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The map label for this gene is cobQ

Identifier: 123968870

GI number: 123968870

Start: 1111849

End: 1113336

Strand: Direct

Name: cobQ

Synonym: A9601_13371

Alternate gene names: 123968870

Gene position: 1111849-1113336 (Clockwise)

Preceding gene: 123968868

Following gene: 123968871

Centisome position: 66.58

GC content: 31.45

Gene sequence:

>1488_bases
ATGGTCTTAGGTACTTCCAGTGGAGCAGGGAAATCGTTAACGGTTACTGCTATTTGCAGGATTCTTAAAAATTTAGGAGA
AGAACCAATACCTTTTAAAGGACAAAATATGAGTAACAATGCTTGGGTTGATTGGGAAGGTGGAGAGATGGCATATTCAC
AAGCACTTCAAGCTTTTGCTTGTGGTATTAATCCCTCTGCAGAGATGAATCCCATTTTATTAAAACCACAAGGAAACTCA
ATAAGCGAGGTGATTCACCTTGGCAAAAGTATAGGAATAACAACTGCCTCAAATTACTACAAAGATTGGTTTATTCCAGG
TTGGGAAGTAATTAAAAAAAGTCTAAGTTCTATTTATGAAAAAACCCCAAATTGCCGTTTAATTATCGAAGGTGCTGGAA
GTCCAGTAGAAATGAATTTGATTCATAGAGATCTTACTAATTTAAGAGTTGCTAAGTATTTAAATGCAAATTGCATTTTA
GTTACTGATATTGAAAGAGGGGGTGTATTTGCCCAAATAATAGGAACGCTTGAATTAATGAAACCTGAAGAAAAAAAACT
TATTAAGGGGATAATTATAAATAGATTCAGAGGAGACCTTTCATTATTTGCAGAGGGGAAAAAATGGATAGAAAGTAAAA
CTCAAATTCCCATCATTGGAATTATTCCATGGCTAAATGACTCATTTCCTCCAGAAGATTCACTAGATTTATTAGAAAAA
AAATCTCGTCACACAACTGCCGAGATAAAAGTAGGAATTATAAAATTACCATCTATAAGCAATTTTTCAGATTTTGATCC
ATTAGAAAATGAAAAATCAATACTAATTGAATGGGTAAGAGAATCCCAAAACTTAAAAAAGTTCGATTTTATTATCCTTC
CTGGAAGTAAGCAAACTATTAAAGATCAAATTTATCTCAAAGAAAGTGGTTTATCTCAGGACATAAAAGAATACTCAAAC
AATAAAGGAAATATTATTGGTATTTGTGGAGGTTTACAAATGTTAGGGACATCACTTGAAGATCCTTTTTTCAAAGAGGG
GTCAAAAAGTTGTTTAGAACAAAAAATTAAAGGAATTGGATTACTGCCATTAAAAACCACTTTCTTTGAGAAAAAATTGA
CCAGACAAATCAGCTCCGAATCTTTATGGCCATGCCACTCAAAAATTAATGGATTCGAAATTCACAACGGCAAAACTGAA
TTAGTAGAAAGTGAAAACTTATTAAAGATTAGGCCTATTTTTAAGGATTTAGATCTTGGTTGGTATACTGAAAAAAAGGA
AGGTGGAACTATCGCAGGTACATACATTCACGGGATCTTTGAAAATGATAATTGGAGAGATCAATATATAAATTTAATAA
GGAAAAGTAAAAATTTACCAATATTCAATAAAAAATCAATATCTTATAAAAAGAAAAGAGAATCAATTATTGATAATCTT
GCCAACGAATTTGATAAACATCTAAATATCACATCATTACTAAATTGA

Upstream 100 bases:

>100_bases
TACCAAATTATAATTCAATTTAATAATTAATAAATTTTAAAATTAATATAAATTACTAATGGAGTTAGAAGCAAAATTAC
ATGAAATAAGGAAACCAATA

Downstream 100 bases:

>100_bases
AAGATAAAAAAATTAAAATTCTATGGGCAAATAATAACGAGACCTATGCTTCTGAGGGAGATGATTGGTTCTCAACTGCA
GAAAAAGCAGGTTTAGAAAT

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFACGINPSAEMNPILLKPQGNS
ISEVIHLGKSIGITTASNYYKDWFIPGWEVIKKSLSSIYEKTPNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLNANCIL
VTDIERGGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFAEGKKWIESKTQIPIIGIIPWLNDSFPPEDSLDLLEK
KSRHTTAEIKVGIIKLPSISNFSDFDPLENEKSILIEWVRESQNLKKFDFIILPGSKQTIKDQIYLKESGLSQDIKEYSN
NKGNIIGICGGLQMLGTSLEDPFFKEGSKSCLEQKIKGIGLLPLKTTFFEKKLTRQISSESLWPCHSKINGFEIHNGKTE
LVESENLLKIRPIFKDLDLGWYTEKKEGGTIAGTYIHGIFENDNWRDQYINLIRKSKNLPIFNKKSISYKKKRESIIDNL
ANEFDKHLNITSLLN

Sequences:

>Translated_495_residues
MVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFACGINPSAEMNPILLKPQGNS
ISEVIHLGKSIGITTASNYYKDWFIPGWEVIKKSLSSIYEKTPNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLNANCIL
VTDIERGGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFAEGKKWIESKTQIPIIGIIPWLNDSFPPEDSLDLLEK
KSRHTTAEIKVGIIKLPSISNFSDFDPLENEKSILIEWVRESQNLKKFDFIILPGSKQTIKDQIYLKESGLSQDIKEYSN
NKGNIIGICGGLQMLGTSLEDPFFKEGSKSCLEQKIKGIGLLPLKTTFFEKKLTRQISSESLWPCHSKINGFEIHNGKTE
LVESENLLKIRPIFKDLDLGWYTEKKEGGTIAGTYIHGIFENDNWRDQYINLIRKSKNLPIFNKKSISYKKKRESIIDNL
ANEFDKHLNITSLLN
>Mature_495_residues
MVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFACGINPSAEMNPILLKPQGNS
ISEVIHLGKSIGITTASNYYKDWFIPGWEVIKKSLSSIYEKTPNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLNANCIL
VTDIERGGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFAEGKKWIESKTQIPIIGIIPWLNDSFPPEDSLDLLEK
KSRHTTAEIKVGIIKLPSISNFSDFDPLENEKSILIEWVRESQNLKKFDFIILPGSKQTIKDQIYLKESGLSQDIKEYSN
NKGNIIGICGGLQMLGTSLEDPFFKEGSKSCLEQKIKGIGLLPLKTTFFEKKLTRQISSESLWPCHSKINGFEIHNGKTE
LVESENLLKIRPIFKDLDLGWYTEKKEGGTIAGTYIHGIFENDNWRDQYINLIRKSKNLPIFNKKSISYKKKRESIIDNL
ANEFDKHLNITSLLN

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_PROMS (A2BS60)

Other databases:

- EMBL:   CP000551
- RefSeq:   YP_001009728.1
- ProteinModelPortal:   A2BS60
- STRING:   A2BS60
- GeneID:   4718056
- GenomeReviews:   CP000551_GR
- KEGG:   pmb:A9601_13371
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- ProtClustDB:   PRK00784
- BioCyc:   PMAR146891:A9601_13371-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 55729; Mature: 55729

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 343-343 ACT_SITE 451-451

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFA
CEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
CGINPSAEMNPILLKPQGNSISEVIHLGKSIGITTASNYYKDWFIPGWEVIKKSLSSIYE
CCCCCCCCCCCEEEECCCCCHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHH
KTPNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLNANCILVTDIERGGVFAQIIGTLELM
CCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHC
KPEEKKLIKGIIINRFRGDLSLFAEGKKWIESKTQIPIIGIIPWLNDSFPPEDSLDLLEK
CCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHH
KSRHTTAEIKVGIIKLPSISNFSDFDPLENEKSILIEWVRESQNLKKFDFIILPGSKQTI
HCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCHHH
KDQIYLKESGLSQDIKEYSNNKGNIIGICGGLQMLGTSLEDPFFKEGSKSCLEQKIKGIG
HHEEEEECCCCHHHHHHHHCCCCCEEEEECCHHHHCCCCCCCHHHCCHHHHHHHHHHCCC
LLPLKTTFFEKKLTRQISSESLWPCHSKINGFEIHNGKTELVESENLLKIRPIFKDLDLG
CEECHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEECCCCCEECCCCCEEEECHHHHCCCC
WYTEKKEGGTIAGTYIHGIFENDNWRDQYINLIRKSKNLPIFNKKSISYKKKRESIIDNL
EEECCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHH
ANEFDKHLNITSLLN
HHHHHHCCCHHHHCC
>Mature Secondary Structure
MVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFA
CEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
CGINPSAEMNPILLKPQGNSISEVIHLGKSIGITTASNYYKDWFIPGWEVIKKSLSSIYE
CCCCCCCCCCCEEEECCCCCHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHH
KTPNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLNANCILVTDIERGGVFAQIIGTLELM
CCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHC
KPEEKKLIKGIIINRFRGDLSLFAEGKKWIESKTQIPIIGIIPWLNDSFPPEDSLDLLEK
CCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHH
KSRHTTAEIKVGIIKLPSISNFSDFDPLENEKSILIEWVRESQNLKKFDFIILPGSKQTI
HCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCHHH
KDQIYLKESGLSQDIKEYSNNKGNIIGICGGLQMLGTSLEDPFFKEGSKSCLEQKIKGIG
HHEEEEECCCCHHHHHHHHCCCCCEEEEECCHHHHCCCCCCCHHHCCHHHHHHHHHHCCC
LLPLKTTFFEKKLTRQISSESLWPCHSKINGFEIHNGKTELVESENLLKIRPIFKDLDLG
CEECHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEECCCCCEECCCCCEEEECHHHHCCCC
WYTEKKEGGTIAGTYIHGIFENDNWRDQYINLIRKSKNLPIFNKKSISYKKKRESIIDNL
EEECCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHH
ANEFDKHLNITSLLN
HHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA