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The map label for this gene is hemA [H]

Identifier: 123968363

GI number: 123968363

Start: 719020

End: 720330

Strand: Direct

Name: hemA [H]

Synonym: A9601_08301

Alternate gene names: 123968363

Gene position: 719020-720330 (Clockwise)

Preceding gene: 123968362

Following gene: 123968364

Centisome position: 43.06

GC content: 33.49

Gene sequence:

>1311_bases
ATGCATATTGTTGTCGTCGGACTGAGTCATCGCACGGCACCTGTTGAAGTGCGTGAGAAATTAAGTATTCCTGACCAATC
CATAACAGAATCATTGAAAGCATTAAAAGCTTTCTCTGATGTATTAGAGGTGTCAATCTTAAGTACTTGTAATAGGATGG
AAATATATGCACTAGTAAAGGATAAAAATACTGGAATTTCATCTATAAAGGAATTTATATCAGAATATTCTGGAATTATT
TTTGAAGATTTAAATCCACATCTTTTTTGCTTTAGACAGGAAGAAGCAGTTTTGCATTTGATGAAAGTCTCGGCAGGACT
CGATAGCCTCGTTTTAGGTGAAGGACAAATCCTTTCGCAGGTAAAAAAAATGATGAGGTTAGGTCAAGAAAATCAATCTA
CTGGCCCAATTCTTAATAGATTATTAACACAATCAGTTAGTACAGGTAAAAAAGTAAGATCTGAAACAAATTTAGGAACT
GGAGCCGTATCAATTAGTTCAGCAGCTGTAGAACTTGCCCAATTAAAAATTGGACAAGAAAAGGGTTTTGATACTCTCGT
AAGTTTGGAATCAGAGAACGTTCTTGTTGTTGGCGCTGGACGAATGAGTAGGCTATTAATAACTCATTTAAAATCAAAAG
GATGTCATAAACTTATCCTTTTAAATAGAAATATTGATAGAGCATTAAATCTTGCTCAAGACTTTCCTGATTTAGAGATT
GTTTGTAGAGGGTTAAATGAATTAGAAGAAAACATATCACTATCTTCCATTGTTTTCACCAGTACTGCTTCTGAAGAGCC
AATTATTGATCTCGCAAAAATTGAAAAATTAAATTTGAGTAATAGACTTAAATTTATTGATATTGGTGTACCGAGAAATA
TATCTAATGATGTCAAACAACATCAATTTGTAAAATCATTTGATGTTGATGACTTACAAGAGGTAGTTTCAAGAAATCAA
GAATTTAGACAGAAAATAGCAAAGGAAGCGGAATCTTTAGTAGAAGAAGAAAGGATCATTTTTCTAGAATGGTGGGCAAG
TTTAGAGGCCGTTCCAGTAATTAATAAACTTAGATCAGATTTGGAGTTGATTAGAAAAGAGGAATTGCAAAAAGCACTTA
GCAGAATGGGACCAGATTTTTCGGCTCGAGAAAGAAAAGTTGTGGAAGCTCTGACTAAAGGAATAATTAATAAAATACTT
CATACGCCGGTCACCAAGTTGAGAAGTCCTCAATCAAGAGAAGAAAGACAAGTTTCTTTGAAAATCGTTGAAAAATTGTT
TTCTTTGGTAGAAGAGGAACAAAATAACTAA

Upstream 100 bases:

>100_bases
GGTTATTAGTACATTAGATAGTACTGCAAGGTTCACAAATACTGTCCATATAAAAGATGGTGCTAAGAGTATCAGCCTTT
AAAAATTCATTGTTGATATT

Downstream 100 bases:

>100_bases
CTTTTTTCGATTTATATTAAGTTTTTCCAGTGATTTATCGAAATACCTTTGTAAACTGACCATTTGTATTTCTAAATATG
CACATAATCAGTTACTTTAA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRMEIYALVKDKNTGISSIKEFISEYSGII
FEDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGT
GAVSISSAAVELAQLKIGQEKGFDTLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
VCRGLNELEENISLSSIVFTSTASEEPIIDLAKIEKLNLSNRLKFIDIGVPRNISNDVKQHQFVKSFDVDDLQEVVSRNQ
EFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKIL
HTPVTKLRSPQSREERQVSLKIVEKLFSLVEEEQNN

Sequences:

>Translated_436_residues
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRMEIYALVKDKNTGISSIKEFISEYSGII
FEDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGT
GAVSISSAAVELAQLKIGQEKGFDTLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
VCRGLNELEENISLSSIVFTSTASEEPIIDLAKIEKLNLSNRLKFIDIGVPRNISNDVKQHQFVKSFDVDDLQEVVSRNQ
EFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKIL
HTPVTKLRSPQSREERQVSLKIVEKLFSLVEEEQNN
>Mature_436_residues
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRMEIYALVKDKNTGISSIKEFISEYSGII
FEDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGT
GAVSISSAAVELAQLKIGQEKGFDTLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
VCRGLNELEENISLSSIVFTSTASEEPIIDLAKIEKLNLSNRLKFIDIGVPRNISNDVKQHQFVKSFDVDDLQEVVSRNQ
EFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKIL
HTPVTKLRSPQSREERQVSLKIVEKLFSLVEEEQNN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=413, Percent_Identity=34.3825665859564, Blast_Score=208, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 48928; Mature: 48928

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRMEIYALVK
CEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DKNTGISSIKEFISEYSGIIFEDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQ
CCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHEECCCHHHHH
VKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGTGAVSISSAAVELAQLKIGQE
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC
KGFDTLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
CCCHHHEEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHH
VCRGLNELEENISLSSIVFTSTASEEPIIDLAKIEKLNLSNRLKFIDIGVPRNISNDVKQ
HHHHHHHHHHCCCHHHEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHH
HQFVKSFDVDDLQEVVSRNQEFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSD
HHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHHHHHHHHHHH
LELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKILHTPVTKLRSPQSREERQVSL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
KIVEKLFSLVEEEQNN
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRMEIYALVK
CEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DKNTGISSIKEFISEYSGIIFEDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQ
CCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHEECCCHHHHH
VKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGTGAVSISSAAVELAQLKIGQE
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC
KGFDTLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
CCCHHHEEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHH
VCRGLNELEENISLSSIVFTSTASEEPIIDLAKIEKLNLSNRLKFIDIGVPRNISNDVKQ
HHHHHHHHHHCCCHHHEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHH
HQFVKSFDVDDLQEVVSRNQEFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSD
HHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHHHHHHHHHHH
LELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKILHTPVTKLRSPQSREERQVSL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
KIVEKLFSLVEEEQNN
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA