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The map label for this gene is lhgO [H]

Identifier: 123968951

GI number: 123968951

Start: 1190555

End: 1191757

Strand: Direct

Name: lhgO [H]

Synonym: A9601_14181

Alternate gene names: 123968951

Gene position: 1190555-1191757 (Clockwise)

Preceding gene: 123968934

Following gene: 123968952

Centisome position: 71.3

GC content: 30.42

Gene sequence:

>1203_bases
ATGATTCTGCAGAAAGAAAAAATAATAATAATTGGAGGAGGAATATTAGGATTATCTATTGCAAGAAAGTTTCTCAAAGA
GGGTTTTAAAAAAATTACAATTTTGGAGAAGGAAAAAGATATCGCAAATCACCAATCATCAAGAAATAGTGGTGTAATGC
ATGCTGGCCTTTATTATCCCCCAAACAGTTTAAAGGCAAAATTAAGTAGAGAAGGTATTCTTTTGATGAAGGATTACTGT
AATCAAAATTCAATTAAATGGGAAGAATGCGGAAAAGTTGTAGTAGCCACCAGTCAAAACGAATTAGAAAGATTAGATTC
CCTTTTTAACAATGGTAAAATAAATCAATTAATCGGCATTAAGAAATTAACTGCCAAAGAAGTAAATTTAATAGAGCCCT
ATGTTGAATCAAAAGCTGGTATTCATGTTCCAGAGGAAAGTATAGTTTCTTATAAGGAAGTTGCAAGAAAATATAAAGAA
GAAATCATTGCATTTGGCGGAAGGATACTCTGTTCCTCTAAAGTCGTAAATATTAATCACCATAATGAATATAAAGAGCT
AGTTTTACAAAATGGGGATAAATTATGTGGTGATATAATAATATCTACCGCTGGATTATATAGTGATAAGATTTCTAAAA
TTCTAGGAATTGATATTGAAAAAAAACAAATTTTACCCTTTAGAGGAGAATACTATTGCTTAAAACCTGATTATGAATAT
TTAGTTAAAAGCCTTATATATCCAGTTCCCAATCCAAAGTTACCCTTTTTGGGAGTACATTTTACTAAGATGATAAATGG
TGGTGTAGAAGCAGGACCTAATGCAATTTTAGCATTAGCAAGAGAAGGATATAAATGGAGTGATATCAATTTAAATGAAC
TTTATGAATCTATTTCATATATTGGTTTGCAAAGATTTATTTTAAAATATCCTCTTATTAGCGCTGGAGAAATAATTCGT
TCTTTGTCAAAAAATATTTTTCTTAAAAGTTTGCAAAAACTAATTCCAGACATAAAATCAGAAATGATTTATCGAGGCCC
TTCAGGAATAAGAGCTCAACTAATGAACCAAAAAGGAGATCTTGAACAAGATTTCGATATTAGAATCAAGGGAAACTTTA
TATCTATATTAAATGCACCAAGTCCTGCAGCAACTTCTTCACTCAGCATTGCAGATTATGTAGTAAGATCTCTAATTAGC
TGA

Upstream 100 bases:

>100_bases
TTTTTCATGTATTTTTACATATGGATATAATTTTTACTAAATCATACTATTTTAAATATTTAAGTAATATTTAAATTAAT
TAATATACCTCTAGCTAAAA

Downstream 100 bases:

>100_bases
ATTTATTATGAATAATTATTTAATAACAGGAAACTTGGGTTATATAGGGCCTGTTTTATGTAAATTTATAAAAAAAAATG
ATCCTAATTCATTCATAACC

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MILQKEKIIIIGGGILGLSIARKFLKEGFKKITILEKEKDIANHQSSRNSGVMHAGLYYPPNSLKAKLSREGILLMKDYC
NQNSIKWEECGKVVVATSQNELERLDSLFNNGKINQLIGIKKLTAKEVNLIEPYVESKAGIHVPEESIVSYKEVARKYKE
EIIAFGGRILCSSKVVNINHHNEYKELVLQNGDKLCGDIIISTAGLYSDKISKILGIDIEKKQILPFRGEYYCLKPDYEY
LVKSLIYPVPNPKLPFLGVHFTKMINGGVEAGPNAILALAREGYKWSDINLNELYESISYIGLQRFILKYPLISAGEIIR
SLSKNIFLKSLQKLIPDIKSEMIYRGPSGIRAQLMNQKGDLEQDFDIRIKGNFISILNAPSPAATSSLSIADYVVRSLIS

Sequences:

>Translated_400_residues
MILQKEKIIIIGGGILGLSIARKFLKEGFKKITILEKEKDIANHQSSRNSGVMHAGLYYPPNSLKAKLSREGILLMKDYC
NQNSIKWEECGKVVVATSQNELERLDSLFNNGKINQLIGIKKLTAKEVNLIEPYVESKAGIHVPEESIVSYKEVARKYKE
EIIAFGGRILCSSKVVNINHHNEYKELVLQNGDKLCGDIIISTAGLYSDKISKILGIDIEKKQILPFRGEYYCLKPDYEY
LVKSLIYPVPNPKLPFLGVHFTKMINGGVEAGPNAILALAREGYKWSDINLNELYESISYIGLQRFILKYPLISAGEIIR
SLSKNIFLKSLQKLIPDIKSEMIYRGPSGIRAQLMNQKGDLEQDFDIRIKGNFISILNAPSPAATSSLSIADYVVRSLIS
>Mature_400_residues
MILQKEKIIIIGGGILGLSIARKFLKEGFKKITILEKEKDIANHQSSRNSGVMHAGLYYPPNSLKAKLSREGILLMKDYC
NQNSIKWEECGKVVVATSQNELERLDSLFNNGKINQLIGIKKLTAKEVNLIEPYVESKAGIHVPEESIVSYKEVARKYKE
EIIAFGGRILCSSKVVNINHHNEYKELVLQNGDKLCGDIIISTAGLYSDKISKILGIDIEKKQILPFRGEYYCLKPDYEY
LVKSLIYPVPNPKLPFLGVHFTKMINGGVEAGPNAILALAREGYKWSDINLNELYESISYIGLQRFILKYPLISAGEIIR
SLSKNIFLKSLQKLIPDIKSEMIYRGPSGIRAQLMNQKGDLEQDFDIRIKGNFISILNAPSPAATSSLSIADYVVRSLIS

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=380, Percent_Identity=38.1578947368421, Blast_Score=270, Evalue=1e-72,
Organism=Escherichia coli, GI87082148, Length=367, Percent_Identity=38.6920980926431, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17565764, Length=408, Percent_Identity=38.4803921568627, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24585081, Length=377, Percent_Identity=38.7267904509284, Blast_Score=264, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 44856; Mature: 44856

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILQKEKIIIIGGGILGLSIARKFLKEGFKKITILEKEKDIANHQSSRNSGVMHAGLYYP
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCCCCCCCEEEEEEECC
PNSLKAKLSREGILLMKDYCNQNSIKWEECGKVVVATSQNELERLDSLFNNGKINQLIGI
CHHHHHHHCCCCEEEEHHHCCCCCEEHHHCCCEEEEECHHHHHHHHHHHCCCCHHHHHCH
KKLTAKEVNLIEPYVESKAGIHVPEESIVSYKEVARKYKEEIIAFGGRILCSSKVVNINH
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEECCC
HNEYKELVLQNGDKLCGDIIISTAGLYSDKISKILGIDIEKKQILPFRGEYYCLKPDYEY
CHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHH
LVKSLIYPVPNPKLPFLGVHFTKMINGGVEAGPNAILALAREGYKWSDINLNELYESISY
HHHHHHCCCCCCCCCEEHHHHHHHHCCCCCCCCHHEEHHHHCCCCCCCCCHHHHHHHHHH
IGLQRFILKYPLISAGEIIRSLSKNIFLKSLQKLIPDIKSEMIYRGPSGIRAQLMNQKGD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCC
LEQDFDIRIKGNFISILNAPSPAATSSLSIADYVVRSLIS
CCCCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MILQKEKIIIIGGGILGLSIARKFLKEGFKKITILEKEKDIANHQSSRNSGVMHAGLYYP
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCCCCCCCEEEEEEECC
PNSLKAKLSREGILLMKDYCNQNSIKWEECGKVVVATSQNELERLDSLFNNGKINQLIGI
CHHHHHHHCCCCEEEEHHHCCCCCEEHHHCCCEEEEECHHHHHHHHHHHCCCCHHHHHCH
KKLTAKEVNLIEPYVESKAGIHVPEESIVSYKEVARKYKEEIIAFGGRILCSSKVVNINH
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEECCC
HNEYKELVLQNGDKLCGDIIISTAGLYSDKISKILGIDIEKKQILPFRGEYYCLKPDYEY
CHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHH
LVKSLIYPVPNPKLPFLGVHFTKMINGGVEAGPNAILALAREGYKWSDINLNELYESISY
HHHHHHCCCCCCCCCEEHHHHHHHHCCCCCCCCHHEEHHHHCCCCCCCCCHHHHHHHHHH
IGLQRFILKYPLISAGEIIRSLSKNIFLKSLQKLIPDIKSEMIYRGPSGIRAQLMNQKGD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCC
LEQDFDIRIKGNFISILNAPSPAATSSLSIADYVVRSLIS
CCCCCEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]