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The map label for this gene is ahpC [C]

Identifier: 123968546

GI number: 123968546

Start: 875313

End: 875897

Strand: Direct

Name: ahpC [C]

Synonym: A9601_10131

Alternate gene names: 123968546

Gene position: 875313-875897 (Clockwise)

Preceding gene: 123968544

Following gene: 123968549

Centisome position: 52.42

GC content: 39.32

Gene sequence:

>585_bases
ATGAGCTTAAGAGTTGGCCAAGAAGCACCAGACTTTAGTGCTACAGCAGTATATGATCAAGAGTTTAAGGAGGTTACACT
TTCAGGTCTAAGAGGTAAATGGGTTGTTTTATTCTTCTACCCACTAGATTTTACATTTGTATGTCCAACTGAAATTACTG
CATTTAGTGATAGATACCAAGATTTCTCAGCTCTTAATACTGAAATACTTGGAGTGTCAGTTGATAGCAAACACTGTCAT
TTGGCTTGGATACAAACCCCAAGAAATGAAGGCGGAATAGGTGATATTAACTACCCATTAGTTTCTGACTTAAAAAGAGA
AATTTGCCAGGCTTACAATGTTCTTAATGATGATGGAGAGGCCGATAGAGGTTTATTTCTTATCAATCCCGAAGGAGTAG
TTATGCATACGACTGTTAACAAGGCTCCTGTAGGTAGAAATGTCGATGAAACGCTAAGGATTCTTCAAGGCTATCAATAC
GTTGCGGCAAACCCCGATGAAGTATGTCCAGCAAACTGGACCCCTGGGGAGAAAACAATGTTAGAGGACCCAAAAGGTAG
TAAGGAATATTTTTCTGCGCTATAA

Upstream 100 bases:

>100_bases
TGAATTAAAAAAAAACTTGCTAATTCATTATCAATAAAATTATAATACTTACTACGGTCATTAAGACCATACATAATTTA
AATTAAGGACAAATTTTTTC

Downstream 100 bases:

>100_bases
GAAAATTAAAAACATTTAAGTAAGTAATGAGTAGTAAATAATTATAAAAAAATAAAAAATAAATATATTCAAAAAGGGGA
TAACATCCCCTTTTTGAGGT

Product: thioredoxin peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSLRVGQEAPDFSATAVYDQEFKEVTLSGLRGKWVVLFFYPLDFTFVCPTEITAFSDRYQDFSALNTEILGVSVDSKHCH
LAWIQTPRNEGGIGDINYPLVSDLKREICQAYNVLNDDGEADRGLFLINPEGVVMHTTVNKAPVGRNVDETLRILQGYQY
VAANPDEVCPANWTPGEKTMLEDPKGSKEYFSAL

Sequences:

>Translated_194_residues
MSLRVGQEAPDFSATAVYDQEFKEVTLSGLRGKWVVLFFYPLDFTFVCPTEITAFSDRYQDFSALNTEILGVSVDSKHCH
LAWIQTPRNEGGIGDINYPLVSDLKREICQAYNVLNDDGEADRGLFLINPEGVVMHTTVNKAPVGRNVDETLRILQGYQY
VAANPDEVCPANWTPGEKTMLEDPKGSKEYFSAL
>Mature_193_residues
SLRVGQEAPDFSATAVYDQEFKEVTLSGLRGKWVVLFFYPLDFTFVCPTEITAFSDRYQDFSALNTEILGVSVDSKHCHL
AWIQTPRNEGGIGDINYPLVSDLKREICQAYNVLNDDGEADRGLFLINPEGVVMHTTVNKAPVGRNVDETLRILQGYQYV
AANPDEVCPANWTPGEKTMLEDPKGSKEYFSAL

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=190, Percent_Identity=58.9473684210526, Blast_Score=228, Evalue=3e-60,
Organism=Homo sapiens, GI4505591, Length=191, Percent_Identity=56.020942408377, Blast_Score=225, Evalue=2e-59,
Organism=Homo sapiens, GI32455266, Length=191, Percent_Identity=56.020942408377, Blast_Score=225, Evalue=2e-59,
Organism=Homo sapiens, GI32455264, Length=191, Percent_Identity=56.020942408377, Blast_Score=225, Evalue=2e-59,
Organism=Homo sapiens, GI5802974, Length=188, Percent_Identity=55.3191489361702, Blast_Score=218, Evalue=3e-57,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=52.6041666666667, Blast_Score=216, Evalue=8e-57,
Organism=Homo sapiens, GI32483377, Length=186, Percent_Identity=54.8387096774194, Blast_Score=215, Evalue=2e-56,
Organism=Homo sapiens, GI33188454, Length=88, Percent_Identity=67.0454545454545, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=28.4210526315789, Blast_Score=78, Evalue=6e-15,
Organism=Escherichia coli, GI1786822, Length=181, Percent_Identity=36.4640883977901, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32565831, Length=188, Percent_Identity=53.7234042553192, Blast_Score=210, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI193204376, Length=188, Percent_Identity=53.7234042553192, Blast_Score=209, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=48.9247311827957, Blast_Score=195, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25153706, Length=200, Percent_Identity=26, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=194, Percent_Identity=48.4536082474227, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320661, Length=193, Percent_Identity=46.1139896373057, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319407, Length=189, Percent_Identity=29.1005291005291, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24656348, Length=189, Percent_Identity=52.3809523809524, Blast_Score=209, Evalue=9e-55,
Organism=Drosophila melanogaster, GI17864676, Length=189, Percent_Identity=52.3809523809524, Blast_Score=209, Evalue=9e-55,
Organism=Drosophila melanogaster, GI17738015, Length=194, Percent_Identity=52.0618556701031, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17157991, Length=189, Percent_Identity=50.7936507936508, Blast_Score=203, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24641739, Length=189, Percent_Identity=50.7936507936508, Blast_Score=203, Evalue=5e-53,
Organism=Drosophila melanogaster, GI21357347, Length=191, Percent_Identity=46.0732984293194, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=32.8042328042328, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=32.8042328042328, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=32.8042328042328, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581278, Length=187, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21693; Mature: 21561

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRVGQEAPDFSATAVYDQEFKEVTLSGLRGKWVVLFFYPLDFTFVCPTEITAFSDRYQ
CCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHH
DFSALNTEILGVSVDSKHCHLAWIQTPRNEGGIGDINYPLVSDLKREICQAYNVLNDDGE
HHHHCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
ADRGLFLINPEGVVMHTTVNKAPVGRNVDETLRILQGYQYVAANPDEVCPANWTPGEKTM
CCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCC
LEDPKGSKEYFSAL
CCCCCCCHHHHHCC
>Mature Secondary Structure 
SLRVGQEAPDFSATAVYDQEFKEVTLSGLRGKWVVLFFYPLDFTFVCPTEITAFSDRYQ
CCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCHHHHHHHHHH
DFSALNTEILGVSVDSKHCHLAWIQTPRNEGGIGDINYPLVSDLKREICQAYNVLNDDGE
HHHHCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
ADRGLFLINPEGVVMHTTVNKAPVGRNVDETLRILQGYQYVAANPDEVCPANWTPGEKTM
CCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCC
LEDPKGSKEYFSAL
CCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]