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The map label for this gene is msrA [H]

Identifier: 123968438

GI number: 123968438

Start: 777096

End: 777824

Strand: Reverse

Name: msrA [H]

Synonym: A9601_09051

Alternate gene names: 123968438

Gene position: 777824-777096 (Counterclockwise)

Preceding gene: 123968439

Following gene: 123968436

Centisome position: 46.58

GC content: 30.73

Gene sequence:

>729_bases
ATGTTTAAATTCTTGAAAAACATCATGAATAATGAGGAGGTAAATTTAACTAATGATGCTTATTCATTACATAGAATATT
AAAAACAGATATCAAAAAAGATCCTAACTTAGAAGAAGATGAAATAATTTTTGGATGTGGTTGTTTCTGGGGTGCTGAAA
AATGTTTTTGGAAACTTCCTGGAGTTATCACAACTTCTGTAGGTTATGCTGGAGGAGAAAAAAACAATCCAACTTATTAT
GAAGTATGTTCCGGCTTAACTGGTCATTCAGAAGTTGTAAGAGTTATATGGGATAAAAGGCAAATTGATTTAAGTGACTT
ATTAAAAATGTTTTGGGAATGTCATGACCCTACTCAAAAAAACAGACAAGGTAATGATATGGGAACACAATATAGATCAG
CAATATATTACAAAAATGAAAATAATATTCCAATCATATTAGCCAGTAAGGAACAATATCAAACGGAACTAAGCAAAAAG
AATTTTGGTTTAATTGAAACGGAAATAAAAATGATTGATTCATATTTTTATGCTGAACAGTACCATCAACAATATCTTGC
ATCAGCTGGAAGCAGGCAGTATTGTTCCGCTTCACCTACAAAAGTTAAGTTAGGAGTTTTTTCTGGAAGCAACTATAAAT
TAGAGGATCATATATGGGAAAACTTTAATTGGGAAGTTGACAAGTGTGTATTGAGATCTGATAACAATCCCATAAAGAAT
AACATTTAA

Upstream 100 bases:

>100_bases
GTAAATGGACTATATAAACAACTTTGGGATAGAGAACTAGCCACCAGAATTGTTAAGAGCTAAAAGTAATTTTTTTTCTT
ATAATAAATAGATTTAAATT

Downstream 100 bases:

>100_bases
ATCAATCTAATCTTTATAGTAAAGACACGGGGCGTAGCGCAGTTTGGTAGCGCACCACTTTGGGGTAGTGGGGGTCGTGG
GTTCAAATCCCGCCGTTCCG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MFKFLKNIMNNEEVNLTNDAYSLHRILKTDIKKDPNLEEDEIIFGCGCFWGAEKCFWKLPGVITTSVGYAGGEKNNPTYY
EVCSGLTGHSEVVRVIWDKRQIDLSDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYYKNENNIPIILASKEQYQTELSKK
NFGLIETEIKMIDSYFYAEQYHQQYLASAGSRQYCSASPTKVKLGVFSGSNYKLEDHIWENFNWEVDKCVLRSDNNPIKN
NI

Sequences:

>Translated_242_residues
MFKFLKNIMNNEEVNLTNDAYSLHRILKTDIKKDPNLEEDEIIFGCGCFWGAEKCFWKLPGVITTSVGYAGGEKNNPTYY
EVCSGLTGHSEVVRVIWDKRQIDLSDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYYKNENNIPIILASKEQYQTELSKK
NFGLIETEIKMIDSYFYAEQYHQQYLASAGSRQYCSASPTKVKLGVFSGSNYKLEDHIWENFNWEVDKCVLRSDNNPIKN
NI
>Mature_242_residues
MFKFLKNIMNNEEVNLTNDAYSLHRILKTDIKKDPNLEEDEIIFGCGCFWGAEKCFWKLPGVITTSVGYAGGEKNNPTYY
EVCSGLTGHSEVVRVIWDKRQIDLSDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYYKNENNIPIILASKEQYQTELSKK
NFGLIETEIKMIDSYFYAEQYHQQYLASAGSRQYCSASPTKVKLGVFSGSNYKLEDHIWENFNWEVDKCVLRSDNNPIKN
NI

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=164, Percent_Identity=54.2682926829268, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI208609995, Length=164, Percent_Identity=54.2682926829268, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI208609993, Length=120, Percent_Identity=50.8333333333333, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1790665, Length=145, Percent_Identity=52.4137931034483, Blast_Score=159, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=36.6197183098592, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=172, Percent_Identity=36.046511627907, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24664627, Length=157, Percent_Identity=34.3949044585987, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24664631, Length=157, Percent_Identity=33.7579617834395, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=35.2517985611511, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 28099; Mature: 28099

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFLKNIMNNEEVNLTNDAYSLHRILKTDIKKDPNLEEDEIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHCCHHHHHHCC
GVITTSVGYAGGEKNNPTYYEVCSGLTGHSEVVRVIWDKRQIDLSDLLKMFWECHDPTQK
CEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSAIYYKNENNIPIILASKEQYQTELSKKNFGLIETEIKMIDSYFYAEQ
CCCCCHHHHHHHHEEEEECCCCEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YHQQYLASAGSRQYCSASPTKVKLGVFSGSNYKLEDHIWENFNWEVDKCVLRSDNNPIKN
HHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEHHHHHCCCCCCHHEEEEECCCCCCCC
NI
CC
>Mature Secondary Structure
MFKFLKNIMNNEEVNLTNDAYSLHRILKTDIKKDPNLEEDEIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHCCHHHHHHCC
GVITTSVGYAGGEKNNPTYYEVCSGLTGHSEVVRVIWDKRQIDLSDLLKMFWECHDPTQK
CEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSAIYYKNENNIPIILASKEQYQTELSKKNFGLIETEIKMIDSYFYAEQ
CCCCCHHHHHHHHEEEEECCCCEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YHQQYLASAGSRQYCSASPTKVKLGVFSGSNYKLEDHIWENFNWEVDKCVLRSDNNPIKN
HHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEHHHHHCCCCCCHHEEEEECCCCCCCC
NI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA