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The map label for this gene is yciC [H]

Identifier: 123968668

GI number: 123968668

Start: 955323

End: 956672

Strand: Direct

Name: yciC [H]

Synonym: A9601_11351

Alternate gene names: 123968668

Gene position: 955323-956672 (Clockwise)

Preceding gene: 123968667

Following gene: 123968669

Centisome position: 57.21

GC content: 37.56

Gene sequence:

>1350_bases
ATGAGTATTAAGGAAAAGGTTCCTGTAACCATACTTACTGGATTCTTAGGATCAGGGAAGACTACTTTGCTTAATAGAAT
ATTGAGTGAAGAGCACGGGAAAAGAATAGCAGTAATTGAAAATGAATACGGTGAAGTGGGTATAGATCAAGGGCTCGTAA
TTAATGCAGATGAAGAAGTGTTTGAGATGTCAAACGGGTGCATTTGTTGTACTGTTCGCGGCGATTTAATAAGAGTCCTT
GGCAACCTTATGAAAAGAAGAGATAAGTTTGACTATGTTTTAGTAGAAACGACAGGATTAGCAGATCCAGGTCCAGTTGC
TCAGACATTTTTCATGGATGAAGAGATTAGTTCTGAATTCACTCTTGATGGAATTGTGACTTTAGTTGATGCTGCCCACA
TTGATCAACAGTTAGGCAGGAGTGATGAAAGTTCAGAACAAGTGGCATTTGCAGATGTTCTTGTCCTTAATAAAACTGAT
TTAGTCTCTGATGATGCACTAAATACTCTTGAATCGAGATTGAGAGACATGAACCGAATGACCCGAATTATTAGAGCCGA
GAATGCCAAAGTACCAATTGAAACAGTCTTAAATCTAAGTGCATTTGATCTTGATCAGATCCTTAAACGCAGGCCAACAT
TCCTTGAACCAGAATATCCTTTTGAATGGACAGGTGTTTACGATCTTGATGCAGGTAAATATGAATTAATGCTAGAAGAA
GGACCCGATCCAGAAATGTCCTTAGTAGCCCTCGCTAACCAAGGAGAGAGTGAAGAGGAACTTAAAGATGGTGCTGAATC
CTCCGTGAGACTTTATGCAGAAAAAGCTAATAGTTTAGATCCTGGAAATACCATCCCATATGGAGAACATATAAATCTCA
AATTGGAGGATAAAGGAAATAAATCATTCATCCTGAACATAGAAAAACCAACAAAAATAGGTTTGTTTACACAGCACACT
GCTGAAGAATTCAATATGAAAGTCATTAAAAGTGACGAAAATAAAGAGATTCCATTTAATACTGAAAGATTCTGGCAAGC
AGAGCACGAACATGATGATGAAGTAGGCTCAATTGCTATAGAGCGTTTTGGAGATGTTGACCCAGAAAAACTAAATACTT
GGATGGGAAGACTTCTATCAGAAAAAGGAGTGGATATATTCAGAACTAAAGGTTTCATAAGTTACTCAGGTAACCCAAGG
AGAATAGTTTTCCAGGGAGTTCACATGTTATTTACTGCACAACCTGATAAAGAATGGGGTAACGAACCTCGTAGAAATCA
ACTTGTTTTTATCGGTAGAAATTTAAATGAGAAAGAGATGCAAGAAGGCTTTGATAAATGCCTGAAATAG

Upstream 100 bases:

>100_bases
ATCACTTAATCAATAAAATTTTATAGATAAAAATGGTTTTCATTTCGATTTTTTGATTATTATATTGATGGTTAGCATTA
CATTTTAAAAACAGAGCGAA

Downstream 100 bases:

>100_bases
AACCATTTAGCCCAAGAGGCATGTTCCATGAAGGATGGACTGCTGAAGTTAACGATTACGCCATAGCATGTGGCTGGGCT
CTTAAAGGAAAACAATTTAT

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSIKEKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDDALNTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
GPDPEMSLVALANQGESEEELKDGAESSVRLYAEKANSLDPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKIGLFTQHT
AEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPR
RIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLK

Sequences:

>Translated_449_residues
MSIKEKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVL
GNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTD
LVSDDALNTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
GPDPEMSLVALANQGESEEELKDGAESSVRLYAEKANSLDPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKIGLFTQHT
AEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPR
RIVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLK
>Mature_448_residues
SIKEKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEVFEMSNGCICCTVRGDLIRVLG
NLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEFTLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDL
VSDDALNTLESRLRDMNRMTRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEEG
PDPEMSLVALANQGESEEELKDGAESSVRLYAEKANSLDPGNTIPYGEHINLKLEDKGNKSFILNIEKPTKIGLFTQHTA
EEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAIERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRR
IVFQGVHMLFTAQPDKEWGNEPRRNQLVFIGRNLNEKEMQEGFDKCLK

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=209, Percent_Identity=45.4545454545455, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI126722884, Length=209, Percent_Identity=45.4545454545455, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI146231952, Length=209, Percent_Identity=45.4545454545455, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI148727351, Length=209, Percent_Identity=44.9760765550239, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI223941779, Length=197, Percent_Identity=44.6700507614213, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI223941776, Length=198, Percent_Identity=43.9393939393939, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI119120938, Length=133, Percent_Identity=51.1278195488722, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI87082430, Length=213, Percent_Identity=39.4366197183099, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788499, Length=183, Percent_Identity=30.6010928961749, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=225, Percent_Identity=33.3333333333333, Blast_Score=143, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 50782; Mature: 50651

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKEKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHCCCE
TLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDDALNTLESRLRDMNRM
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
HHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEECEEEECCCCCEEEEEEC
GPDPEMSLVALANQGESEEELKDGAESSVRLYAEKANSLDPGNTIPYGEHINLKLEDKGN
CCCCCEEEEEEECCCCCHHHHHCCCCHHEEEEEHHCCCCCCCCCCCCCCEEEEEEECCCC
KSFILNIEKPTKIGLFTQHTAEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAI
CEEEEEECCCCEEEEEECCCHHHCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
ERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRRIVFQGVHMLFTAQPDKEWG
HHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCHHHC
NEPRRNQLVFIGRNLNEKEMQEGFDKCLK
CCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SIKEKVPVTILTGFLGSGKTTLLNRILSEEHGKRIAVIENEYGEVGIDQGLVINADEEV
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCCHHH
FEMSNGCICCTVRGDLIRVLGNLMKRRDKFDYVLVETTGLADPGPVAQTFFMDEEISSEF
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHEEECHHHCCCE
TLDGIVTLVDAAHIDQQLGRSDESSEQVAFADVLVLNKTDLVSDDALNTLESRLRDMNRM
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TRIIRAENAKVPIETVLNLSAFDLDQILKRRPTFLEPEYPFEWTGVYDLDAGKYELMLEE
HHHHHHCCCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCCEEECEEEECCCCCEEEEEEC
GPDPEMSLVALANQGESEEELKDGAESSVRLYAEKANSLDPGNTIPYGEHINLKLEDKGN
CCCCCEEEEEEECCCCCHHHHHCCCCHHEEEEEHHCCCCCCCCCCCCCCEEEEEEECCCC
KSFILNIEKPTKIGLFTQHTAEEFNMKVIKSDENKEIPFNTERFWQAEHEHDDEVGSIAI
CEEEEEECCCCEEEEEECCCHHHCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
ERFGDVDPEKLNTWMGRLLSEKGVDIFRTKGFISYSGNPRRIVFQGVHMLFTAQPDKEWG
HHHCCCCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCEEEEECEEEEEEECCCHHHC
NEPRRNQLVFIGRNLNEKEMQEGFDKCLK
CCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]