Click here to switch to the map view.

The map label for this gene is manC [H]

Identifier: 123968931

GI number: 123968931

Start: 1166741

End: 1168183

Strand: Direct

Name: manC [H]

Synonym: A9601_13981

Alternate gene names: 123968931

Gene position: 1166741-1168183 (Clockwise)

Preceding gene: 123968929

Following gene: 123968932

Centisome position: 69.87

GC content: 31.12

Gene sequence:

>1443_bases
ATGAATTCCAAAGTGATCATACCTGTTATTCTTTGTGGGGGATCTGGTTCGAGACTTTGGCCTTTATCAAGAAAAAGTCT
TCCTAAACAATTTTTATCTCTTAATCCAGAAAATAAAAAATCTTTACTTCAGCAAACTTATCAAAGAGTTAAAAATATAA
AAAATTGTTCTGGTCCAATAATTATTTGTAATGAAGAACATAGATTTATTGTCGCAGAACAAATGCGTGAAATAAAAATA
AAACCAACAGCGATAATATTAGAACCTTTCGGAAGAAATACTTGTCCTGCAATTACTTTGGCATGCCTTGAGGCAATTAA
ATATAGTAAAGATCCTTTTTTATTAATCTTATCTTCTGACCATATAGTACAATCTGAAAAAAAATTTCAAGAAGTTATCT
CTAAGGGAACAAATTATGCAGAACAAGGACGAATAGTTACATTTGGAATTATCCCAAAATCACCACAGACTGGTTTTGGT
TATATAGAGTCAGAGTACCCATTCAAAGAAAACTCATTAGATGGGCATAACATAATTAGATTTATAGAGAAGCCAGATTT
AAAAACTGCAAAGAAATTTATTAAAGATAGAAAATTCGTTTGGAATAGCGGTATTTTCTTATTCCAACCAAGTGTGATTT
TAAAAGAAATTCAGAAATTCAATCCTGAAATTATTAAATGCTGCAAAAAATCTCTTTCCAATAAGGAGATTGATCTAGAT
TTTACAAGAATTAACCAAGAAGAATTTTCAAAATGTCCTAATTTATCAATTGACTTTTCAATTATGGAAAAAACGGACTT
AGGAACTGTATTGCCTCTAGATGCGGGATGGGATGATATAGGAAGTTGGGAATCTCTTTGGCAAATATCAAAAAAAGATT
CTAAAGGGAATGTATTCCAGGGAAACGTTATCGGAGAAAAAACAGAAAATTGCTATTTGAGAAGTGAAAATAGGTTAATT
GTTGGGTTAGGGATAAAAGATCTAATAACAATCGAGACAAGAGATGCAATACTCGTTGCAGATAAACAAAAATCGCAAGA
TGTTAAAGATATTGTTAGTTTATTGAAAAAATCTAATATACCTGAAGGTCTTACACATAAAAAAGTTTATAGGCCTTGGG
GAAATTATTTATCATTAGTAGAAGATTCAAAATGGCAAGTTAAATTAATATCTGTTAATCCCGGAGAAAAACTTTCATTA
CAAAGACACAAGTTTAGAGCAGAACATTGGGTGGTAGTAGAGGGTGTCGCAAAAGTCGAAATTGACAAAAAAGTACTCAT
CTTAGAGGATAACCAGAGTACCTTTATACCTGTTGGAGCAAAACACAGATTGAGTAATTGCGGTAAAGAAATACTAAATA
TAATTGAGGTGCAAAGTGGTACATACTTAGGAGAAGATGACATAGAACGTTTTGAAGATAATTATGGGAGATTAAATTCT
TAA

Upstream 100 bases:

>100_bases
GCCCCAGTTATCAAGATGCGATTATTATTCAAAAAGGATTCTTTTCTGTTTAAATATTATAACTACTTTATTAATATAAT
AAATAATTATATATATATTT

Downstream 100 bases:

>100_bases
CTTTTTTAAAAAATTTTTTTAAATGAATTTTAATTTCTTGCTTATATTTGACTAGGCAATTAAGTATAATTTTCAAATAA
ATTTATGAAATATATCTCAC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MNSKVIIPVILCGGSGSRLWPLSRKSLPKQFLSLNPENKKSLLQQTYQRVKNIKNCSGPIIICNEEHRFIVAEQMREIKI
KPTAIILEPFGRNTCPAITLACLEAIKYSKDPFLLILSSDHIVQSEKKFQEVISKGTNYAEQGRIVTFGIIPKSPQTGFG
YIESEYPFKENSLDGHNIIRFIEKPDLKTAKKFIKDRKFVWNSGIFLFQPSVILKEIQKFNPEIIKCCKKSLSNKEIDLD
FTRINQEEFSKCPNLSIDFSIMEKTDLGTVLPLDAGWDDIGSWESLWQISKKDSKGNVFQGNVIGEKTENCYLRSENRLI
VGLGIKDLITIETRDAILVADKQKSQDVKDIVSLLKKSNIPEGLTHKKVYRPWGNYLSLVEDSKWQVKLISVNPGEKLSL
QRHKFRAEHWVVVEGVAKVEIDKKVLILEDNQSTFIPVGAKHRLSNCGKEILNIIEVQSGTYLGEDDIERFEDNYGRLNS

Sequences:

>Translated_480_residues
MNSKVIIPVILCGGSGSRLWPLSRKSLPKQFLSLNPENKKSLLQQTYQRVKNIKNCSGPIIICNEEHRFIVAEQMREIKI
KPTAIILEPFGRNTCPAITLACLEAIKYSKDPFLLILSSDHIVQSEKKFQEVISKGTNYAEQGRIVTFGIIPKSPQTGFG
YIESEYPFKENSLDGHNIIRFIEKPDLKTAKKFIKDRKFVWNSGIFLFQPSVILKEIQKFNPEIIKCCKKSLSNKEIDLD
FTRINQEEFSKCPNLSIDFSIMEKTDLGTVLPLDAGWDDIGSWESLWQISKKDSKGNVFQGNVIGEKTENCYLRSENRLI
VGLGIKDLITIETRDAILVADKQKSQDVKDIVSLLKKSNIPEGLTHKKVYRPWGNYLSLVEDSKWQVKLISVNPGEKLSL
QRHKFRAEHWVVVEGVAKVEIDKKVLILEDNQSTFIPVGAKHRLSNCGKEILNIIEVQSGTYLGEDDIERFEDNYGRLNS
>Mature_480_residues
MNSKVIIPVILCGGSGSRLWPLSRKSLPKQFLSLNPENKKSLLQQTYQRVKNIKNCSGPIIICNEEHRFIVAEQMREIKI
KPTAIILEPFGRNTCPAITLACLEAIKYSKDPFLLILSSDHIVQSEKKFQEVISKGTNYAEQGRIVTFGIIPKSPQTGFG
YIESEYPFKENSLDGHNIIRFIEKPDLKTAKKFIKDRKFVWNSGIFLFQPSVILKEIQKFNPEIIKCCKKSLSNKEIDLD
FTRINQEEFSKCPNLSIDFSIMEKTDLGTVLPLDAGWDDIGSWESLWQISKKDSKGNVFQGNVIGEKTENCYLRSENRLI
VGLGIKDLITIETRDAILVADKQKSQDVKDIVSLLKKSNIPEGLTHKKVYRPWGNYLSLVEDSKWQVKLISVNPGEKLSL
QRHKFRAEHWVVVEGVAKVEIDKKVLILEDNQSTFIPVGAKHRLSNCGKEILNIIEVQSGTYLGEDDIERFEDNYGRLNS

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=481, Percent_Identity=47.1933471933472, Blast_Score=478, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 54675; Mature: 54675

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKVIIPVILCGGSGSRLWPLSRKSLPKQFLSLNPENKKSLLQQTYQRVKNIKNCSGPI
CCCCEEEEEEEECCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCE
IICNEEHRFIVAEQMREIKIKPTAIILEPFGRNTCPAITLACLEAIKYSKDPFLLILSSD
EEECCCCCEEEEHHHHCEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
HIVQSEKKFQEVISKGTNYAEQGRIVTFGIIPKSPQTGFGYIESEYPFKENSLDGHNIIR
CHHHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCHHHHHH
FIEKPDLKTAKKFIKDRKFVWNSGIFLFQPSVILKEIQKFNPEIIKCCKKSLSNKEIDLD
HHCCCCHHHHHHHHHCCCEEEECCEEEEECHHHHHHHHHCCHHHHHHHHHHCCCCCEEEE
FTRINQEEFSKCPNLSIDFSIMEKTDLGTVLPLDAGWDDIGSWESLWQISKKDSKGNVFQ
HEECCHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEE
GNVIGEKTENCYLRSENRLIVGLGIKDLITIETRDAILVADKQKSQDVKDIVSLLKKSNI
CCCCCCCCCCCEEECCCEEEEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCC
PEGLTHKKVYRPWGNYLSLVEDSKWQVKLISVNPGEKLSLQRHKFRAEHWVVVEGVAKVE
CCCCCHHHHHCCHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHCCCCEEEEECEEEEE
IDKKVLILEDNQSTFIPVGAKHRLSNCGKEILNIIEVQSGTYLGEDDIERFEDNYGRLNS
ECCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNSKVIIPVILCGGSGSRLWPLSRKSLPKQFLSLNPENKKSLLQQTYQRVKNIKNCSGPI
CCCCEEEEEEEECCCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCE
IICNEEHRFIVAEQMREIKIKPTAIILEPFGRNTCPAITLACLEAIKYSKDPFLLILSSD
EEECCCCCEEEEHHHHCEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
HIVQSEKKFQEVISKGTNYAEQGRIVTFGIIPKSPQTGFGYIESEYPFKENSLDGHNIIR
CHHHHHHHHHHHHHCCCCHHHCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCHHHHHH
FIEKPDLKTAKKFIKDRKFVWNSGIFLFQPSVILKEIQKFNPEIIKCCKKSLSNKEIDLD
HHCCCCHHHHHHHHHCCCEEEECCEEEEECHHHHHHHHHCCHHHHHHHHHHCCCCCEEEE
FTRINQEEFSKCPNLSIDFSIMEKTDLGTVLPLDAGWDDIGSWESLWQISKKDSKGNVFQ
HEECCHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEE
GNVIGEKTENCYLRSENRLIVGLGIKDLITIETRDAILVADKQKSQDVKDIVSLLKKSNI
CCCCCCCCCCCEEECCCEEEEEECCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCC
PEGLTHKKVYRPWGNYLSLVEDSKWQVKLISVNPGEKLSLQRHKFRAEHWVVVEGVAKVE
CCCCCHHHHHCCHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHCCCCEEEEECEEEEE
IDKKVLILEDNQSTFIPVGAKHRLSNCGKEILNIIEVQSGTYLGEDDIERFEDNYGRLNS
ECCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]