCAAGAACAATGCAAATTGTTGATGAAATTATAGAAGGT
GTACCAATTATGGGTTCAGTCGCAGCTGGAGGTTTAATTGAAACTTATTCTGATGTTCAAGAGAATTTAGATATTTCTGA
TGTTTTAAAAAAGAAAAATGTTTTTGCTCTTACAGTTAATGGTGATTCTATGATAGATGCATGTATTGCAGATGGAGATA
TGGTTTTGATGGAGCCAATTAAAGATTCATACTCTCTTAGAAACGGAATGATTGTTAGTGCATTGGTTCCAGGTTTAGGA
ACAACTTTAAAATATTTTGTTAAGAGAGGAGGAAAAATATTTCTTGAGGCAGCAAATCCAGCATATGAACCAATTGAGTT
GAATTTAGATGAAGTTATTTTTCAAGGAAAATTACTTGCTGTTTGGAGAAAAATATAA

Upstream 100 bases:

>100_bases
ATTACATGCTCAACAAGCTCTTTTATCTTGCATTCTCCAATAGAAATACTTGCGAACTAATTAAAAAAAAGGTACAAATG
TATTAGAGTACATATGTTTT

Downstream 100 bases:

>100_bases
TTCGTAATTTTTAATATTCTTAAGATAAAAAAATCAGATGCGAACTGAAATAATAATAAGACTTTTAACCTTTTTGATAT
ATTACTTAGGAAGTAATAGA

Product: SOS function regulatory protein, LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MDASSGDQLTQAQDELYEWIKEYMKNFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTMQIVDEIIEG
VPIMGSVAAGGLIETYSDVQENLDISDVLKKKNVFALTVNGDSMIDACIADGDMVLMEPIKDSYSLRNGMIVSALVPGLG
TTLKYFVKRGGKIFLEAANPAYEPIELNLDEVIFQGKLLAVWRKI

Sequences:

>Translated_205_residues
MDASSGDQLTQAQDELYEWIKEYMKNFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTMQIVDEIIEG
VPIMGSVAAGGLIETYSDVQENLDISDVLKKKNVFALTVNGDSMIDACIADGDMVLMEPIKDSYSLRNGMIVSALVPGLG
TTLKYFVKRGGKIFLEAANPAYEPIELNLDEVIFQGKLLAVWRKI
>Mature_205_residues
MDASSGDQLTQAQDELYEWIKEYMKNFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTMQIVDEIIEG
VPIMGSVAAGGLIETYSDVQENLDISDVLKKKNVFALTVNGDSMIDACIADGDMVLMEPIKDSYSLRNGMIVSALVPGLG
TTLKYFVKRGGKIFLEAANPAYEPIELNLDEVIFQGKLLAVWRKI

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=194, Percent_Identity=31.4432989690722, Blast_Score=91, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 22833; Mature: 22833

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASSGDQLTQAQDELYEWIKEYMKNFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGY
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
ISWQEGKARTMQIVDEIIEGVPIMGSVAAGGLIETYSDVQENLDISDVLKKKNVFALTVN
EEECCCHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHCCEEEEEEC
GDSMIDACIADGDMVLMEPIKDSYSLRNGMIVSALVPGLGTTLKYFVKRGGKIFLEAANP
CCHHHHHHHCCCCEEEECCCHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCEEEEEECCC
AYEPIELNLDEVIFQGKLLAVWRKI
CCCCEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDASSGDQLTQAQDELYEWIKEYMKNFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGY
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
ISWQEGKARTMQIVDEIIEGVPIMGSVAAGGLIETYSDVQENLDISDVLKKKNVFALTVN
EEECCCHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHCCEEEEEEC
GDSMIDACIADGDMVLMEPIKDSYSLRNGMIVSALVPGLGTTLKYFVKRGGKIFLEAANP
CCHHHHHHHCCCCEEEECCCHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCEEEEEECCC
AYEPIELNLDEVIFQGKLLAVWRKI
CCCCEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA