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The map label for this gene is pyrC [H]

Identifier: 123968160

GI number: 123968160

Start: 547016

End: 548065

Strand: Direct

Name: pyrC [H]

Synonym: A9601_06251

Alternate gene names: 123968160

Gene position: 547016-548065 (Clockwise)

Preceding gene: 123968158

Following gene: 123968161

Centisome position: 32.76

GC content: 31.33

Gene sequence:

>1050_bases
TTGAAGACTTTAAACATAATAAAACCTGATGATTGGCATTTACATTTAAGAGAAGGTCTTGTATTAAAAAATATTATTCA
GTTTACTTCGGAATATTTTGGAAGAGCGATTGTCATGCCAAATACAAAAAGTCCCATAACATCAATCAATAGAGCTATTT
CTTATAGAAAATCTATTGTTGAAGCGTTACCAGAAAGTTCCAAGTTTGAACCATTAATGACAATTTATCTTACAGATGAG
ACTGATAAACGGGAACTAATTAATGGTTTTAAAAATAATGTTTTTTTTGCAGCTAAATTATATCCTGCTAATGCCACAAC
AAATTCCAGTCATGGAGTTAGGAAAATAGAAAATTTATATAAGATCTTTGAATTAATGCAAGATTCTGGAATGCCTCTTT
TAATTCATGGAGAAGTGACTGATTCTGAAGTAGATGTATTCGATAGAGAAGAAGTTTTTATAGATAAAGAACTTTCTCAA
ATAACCAAAAGATTTCCAAAATTAAAAATCGTTCTAGAACATATAACCACCTCTTATGCAGTGGATTTTGTTCAAGAAAA
TAATATTGGGGCTACTATCACTCCGCATCATTTGCATATAAATAGAAATGCAATGTTTTTTGGAGGCTTAAATAGTGATT
TTTACTGCTTACCAGTTGCTAAGAGGGAAAATAATAGACTCGCTTTAAGAAAAGCGGCAACAAGTGGGAAAAAATGTTTT
TTCTTGGGGACTGACTCTGCTCCACACCTTAGGAAGTGGAAGGCTTTTTGTGGATGTGCAGGCATTTTTAATTCGCCAGT
AGCATTAGAAAGCTATTTAACAGTTTTCGAAGAGGAGGATGCTTTAGATAATTTTGAAAAGTTTGCAAGTTTGAATGGCC
CTAATTTTTATAATGTTCCCCCAAACAAAGAGAAATTAAAATTAGTTTCTAGACCTTATAAAATTAAAGAATATATTGAT
GTTGTTGAAGAAAAAAATATTGTCGGACAAATAAAACCATTTCATGCAGGTGAAACTTTACAATGGCAAGTAGAAGGAAT
AGCAAATTAA

Upstream 100 bases:

>100_bases
ATAATAAAAATTTTCTTAATTGGTTAATAACTATCCTCGAATATCTATAATTGATTGTCAATTTTAATTTGCTGTTAAAA
TTGATTAAATAGAAAAAATC

Downstream 100 bases:

>100_bases
AAAATTATATTTAATCTGACAATTAAAAGTGTAAATATTCCAATTTTTCTTGGTTAAATGGGTTACTTTCAGCTACGATT
AGAAAGCGCAAATTCCTTTG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKTLNIIKPDDWHLHLREGLVLKNIIQFTSEYFGRAIVMPNTKSPITSINRAISYRKSIVEALPESSKFEPLMTIYLTDE
TDKRELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLYKIFELMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQ
ITKRFPKLKIVLEHITTSYAVDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGKKCF
FLGTDSAPHLRKWKAFCGCAGIFNSPVALESYLTVFEEEDALDNFEKFASLNGPNFYNVPPNKEKLKLVSRPYKIKEYID
VVEEKNIVGQIKPFHAGETLQWQVEGIAN

Sequences:

>Translated_349_residues
MKTLNIIKPDDWHLHLREGLVLKNIIQFTSEYFGRAIVMPNTKSPITSINRAISYRKSIVEALPESSKFEPLMTIYLTDE
TDKRELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLYKIFELMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQ
ITKRFPKLKIVLEHITTSYAVDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGKKCF
FLGTDSAPHLRKWKAFCGCAGIFNSPVALESYLTVFEEEDALDNFEKFASLNGPNFYNVPPNKEKLKLVSRPYKIKEYID
VVEEKNIVGQIKPFHAGETLQWQVEGIAN
>Mature_349_residues
MKTLNIIKPDDWHLHLREGLVLKNIIQFTSEYFGRAIVMPNTKSPITSINRAISYRKSIVEALPESSKFEPLMTIYLTDE
TDKRELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLYKIFELMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQ
ITKRFPKLKIVLEHITTSYAVDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGKKCF
FLGTDSAPHLRKWKAFCGCAGIFNSPVALESYLTVFEEEDALDNFEKFASLNGPNFYNVPPNKEKLKLVSRPYKIKEYID
VVEEKNIVGQIKPFHAGETLQWQVEGIAN

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=347, Percent_Identity=50.7204610951009, Blast_Score=367, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323452, Length=359, Percent_Identity=33.4261838440111, Blast_Score=172, Evalue=6e-44,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39815; Mature: 39815

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLNIIKPDDWHLHLREGLVLKNIIQFTSEYFGRAIVMPNTKSPITSINRAISYRKSIV
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHH
EALPESSKFEPLMTIYLTDETDKRELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLY
HHCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
KIFELMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQITKRFPKLKIVLEHITTSYA
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGKKCF
EEEEECCCCCCEECCCEEEEECCEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEE
FLGTDSAPHLRKWKAFCGCAGIFNSPVALESYLTVFEEEDALDNFEKFASLNGPNFYNVP
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCC
PNKEKLKLVSRPYKIKEYIDVVEEKNIVGQIKPFHAGETLQWQVEGIAN
CCHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MKTLNIIKPDDWHLHLREGLVLKNIIQFTSEYFGRAIVMPNTKSPITSINRAISYRKSIV
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHH
EALPESSKFEPLMTIYLTDETDKRELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLY
HHCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
KIFELMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQITKRFPKLKIVLEHITTSYA
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VDFVQENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGKKCF
EEEEECCCCCCEECCCEEEEECCEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEE
FLGTDSAPHLRKWKAFCGCAGIFNSPVALESYLTVFEEEDALDNFEKFASLNGPNFYNVP
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCC
PNKEKLKLVSRPYKIKEYIDVVEEKNIVGQIKPFHAGETLQWQVEGIAN
CCHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA