Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 123968060

GI number: 123968060

Start: 455778

End: 456332

Strand: Direct

Name: gmk [H]

Synonym: A9601_05231

Alternate gene names: 123968060

Gene position: 455778-456332 (Clockwise)

Preceding gene: 123968056

Following gene: 123968062

Centisome position: 27.29

GC content: 31.35

Gene sequence:

>555_bases
ATGAAAGATCAAAAAAAACTTATTATCCTTACTGGACCCAGCGGGGTAGGTAAAGGAACAGTTGTCAAAAAAATATTATG
TAAAGAAAAAAATTTTTGGCTTTCAATATCTGCAACTACTAGAGAACCTAGAGAGGGAGAGAAGGACGGAGAAAATTATT
ATTTCTTAAACCAAGAAAAGTTTAAAGAAATGATTGAACAAAATCTTTTCCTTGAATGGGCTCAATTTGCTGGAAACTAC
TATGGAACGCCTTTGTCTTCTGTTAATGAGAAAATAAAAAAGGGATTTACCGTACTACTTGAAATTGAAGTAGAGGGTGC
AAGGCAAATAAAAAATAAGTTTCCTAATTCACAGTCAATATTTTTACTTCCTCCGGATAAAGAAGAGTTAGAGAGAAGAA
TAAGAAATAGAGGTACCGAAAAAGAAGAGGCAATTAAAAAAAGACTCTCAAGGGCTAATTATGAGATTTCAGTATCAAAT
GAATTTGATTTTGCATTAACAAATCACGATGTTGATGAAACAGCAAAAAAAATAATCAAGTTAATAAAAACTTGA

Upstream 100 bases:

>100_bases
GACAGATCTAATAGATGTAATATCCATTATCTGTGGAACACCTTTTTGCATTATTACTTTTTAATTCGCAAGAAGTTTAT
TTTACTGTAAAAAATTTAAT

Downstream 100 bases:

>100_bases
TTATTTTCTATTTATCAACTCATTGGATGGAATAATAAATCTGGGAAAAACCTATTAAATTCAATAATTATTCCAGCTGT
AAGGCTTAGCCAAATTGCTG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKDQKKLIILTGPSGVGKGTVVKKILCKEKNFWLSISATTREPREGEKDGENYYFLNQEKFKEMIEQNLFLEWAQFAGNY
YGTPLSSVNEKIKKGFTVLLEIEVEGARQIKNKFPNSQSIFLLPPDKEELERRIRNRGTEKEEAIKKRLSRANYEISVSN
EFDFALTNHDVDETAKKIIKLIKT

Sequences:

>Translated_184_residues
MKDQKKLIILTGPSGVGKGTVVKKILCKEKNFWLSISATTREPREGEKDGENYYFLNQEKFKEMIEQNLFLEWAQFAGNY
YGTPLSSVNEKIKKGFTVLLEIEVEGARQIKNKFPNSQSIFLLPPDKEELERRIRNRGTEKEEAIKKRLSRANYEISVSN
EFDFALTNHDVDETAKKIIKLIKT
>Mature_184_residues
MKDQKKLIILTGPSGVGKGTVVKKILCKEKNFWLSISATTREPREGEKDGENYYFLNQEKFKEMIEQNLFLEWAQFAGNY
YGTPLSSVNEKIKKGFTVLLEIEVEGARQIKNKFPNSQSIFLLPPDKEELERRIRNRGTEKEEAIKKRLSRANYEISVSN
EFDFALTNHDVDETAKKIIKLIKT

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=171, Percent_Identity=36.8421052631579, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI226874833, Length=171, Percent_Identity=36.8421052631579, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=171, Percent_Identity=36.8421052631579, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI38570142, Length=183, Percent_Identity=28.9617486338798, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI4505237, Length=176, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI262118259, Length=176, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI262118255, Length=176, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI21389483, Length=183, Percent_Identity=27.3224043715847, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI21361598, Length=186, Percent_Identity=24.7311827956989, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI186700629, Length=183, Percent_Identity=25.6830601092896, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI186700627, Length=183, Percent_Identity=25.6830601092896, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI186972120, Length=183, Percent_Identity=25.6830601092896, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI52630447, Length=186, Percent_Identity=22.0430107526882, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI14780902, Length=135, Percent_Identity=24.4444444444444, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI111154074, Length=114, Percent_Identity=27.1929824561404, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=183, Percent_Identity=41.5300546448087, Blast_Score=167, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=41.2087912087912, Blast_Score=136, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=40.3314917127072, Blast_Score=135, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71988048, Length=182, Percent_Identity=25.2747252747253, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988041, Length=182, Percent_Identity=25.2747252747253, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71984092, Length=158, Percent_Identity=28.4810126582279, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557440, Length=183, Percent_Identity=24.5901639344262, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=180, Percent_Identity=41.6666666666667, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21356141, Length=169, Percent_Identity=41.4201183431953, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI161077626, Length=183, Percent_Identity=23.4972677595628, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554489, Length=183, Percent_Identity=23.4972677595628, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640542, Length=183, Percent_Identity=23.4972677595628, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554481, Length=183, Percent_Identity=23.4972677595628, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI116007136, Length=183, Percent_Identity=23.4972677595628, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI85724806, Length=183, Percent_Identity=23.4972677595628, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI85816106, Length=217, Percent_Identity=26.7281105990783, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI85816281, Length=217, Percent_Identity=26.7281105990783, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45551002, Length=217, Percent_Identity=26.7281105990783, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21294; Mature: 21294

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDQKKLIILTGPSGVGKGTVVKKILCKEKNFWLSISATTREPREGEKDGENYYFLNQEK
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEECHHH
FKEMIEQNLFLEWAQFAGNYYGTPLSSVNEKIKKGFTVLLEIEVEGARQIKNKFPNSQSI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEEECCHHHHHHHCCCCCEE
FLLPPDKEELERRIRNRGTEKEEAIKKRLSRANYEISVSNEFDFALTNHDVDETAKKIIK
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCEEECCCCHHHHHHHHHH
LIKT
HHCC
>Mature Secondary Structure
MKDQKKLIILTGPSGVGKGTVVKKILCKEKNFWLSISATTREPREGEKDGENYYFLNQEK
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEECHHH
FKEMIEQNLFLEWAQFAGNYYGTPLSSVNEKIKKGFTVLLEIEVEGARQIKNKFPNSQSI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEEECCHHHHHHHCCCCCEE
FLLPPDKEELERRIRNRGTEKEEAIKKRLSRANYEISVSNEFDFALTNHDVDETAKKIIK
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCEEECCCCHHHHHHHHHH
LIKT
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA