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The map label for this gene is ilvA [H]

Identifier: 123968486

GI number: 123968486

Start: 820171

End: 821712

Strand: Reverse

Name: ilvA [H]

Synonym: A9601_09531

Alternate gene names: 123968486

Gene position: 821712-820171 (Counterclockwise)

Preceding gene: 123968488

Following gene: 123968485

Centisome position: 49.21

GC content: 32.3

Gene sequence:

>1542_bases
ATGAATGATTATTTTGAAAAAATACTTCAAGCTGAAGTCTATGAAGTTGCAAAAAAAACACCACTAGAGAAAGCTCATAA
TTTAAGTAACACACTTAATAATGAAGTTTTTCTAAAAAGAGAAGATCTTCAGGATGTATTTTCATTCAAAATAAGAGGTG
CATATAACAAAATGAGTAAGCTAACTAATTCACAGCTTGCTCAGGGAGTAATTACTTCTAGTGCTGGAAATCATGCCCAA
GGGGTTGCACTTAGTGCCCTTAAGTTAAATTGCCAAGCAACCATATTAATGCCCGTTACCACACCTATAGTAAAAGTTAA
TGCAGTAAAAAGTTTAAAAGCAAAAGTTATATTATATGGTGACAACTATGATGAAACATACAAAGAGGCAATAAGGATTA
GCCAAGAAAGAAATTTATGCTTTATTCATCCCTTTGATGATCCAGAAGTAATAGCAGGACAAGGAACTATAGCTATAGAA
CTTGAACAGCAGCTTAAGGAAAAACCTTATGCAATTTATATTGCTGTAGGTGGTGGGGGATTGATATCAGGAATATCCAT
ATACGTTAAAAAAATATGGCCAGAAGTAAAAATAATTGGTGTAGAACCTGAAGATGCTGACGCTATGACTAAATCATTGG
AAGAAGAAAAAATTGTGGAACTACCTTCTGTAGGTCAATTTGCAGATGGAGTAGCGGTAAAAAAAATTGGTAAAAATACT
TTTGATATTGGTAGAAAATATATAGATAAGATGATTAGGGTTAATACTGACGAAATCTGTGCTGCTATAAAAGATGTTTT
TGAGGATACTAGATCCATATTAGAGCCCGCAGGGGCCTTATCAATAGCGGGAATGAAAAAAGATATTTTAAATTCGAATC
ATTCAAATAGAAAAATGGTTGCGATTGCATGTGGTGCAAATATGAATTTTGAGAGGCTTAGATTTGTAGCAGAAAGAGCA
GAACTTGGAGAGTGCAAAGAAGTAATGATGGCTGTTGAAATTCCTGAACGTGCTGGTAGTCTAATTGATTTTTGTAAGTT
ACTTGATAATAGAAATCTAACAGAATTTAGCTATAGGATGTCGAATTCTAAGAATGCACAGATATTTGTAGGGGTTCAAG
TCTATGGTTTAAATGATAAAAAAAATTTATTAAATGTATTTAGAAATTCTGAGTACTCATTTATTGACATAAGTGATGAT
GAATTATCTAAAAATCATCTCAGACATATGGTAGGTGGAAGATTACCAAGGGATTTTAAAGAGATGGAATATAAAAACTT
TATTGAGCTTTTATACAGATTTGAGTTTCCTGAAAGGCCTGGCGCATTAATAAACTTCTTAAATAATATGAAATCTAATT
GGTCTATAAGCGTATTTCACTACAGGAATTATGGAGCTGATGTAGGGAAAATTGTCATTGGAGTTTTGATCGATAAAAAT
GAGATTTTAGAGTGGAATAAATTTGTAAAAATTCTAGGTTATAAATTCTGGGATGAAACTCAAAACGATACATATAGATT
GTTCCTTGGTGCATCAGATTAA

Upstream 100 bases:

>100_bases
TCTATATAATCTAAAACGCCGAGGTGCAAAATGAGTATTTTTTTTGAAATAGATCATGTAATGTTTTATTAGATTAATAA
TTAATGCTAAAAATATATAT

Downstream 100 bases:

>100_bases
ATTTAAGGTAAATTAGGAAAGATTTCGGTAATTAAAATCAATCAATCTGATCTAAATACCACGCCAATATCTGATATAGA
TCTAGTTACTAAAGTTGAAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MNDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSKLTNSQLAQGVITSSAGNHAQ
GVALSALKLNCQATILMPVTTPIVKVNAVKSLKAKVILYGDNYDETYKEAIRISQERNLCFIHPFDDPEVIAGQGTIAIE
LEQQLKEKPYAIYIAVGGGGLISGISIYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELPSVGQFADGVAVKKIGKNT
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNRKMVAIACGANMNFERLRFVAERA
ELGECKEVMMAVEIPERAGSLIDFCKLLDNRNLTEFSYRMSNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDD
ELSKNHLRHMVGGRLPRDFKEMEYKNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
EILEWNKFVKILGYKFWDETQNDTYRLFLGASD

Sequences:

>Translated_513_residues
MNDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSKLTNSQLAQGVITSSAGNHAQ
GVALSALKLNCQATILMPVTTPIVKVNAVKSLKAKVILYGDNYDETYKEAIRISQERNLCFIHPFDDPEVIAGQGTIAIE
LEQQLKEKPYAIYIAVGGGGLISGISIYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELPSVGQFADGVAVKKIGKNT
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNRKMVAIACGANMNFERLRFVAERA
ELGECKEVMMAVEIPERAGSLIDFCKLLDNRNLTEFSYRMSNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDD
ELSKNHLRHMVGGRLPRDFKEMEYKNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
EILEWNKFVKILGYKFWDETQNDTYRLFLGASD
>Mature_513_residues
MNDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSKLTNSQLAQGVITSSAGNHAQ
GVALSALKLNCQATILMPVTTPIVKVNAVKSLKAKVILYGDNYDETYKEAIRISQERNLCFIHPFDDPEVIAGQGTIAIE
LEQQLKEKPYAIYIAVGGGGLISGISIYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELPSVGQFADGVAVKKIGKNT
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNRKMVAIACGANMNFERLRFVAERA
ELGECKEVMMAVEIPERAGSLIDFCKLLDNRNLTEFSYRMSNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDD
ELSKNHLRHMVGGRLPRDFKEMEYKNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
EILEWNKFVKILGYKFWDETQNDTYRLFLGASD

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=273, Percent_Identity=35.5311355311355, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=29.903536977492, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI19923959, Length=313, Percent_Identity=28.1150159744409, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1790207, Length=510, Percent_Identity=46.8627450980392, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789505, Length=295, Percent_Identity=38.3050847457627, Blast_Score=179, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71991565, Length=327, Percent_Identity=31.4984709480122, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=330, Percent_Identity=31.8181818181818, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17508781, Length=294, Percent_Identity=27.891156462585, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=524, Percent_Identity=46.3740458015267, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322631, Length=302, Percent_Identity=34.7682119205298, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6319788, Length=327, Percent_Identity=28.1345565749235, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322024, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355833, Length=331, Percent_Identity=35.9516616314199, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=34.9206349206349, Blast_Score=125, Evalue=9e-29,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 58051; Mature: 58051

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHH
LTNSQLAQGVITSSAGNHAQGVALSALKLNCQATILMPVTTPIVKVNAVKSLKAKVILYG
HHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEEEEHHHCCEEEEEEEE
DNYDETYKEAIRISQERNLCFIHPFDDPEVIAGQGTIAIELEQQLKEKPYAIYIAVGGGG
CCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEHHHHHCCCEEEEEEECCCC
LISGISIYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELPSVGQFADGVAVKKIGKNT
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHCCCCCCCCHHCCHHHHHHCCCH
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNRKMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCEEE
AIACGANMNFERLRFVAERAELGECKEVMMAVEIPERAGSLIDFCKLLDNRNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCHHHEEC
SNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDDELSKNHLRHMVGGRLPRDFK
CCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHH
EMEYKNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEEECCH
EILEWNKFVKILGYKFWDETQNDTYRLFLGASD
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MNDYFEKILQAEVYEVAKKTPLEKAHNLSNTLNNEVFLKREDLQDVFSFKIRGAYNKMSK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHH
LTNSQLAQGVITSSAGNHAQGVALSALKLNCQATILMPVTTPIVKVNAVKSLKAKVILYG
HHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEEEECCCCEEEEEHHHCCEEEEEEEE
DNYDETYKEAIRISQERNLCFIHPFDDPEVIAGQGTIAIELEQQLKEKPYAIYIAVGGGG
CCCCHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEEHHHHHCCCEEEEEEECCCC
LISGISIYVKKIWPEVKIIGVEPEDADAMTKSLEEEKIVELPSVGQFADGVAVKKIGKNT
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHCCCCCCCCHHCCHHHHHHCCCH
FDIGRKYIDKMIRVNTDEICAAIKDVFEDTRSILEPAGALSIAGMKKDILNSNHSNRKMV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCEEE
AIACGANMNFERLRFVAERAELGECKEVMMAVEIPERAGSLIDFCKLLDNRNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCHHHEEC
SNSKNAQIFVGVQVYGLNDKKNLLNVFRNSEYSFIDISDDELSKNHLRHMVGGRLPRDFK
CCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHH
EMEYKNFIELLYRFEFPERPGALINFLNNMKSNWSISVFHYRNYGADVGKIVIGVLIDKN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCHHHEEEEEEECCH
EILEWNKFVKILGYKFWDETQNDTYRLFLGASD
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA