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The map label for this gene is fcl [H]

Identifier: 123968933

GI number: 123968933

Start: 1169702

End: 1170670

Strand: Direct

Name: fcl [H]

Synonym: A9601_14001

Alternate gene names: 123968933

Gene position: 1169702-1170670 (Clockwise)

Preceding gene: 123968932

Following gene: 123968934

Centisome position: 70.05

GC content: 27.76

Gene sequence:

>969_bases
ATGAAAAAATTAATTACCAAAGAAGATAAAATATTTATTGCTGGTCATAAAGGAATGGTTGGTAGGTCAATTAAAAAAAA
TTTAATTTCTAAGAATTACACTAATTTAATTACTGTAGAAAAGAATGATTTAAATTTATTAGATGATTTAAAAGTAAAGA
ATTGGTTTAAAAAAAACAAACCTGATATTGTAATACTCGCGGCAGCAAAAGTTGGCGGGATTATGGCTAATAATAAATAC
CCTGCAAACTTTATTCTGGAAAATCTTAAAATTCAAACAAATGTTATAGAAGCATCTTGGGAAAATAATATAAAAAGATT
TTTATTTCTAGGAAGTAGTTGTATCTATCCAAAATACGCTAATCAGCCAATTAATGAAGAGGAATTATTAAACGGATATT
TAGAACCTACAAATCAATGGTATGCAATTGCAAAAATTGCAGGAATTAAATTATGTGAAGCACTAAGAAAGCAATATGAT
TTTGATGCCATAAGTTTAATGCCTACAAATTTATATGGACCAGGGGATAACTATGATCCAAACAATAGTCATGTACTTCC
ATCTCTAATAAGAAAATTTTATGAAGCCAAAATAAATAATTTGGATAAAGTAATTTGCTGGGGTACTGGTTATCCGATGA
GAGAGTTTCTGCATGTAGATGATCTTAGCGAAGCATCTATTTATGCTTTAGAAAATTGGTATCCTAAAAAAGAGGAGTTA
AAATATATGAATGTTGGAACTGGTAAGGATATAAGTATTAGAGAATTAGCAACTATAATCGCAAAAGAAATTGGTTTCGA
AGGGGAAATAGAATGGGATGTTTCTAAACCTGATGGAACGCCAAAAAAACAATTAAATATTTCAAAATTCAGCAAATTAG
GATGGTCCTCAAAAATAAAACTTTCAGATGGAATTAAAAATACAATTGATTGCTACATTAATGAAAATAAAAAAATAAAT
AATATTTAA

Upstream 100 bases:

>100_bases
GTTAGCAAAAAAAGAAGCTTTTTTATTTAGAAAAGGATTTAACATCCCTAAATCAATTGAAAACCCTCCGAGCATTTTTG
AAAAATAAATATACATTATA

Downstream 100 bases:

>100_bases
TTCTGAATTTTTTAAAAAATTGAAAATCTATGACTCTTAAATTACTTTGGTATTAGATCTTTAATACTTTATAATTATAA
AGATAAGTGCCACAACTCTA

Product: putative fucose synthetase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKKLITKEDKIFIAGHKGMVGRSIKKNLISKNYTNLITVEKNDLNLLDDLKVKNWFKKNKPDIVILAAAKVGGIMANNKY
PANFILENLKIQTNVIEASWENNIKRFLFLGSSCIYPKYANQPINEEELLNGYLEPTNQWYAIAKIAGIKLCEALRKQYD
FDAISLMPTNLYGPGDNYDPNNSHVLPSLIRKFYEAKINNLDKVICWGTGYPMREFLHVDDLSEASIYALENWYPKKEEL
KYMNVGTGKDISIRELATIIAKEIGFEGEIEWDVSKPDGTPKKQLNISKFSKLGWSSKIKLSDGIKNTIDCYINENKKIN
NI

Sequences:

>Translated_322_residues
MKKLITKEDKIFIAGHKGMVGRSIKKNLISKNYTNLITVEKNDLNLLDDLKVKNWFKKNKPDIVILAAAKVGGIMANNKY
PANFILENLKIQTNVIEASWENNIKRFLFLGSSCIYPKYANQPINEEELLNGYLEPTNQWYAIAKIAGIKLCEALRKQYD
FDAISLMPTNLYGPGDNYDPNNSHVLPSLIRKFYEAKINNLDKVICWGTGYPMREFLHVDDLSEASIYALENWYPKKEEL
KYMNVGTGKDISIRELATIIAKEIGFEGEIEWDVSKPDGTPKKQLNISKFSKLGWSSKIKLSDGIKNTIDCYINENKKIN
NI
>Mature_322_residues
MKKLITKEDKIFIAGHKGMVGRSIKKNLISKNYTNLITVEKNDLNLLDDLKVKNWFKKNKPDIVILAAAKVGGIMANNKY
PANFILENLKIQTNVIEASWENNIKRFLFLGSSCIYPKYANQPINEEELLNGYLEPTNQWYAIAKIAGIKLCEALRKQYD
FDAISLMPTNLYGPGDNYDPNNSHVLPSLIRKFYEAKINNLDKVICWGTGYPMREFLHVDDLSEASIYALENWYPKKEEL
KYMNVGTGKDISIRELATIIAKEIGFEGEIEWDVSKPDGTPKKQLNISKFSKLGWSSKIKLSDGIKNTIDCYINENKKIN
NI

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=284, Percent_Identity=31.6901408450704, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI7657641, Length=275, Percent_Identity=24.3636363636364, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788365, Length=315, Percent_Identity=50.7936507936508, Blast_Score=351, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17554428, Length=286, Percent_Identity=29.7202797202797, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922778, Length=292, Percent_Identity=29.4520547945205, Blast_Score=134, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 36783; Mature: 36783

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLITKEDKIFIAGHKGMVGRSIKKNLISKNYTNLITVEKNDLNLLDDLKVKNWFKKNK
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
PDIVILAAAKVGGIMANNKYPANFILENLKIQTNVIEASWENNIKRFLFLGSSCIYPKYA
CCEEEEEECCCCCEEECCCCCHHHHHHCEEEEEEEEECHHHCCCEEEEEECCCCCCCCCC
NQPINEEELLNGYLEPTNQWYAIAKIAGIKLCEALRKQYDFDAISLMPTNLYGPGDNYDP
CCCCCHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
NNSHVLPSLIRKFYEAKINNLDKVICWGTGYPMREFLHVDDLSEASIYALENWYPKKEEL
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCEEEEECCCCCCHHHE
KYMNVGTGKDISIRELATIIAKEIGFEGEIEWDVSKPDGTPKKQLNISKFSKLGWSSKIK
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCHHHHHHCCCCCEEE
LSDGIKNTIDCYINENKKINNI
ECCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKKLITKEDKIFIAGHKGMVGRSIKKNLISKNYTNLITVEKNDLNLLDDLKVKNWFKKNK
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
PDIVILAAAKVGGIMANNKYPANFILENLKIQTNVIEASWENNIKRFLFLGSSCIYPKYA
CCEEEEEECCCCCEEECCCCCHHHHHHCEEEEEEEEECHHHCCCEEEEEECCCCCCCCCC
NQPINEEELLNGYLEPTNQWYAIAKIAGIKLCEALRKQYDFDAISLMPTNLYGPGDNYDP
CCCCCHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
NNSHVLPSLIRKFYEAKINNLDKVICWGTGYPMREFLHVDDLSEASIYALENWYPKKEEL
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCEEEEECCCCCCHHHE
KYMNVGTGKDISIRELATIIAKEIGFEGEIEWDVSKPDGTPKKQLNISKFSKLGWSSKIK
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCHHHHHHCCCCCEEE
LSDGIKNTIDCYINENKKINNI
ECCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]