Click here to switch to the map view.

The map label for this gene is btuE [H]

Identifier: 123968628

GI number: 123968628

Start: 936467

End: 936946

Strand: Direct

Name: btuE [H]

Synonym: A9601_10951

Alternate gene names: 123968628

Gene position: 936467-936946 (Clockwise)

Preceding gene: 123968624

Following gene: 123968631

Centisome position: 56.08

GC content: 34.58

Gene sequence:

>480_bases
ATGCAAGTTGACGTACAAAATACTACAGTTCTTTCCGCAGACGGATCATCCATAAAACTAGGTGAATATTCAGGGGAGGT
AATTTTAGTTGTTAATGTAGCTAGTTATTGCGGAAATACTGCTCAGTATGATGATCTTCAAAAACTACATGATTTATATG
CAAGCAAAGGGCTAAGAATACTTGCTTTCCCTTGTAATGATTTTGGAAAACAAGAACCCGATTCTATCTCAGAAATAAAA
GATTTTTGCACAACAAAATATGGAGTTAAATTTGAAATCTATGAAAAAGTTCATGCCAAAGGGAATACCACAGAACCATA
CACAACCCTTAACAAAGTTGAACCTGAAGGAGATGTTGAATGGAATTTCGAGAAGTTTCTGATAGGGAAAGATAGTAAAG
TAATTGCAAGATTCAAGCCAGGTGTTAAACCGTTTGACGAAAACTTAATAGCAGCTATAGAAGTAGCTTTAGATTCATAA

Upstream 100 bases:

>100_bases
AAAAATTAAAACTTATGAAAGAAATAACCAAAAACACCATATAAATTAAACACAATAAAGTCTATACAATGCTATCTTCA
AAGGGTGATTTTTTTTAGAC

Downstream 100 bases:

>100_bases
AAACCTTCTTATTTTTCAAATTAAAATATTAAAAATTAAGACTTTTTTATTTAATTAAAAAATAAGCAAATTATTTTAAA
ATTTTCTTTTTTAGATTCAA

Product: glutathione peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MQVDVQNTTVLSADGSSIKLGEYSGEVILVVNVASYCGNTAQYDDLQKLHDLYASKGLRILAFPCNDFGKQEPDSISEIK
DFCTTKYGVKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVEWNFEKFLIGKDSKVIARFKPGVKPFDENLIAAIEVALDS

Sequences:

>Translated_159_residues
MQVDVQNTTVLSADGSSIKLGEYSGEVILVVNVASYCGNTAQYDDLQKLHDLYASKGLRILAFPCNDFGKQEPDSISEIK
DFCTTKYGVKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVEWNFEKFLIGKDSKVIARFKPGVKPFDENLIAAIEVALDS
>Mature_159_residues
MQVDVQNTTVLSADGSSIKLGEYSGEVILVVNVASYCGNTAQYDDLQKLHDLYASKGLRILAFPCNDFGKQEPDSISEIK
DFCTTKYGVKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVEWNFEKFLIGKDSKVIARFKPGVKPFDENLIAAIEVALDS

Specific function: Not essential for B12 transport; however, it is an auxiliary component of the transport system [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=139, Percent_Identity=44.6043165467626, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI90903240, Length=139, Percent_Identity=44.6043165467626, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI90903238, Length=120, Percent_Identity=45.8333333333333, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI15618997, Length=129, Percent_Identity=40.3100775193798, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI192455698, Length=132, Percent_Identity=37.1212121212121, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI6006001, Length=157, Percent_Identity=38.2165605095541, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI4557629, Length=145, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI33186887, Length=138, Percent_Identity=35.5072463768116, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI41406084, Length=157, Percent_Identity=32.484076433121, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI1788003, Length=181, Percent_Identity=38.6740331491713, Blast_Score=131, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17535473, Length=160, Percent_Identity=38.75, Blast_Score=115, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=38.5093167701863, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17506887, Length=147, Percent_Identity=38.7755102040816, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71993584, Length=138, Percent_Identity=38.4057971014493, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550320, Length=174, Percent_Identity=32.7586206896552, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193209493, Length=175, Percent_Identity=32.5714285714286, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71993573, Length=86, Percent_Identity=41.8604651162791, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI193210709, Length=64, Percent_Identity=50, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=135, Percent_Identity=43.7037037037037, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322228, Length=135, Percent_Identity=41.4814814814815, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322826, Length=154, Percent_Identity=37.012987012987, Blast_Score=109, Evalue=2e-25,
Organism=Drosophila melanogaster, GI85726443, Length=146, Percent_Identity=34.9315068493151, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24656772, Length=148, Percent_Identity=35.8108108108108, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656767, Length=145, Percent_Identity=36.551724137931, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24656777, Length=145, Percent_Identity=36.551724137931, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: 1.11.1.9

Molecular weight: Translated: 17666; Mature: 17666

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVDVQNTTVLSADGSSIKLGEYSGEVILVVNVASYCGNTAQYDDLQKLHDLYASKGLRI
CEEECCCCEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEE
LAFPCNDFGKQEPDSISEIKDFCTTKYGVKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVE
EEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCE
WNFEKFLIGKDSKVIARFKPGVKPFDENLIAAIEVALDS
ECCEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MQVDVQNTTVLSADGSSIKLGEYSGEVILVVNVASYCGNTAQYDDLQKLHDLYASKGLRI
CEEECCCCEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEE
LAFPCNDFGKQEPDSISEIKDFCTTKYGVKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVE
EEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCE
WNFEKFLIGKDSKVIARFKPGVKPFDENLIAAIEVALDS
ECCEEEEECCCCEEEEEECCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3528129; 9097039; 9278503 [H]