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The map label for this gene is cyoE [H]

Identifier: 123968040

GI number: 123968040

Start: 438261

End: 439262

Strand: Direct

Name: cyoE [H]

Synonym: A9601_05031

Alternate gene names: 123968040

Gene position: 438261-439262 (Clockwise)

Preceding gene: 123968039

Following gene: 123968041

Centisome position: 26.24

GC content: 38.82

Gene sequence:

>1002_bases
ATGAACAGTAGTAACTTAGAAAACTTGAACTATAAATCTTCAATTAGGGATGAAGTTGTACCTTCAAGAAAAAAATTAAC
TTTGCCGCCTTGGCTTGAAGTAGCAAAACCTAGATTAATACCACTTTTACTGGCCACAACTTTAGGAGGAATGGCTTTAA
CAGAAGAATGGCCTTTGTCTTCCCCGAAACTTATCTGCACTCTAGGAGGAGGCGCTTTGGCAGCAGCAGCAGCAGGAGCT
CTTAATTGCTTGTGGGAAATGGAATTAGATAAAAGGATGACAAGAACAAGCAAAAGGGCCTTGCCAGCTGGAAAGTTGTC
ATCTGAGACTGTATTTTTAGCCGCCGTTTCATGTACTTTGGCAGCTTCGATGCTTTTAGTAAGTGGTGTAAATTATTTGG
CTGCGGGTTTAACTCTTCTTGGTTTATTTAGCTACGTAATTTTATATACAGTTATTTTGAAACCTCGTACAACAAAAAAC
ATTGTTTTCGGAGGAGTTGCTGGTGCGATACCACCCTTAGTTGGAGCGTCTGCTGCCACAGGGCATGTAGGTCTTAGTGG
TTGGTGGTTGTTTGGTTTAGTAATGTTATGGACCCCAGCTCATTTTTGGGCACTTGCAATTTTGTTGAAGGATGATTACG
CATCTGTTGGTATTCCTATGCTCCCTTCTGTTAAAGGATCTGTTTTTACTGCTAAAGCGATTTCCCGTTACGGATGGGCA
ACAGTTTTAATGAGTATTATGGGAGTCTTTGCTCTACCTGAAGGGGGTCTTTTATACGGAATTATGTTATTGCCATTTAA
TGGAAGACTTTTGCAATTAATAAATGAATTAAAGAAATCTCCTGATGATCTTTCTAGAGCAAAGTCTCTTTTTAGGTGGT
CTATTCTCTACATGTTTGGCATTTGTCTTTTGTTATTAATTTCCAGAACCCAACTATCCGTAGAATTTGAGCAGCAATCT
ATGCAAATATTTTTATCTATTGTATCCCTGCTTAGTAATTAA

Upstream 100 bases:

>100_bases
CATTATTTATTGCGATATTAACAACATTAATTTTTAGAAATCCTTTTACCAAAAAAGGTCTAAACCACTCCCTTAATCCC
CAAACGGTCGGTATCAACTC

Downstream 100 bases:

>100_bases
ATTAGATGTAAAATGTATTTTAAGTAAATAGTAAGTTTGATGAATTATATAAAAGTTAAAGGGCTCTCAAAATCTTATTC
AGATATCAATGCATTAAAAA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MNSSNLENLNYKSSIRDEVVPSRKKLTLPPWLEVAKPRLIPLLLATTLGGMALTEEWPLSSPKLICTLGGGALAAAAAGA
LNCLWEMELDKRMTRTSKRALPAGKLSSETVFLAAVSCTLAASMLLVSGVNYLAAGLTLLGLFSYVILYTVILKPRTTKN
IVFGGVAGAIPPLVGASAATGHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSVFTAKAISRYGWA
TVLMSIMGVFALPEGGLLYGIMLLPFNGRLLQLINELKKSPDDLSRAKSLFRWSILYMFGICLLLLISRTQLSVEFEQQS
MQIFLSIVSLLSN

Sequences:

>Translated_333_residues
MNSSNLENLNYKSSIRDEVVPSRKKLTLPPWLEVAKPRLIPLLLATTLGGMALTEEWPLSSPKLICTLGGGALAAAAAGA
LNCLWEMELDKRMTRTSKRALPAGKLSSETVFLAAVSCTLAASMLLVSGVNYLAAGLTLLGLFSYVILYTVILKPRTTKN
IVFGGVAGAIPPLVGASAATGHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSVFTAKAISRYGWA
TVLMSIMGVFALPEGGLLYGIMLLPFNGRLLQLINELKKSPDDLSRAKSLFRWSILYMFGICLLLLISRTQLSVEFEQQS
MQIFLSIVSLLSN
>Mature_333_residues
MNSSNLENLNYKSSIRDEVVPSRKKLTLPPWLEVAKPRLIPLLLATTLGGMALTEEWPLSSPKLICTLGGGALAAAAAGA
LNCLWEMELDKRMTRTSKRALPAGKLSSETVFLAAVSCTLAASMLLVSGVNYLAAGLTLLGLFSYVILYTVILKPRTTKN
IVFGGVAGAIPPLVGASAATGHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSVFTAKAISRYGWA
TVLMSIMGVFALPEGGLLYGIMLLPFNGRLLQLINELKKSPDDLSRAKSLFRWSILYMFGICLLLLISRTQLSVEFEQQS
MQIFLSIVSLLSN

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=189, Percent_Identity=34.9206349206349, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786631, Length=275, Percent_Identity=29.8181818181818, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71998235, Length=269, Percent_Identity=29.368029739777, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=215, Percent_Identity=31.6279069767442, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921064, Length=286, Percent_Identity=32.5174825174825, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 35980; Mature: 35980

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSNLENLNYKSSIRDEVVPSRKKLTLPPWLEVAKPRLIPLLLATTLGGMALTEEWPLS
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCEECCCCCCC
SPKLICTLGGGALAAAAAGALNCLWEMELDKRMTRTSKRALPAGKLSSETVFLAAVSCTL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AASMLLVSGVNYLAAGLTLLGLFSYVILYTVILKPRTTKNIVFGGVAGAIPPLVGASAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHCHHHCCCCCC
GHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSVFTAKAISRYGWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
TVLMSIMGVFALPEGGLLYGIMLLPFNGRLLQLINELKKSPDDLSRAKSLFRWSILYMFG
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ICLLLLISRTQLSVEFEQQSMQIFLSIVSLLSN
HHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSSNLENLNYKSSIRDEVVPSRKKLTLPPWLEVAKPRLIPLLLATTLGGMALTEEWPLS
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCEECCCCCCC
SPKLICTLGGGALAAAAAGALNCLWEMELDKRMTRTSKRALPAGKLSSETVFLAAVSCTL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AASMLLVSGVNYLAAGLTLLGLFSYVILYTVILKPRTTKNIVFGGVAGAIPPLVGASAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHCHHHCCCCCC
GHVGLSGWWLFGLVMLWTPAHFWALAILLKDDYASVGIPMLPSVKGSVFTAKAISRYGWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
TVLMSIMGVFALPEGGLLYGIMLLPFNGRLLQLINELKKSPDDLSRAKSLFRWSILYMFG
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ICLLLLISRTQLSVEFEQQSMQIFLSIVSLLSN
HHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA