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The map label for this gene is proA [H]

Identifier: 123968181

GI number: 123968181

Start: 568199

End: 569509

Strand: Direct

Name: proA [H]

Synonym: A9601_06461

Alternate gene names: 123968181

Gene position: 568199-569509 (Clockwise)

Preceding gene: 123968180

Following gene: 123968182

Centisome position: 34.03

GC content: 31.81

Gene sequence:

>1311_bases
ATGGCTAATATCTTTGAAGTGCCCCAACCAGGTAATGATCTTTTAGAAAAAGCTAATAAAGTTCGTTTGGCATCAATAGA
AATAAGTCAAACTGAAAACCAAAATCGAATTAAAGCCTTAAATTTTATGGCTGATTATCTAGAAAAAAATTCTTATGAAA
TATTAGATGCTAATAATGCGGATTATTCAAGTGCACAAAAAAAAGGTATTTCTAGGGCTTTACTTTCTAGATTAAAGTTA
TCAAAATTAAAATTAAATTCAGGAATTGAAGGAGTAAGAAAAGTTGGAGACTTAGCTGATCCTGTAAATCAAGTTCAAAT
AAAAAGAGAGCTTTCAAAGGGATTATTCTTAGAAAGAAAAACTGTACCAATTGGTGTTTTAGGGGTTATTTTTGAATCAA
GGCCAGATGCCGTGATGCAGATTAGTTCATTAGCAATAAGATCAGGTAATGGAGTAATGCTAAAGGGTGGTAGTGAAGCT
AATTTAACAAATACAGCAATAGTCAAGGCATTGCAAGAAGGTTTAAATGCATCAGGTCTTGATAAAAATGCAATATGTTT
ACTAACAAGCAGAAAAGATAGCATGGCAATGTTAAATCTTGAGAAATACATTAATTTAATAATTCCAAGAGGAAGTAATG
AATTAGTTAAATTTATTCAGGAGAATACAAGAATTCCTGTGTTAGGTCATGCTGATGGAATTTGTCATTTGTTTATAGAT
ATTGAGGCAAATCTAGAGATGGCTTTATCAGTTGCTTTGGACAGCAAAATTCAATATCCTGCAGCATGTAATGCTATCGA
AACTTTATTACTCCATAAAGATATTGCACCAACTTTTTTAGAAAAGGCCATCCCTTTATTTAAATCTAATGATGTTAAAT
TAATTGGAGATATGAGATCAGTTGAATTAGGGGTAAAGTATGAGGCTAGTCTAGAAGATTGGAAAACTGAATATTTGGAT
TTAATTTTGTCGATAAAAATTGTTGATGATCTCGAGGAGGCAATCACACATATTCAAAAATATAGTTCAAAACATACAGA
TGGAATAATTACTGAAAATTCACATACTGCCAATAAATTTATGAATGTAATTGATAGTGCAGGTGTTTTTCATAATTGCT
CTACTAGGTTTGCAGATGGCTTTAGATATGGATTCGGAGCTGAAGTTGGTATATCTACTCAAACTCTTCCACCAAGGGGA
CCTGTAGGTCTAGAAGGTTTGGTAACTTATAAATATTTCCTAAAGGGTGATGGGAATATAGTTGATGATTTTTCATCAGG
AAAGGCTATCTATACACATAAAGATCTTTAA

Upstream 100 bases:

>100_bases
GAAAAGTCAAGTTCAGTTATTTTTTAGATATTAATTTACAAAGAAATTTACTTTAAAGAATCTTTAATTTGAATTATTAT
TAAATTAACTAAAAAATATT

Downstream 100 bases:

>100_bases
AACTTTTAAAGATGGAAACTTTTTTAAAAATTGAGAATATTAAGCTTTGGGCTAGGGTTGGCGTACTTGATGAAGAAAGG
GAATTAGGACAACTATTTAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MANIFEVPQPGNDLLEKANKVRLASIEISQTENQNRIKALNFMADYLEKNSYEILDANNADYSSAQKKGISRALLSRLKL
SKLKLNSGIEGVRKVGDLADPVNQVQIKRELSKGLFLERKTVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEA
NLTNTAIVKALQEGLNASGLDKNAICLLTSRKDSMAMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
IEANLEMALSVALDSKIQYPAACNAIETLLLHKDIAPTFLEKAIPLFKSNDVKLIGDMRSVELGVKYEASLEDWKTEYLD
LILSIKIVDDLEEAITHIQKYSSKHTDGIITENSHTANKFMNVIDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYKYFLKGDGNIVDDFSSGKAIYTHKDL

Sequences:

>Translated_436_residues
MANIFEVPQPGNDLLEKANKVRLASIEISQTENQNRIKALNFMADYLEKNSYEILDANNADYSSAQKKGISRALLSRLKL
SKLKLNSGIEGVRKVGDLADPVNQVQIKRELSKGLFLERKTVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEA
NLTNTAIVKALQEGLNASGLDKNAICLLTSRKDSMAMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
IEANLEMALSVALDSKIQYPAACNAIETLLLHKDIAPTFLEKAIPLFKSNDVKLIGDMRSVELGVKYEASLEDWKTEYLD
LILSIKIVDDLEEAITHIQKYSSKHTDGIITENSHTANKFMNVIDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYKYFLKGDGNIVDDFSSGKAIYTHKDL
>Mature_435_residues
ANIFEVPQPGNDLLEKANKVRLASIEISQTENQNRIKALNFMADYLEKNSYEILDANNADYSSAQKKGISRALLSRLKLS
KLKLNSGIEGVRKVGDLADPVNQVQIKRELSKGLFLERKTVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEAN
LTNTAIVKALQEGLNASGLDKNAICLLTSRKDSMAMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFIDI
EANLEMALSVALDSKIQYPAACNAIETLLLHKDIAPTFLEKAIPLFKSNDVKLIGDMRSVELGVKYEASLEDWKTEYLDL
ILSIKIVDDLEEAITHIQKYSSKHTDGIITENSHTANKFMNVIDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGP
VGLEGLVTYKYFLKGDGNIVDDFSSGKAIYTHKDL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=435, Percent_Identity=42.9885057471264, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI21361368, Length=435, Percent_Identity=42.9885057471264, Blast_Score=338, Evalue=4e-93,
Organism=Escherichia coli, GI1786438, Length=404, Percent_Identity=39.6039603960396, Blast_Score=303, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17569967, Length=430, Percent_Identity=43.7209302325581, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17569969, Length=430, Percent_Identity=43.7209302325581, Blast_Score=355, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6324899, Length=442, Percent_Identity=41.6289592760181, Blast_Score=339, Evalue=6e-94,
Organism=Drosophila melanogaster, GI21357643, Length=426, Percent_Identity=43.8967136150235, Blast_Score=337, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 47949; Mature: 47818

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIFEVPQPGNDLLEKANKVRLASIEISQTENQNRIKALNFMADYLEKNSYEILDANNA
CCCCCCCCCCCHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCC
DYSSAQKKGISRALLSRLKLSKLKLNSGIEGVRKVGDLADPVNQVQIKRELSKGLFLERK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEC
TVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEANLTNTAIVKALQEGLNASGL
CCCEEEEEEEECCCCHHHHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
DKNAICLLTSRKDSMAMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
CCCEEEEEECCCCCHHHEEHHHHEEEEECCCCHHHHHHHHHCCCCEEEECCCCEEEEEEE
IEANLEMALSVALDSKIQYPAACNAIETLLLHKDIAPTFLEKAIPLFKSNDVKLIGDMRS
EECCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCEEEEECCEE
VELGVKYEASLEDWKTEYLDLILSIKIVDDLEEAITHIQKYSSKHTDGIITENSHTANKF
EEECEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHH
MNVIDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYKYFLKGDGNI
HHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCE
VDDFSSGKAIYTHKDL
EECCCCCCEEEEECCC
>Mature Secondary Structure 
ANIFEVPQPGNDLLEKANKVRLASIEISQTENQNRIKALNFMADYLEKNSYEILDANNA
CCCCCCCCCCHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCC
DYSSAQKKGISRALLSRLKLSKLKLNSGIEGVRKVGDLADPVNQVQIKRELSKGLFLERK
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEC
TVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEANLTNTAIVKALQEGLNASGL
CCCEEEEEEEECCCCHHHHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
DKNAICLLTSRKDSMAMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
CCCEEEEEECCCCCHHHEEHHHHEEEEECCCCHHHHHHHHHCCCCEEEECCCCEEEEEEE
IEANLEMALSVALDSKIQYPAACNAIETLLLHKDIAPTFLEKAIPLFKSNDVKLIGDMRS
EECCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCEEEEECCEE
VELGVKYEASLEDWKTEYLDLILSIKIVDDLEEAITHIQKYSSKHTDGIITENSHTANKF
EEECEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHH
MNVIDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYKYFLKGDGNI
HHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCE
VDDFSSGKAIYTHKDL
EECCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA