Click here to switch to the map view.

The map label for this gene is thiD [H]

Identifier: 123967932

GI number: 123967932

Start: 351857

End: 352636

Strand: Direct

Name: thiD [H]

Synonym: A9601_03951

Alternate gene names: 123967932

Gene position: 351857-352636 (Clockwise)

Preceding gene: 123967931

Following gene: 123967934

Centisome position: 21.07

GC content: 33.33

Gene sequence:

>780_bases
ATGTATTCTAAAATTGCACTTTCAATAGGCGGTAGTGACTCCGGGGGTGGAGCAGGCATACAGGCTGACTTGAGAACTTT
TATGGCCCTTAAAGTACATGGATGTTCTGTTATTACACGTATTACCGCACAAAATAGTATAGAGGTTACATGCGTTCAAC
CAGTAGAGAAGAAAACTTTATTAAATCAGTTAGATGCTTTATTCGCTGATTTTGGTATTGATGCCTTAAAAACTGGAATG
TTATTAAATGAAAGGATAATTAATGATACTGCTTCAAAATTAAATTCGTACAAAATAACCAAAATTATTGACCCAGTGAT
GGTTACAAGAACTGGTTCTAAATTACTGGAAGATTCTGCTATTAATGCTTATAAAAAACTCTTATTGCCAATTGCTGATT
TGCTAACTCCAAATATTTATGAAGCAAATCTACTTTCTGGTTTAGAAATAAGGAGTAAAGAAGATATCGAAAATTCCGCA
AGAAAAATTATTGGTCTTGGTGCTAAAGCGGTACTTATAAAAGGTGGCGGTTTAAAAGATATGAAAGGGAAGGATTTTTT
TCTTGACTTAAATGGTAGAAAAGAGTGGATTTTTAATAATTTTATAAATACAAAAAATACCCACGGTAGCGGCTGTACTT
TGAGTGCTGCTATTTGTGGTTACAAGGCTTTAGGTTTTGATCTATTTGATTCCATACAAAAAGCGAAATTATTTGTTGAG
AAATCTTTAGACAATTCTTATAAAATAGGATCTGGCCCTGGACCCTTAGGACATCATTAA

Upstream 100 bases:

>100_bases
AGAGCTATGGAATTGGAGTTAGATTTTTTTAATGCATATTCAGATTTCTGATTTAAATTAGAATTTATTTATAGTACTTT
CAAAAACAAGTTAATAAATT

Downstream 100 bases:

>100_bases
TTATTTATAGAAGTGGCGTTAGAACCACCATTTTCTGTAGGGCTTTTTTAAAAATAAGATTTCTTCAGTCTCCCATCCTC
CCTCCAACCACTCAAGATGC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MYSKIALSIGGSDSGGGAGIQADLRTFMALKVHGCSVITRITAQNSIEVTCVQPVEKKTLLNQLDALFADFGIDALKTGM
LLNERIINDTASKLNSYKITKIIDPVMVTRTGSKLLEDSAINAYKKLLLPIADLLTPNIYEANLLSGLEIRSKEDIENSA
RKIIGLGAKAVLIKGGGLKDMKGKDFFLDLNGRKEWIFNNFINTKNTHGSGCTLSAAICGYKALGFDLFDSIQKAKLFVE
KSLDNSYKIGSGPGPLGHH

Sequences:

>Translated_259_residues
MYSKIALSIGGSDSGGGAGIQADLRTFMALKVHGCSVITRITAQNSIEVTCVQPVEKKTLLNQLDALFADFGIDALKTGM
LLNERIINDTASKLNSYKITKIIDPVMVTRTGSKLLEDSAINAYKKLLLPIADLLTPNIYEANLLSGLEIRSKEDIENSA
RKIIGLGAKAVLIKGGGLKDMKGKDFFLDLNGRKEWIFNNFINTKNTHGSGCTLSAAICGYKALGFDLFDSIQKAKLFVE
KSLDNSYKIGSGPGPLGHH
>Mature_259_residues
MYSKIALSIGGSDSGGGAGIQADLRTFMALKVHGCSVITRITAQNSIEVTCVQPVEKKTLLNQLDALFADFGIDALKTGM
LLNERIINDTASKLNSYKITKIIDPVMVTRTGSKLLEDSAINAYKKLLLPIADLLTPNIYEANLLSGLEIRSKEDIENSA
RKIIGLGAKAVLIKGGGLKDMKGKDFFLDLNGRKEWIFNNFINTKNTHGSGCTLSAAICGYKALGFDLFDSIQKAKLFVE
KSLDNSYKIGSGPGPLGHH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=257, Percent_Identity=39.6887159533074, Blast_Score=189, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6325378, Length=266, Percent_Identity=29.6992481203008, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324997, Length=267, Percent_Identity=31.8352059925094, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324517, Length=267, Percent_Identity=29.9625468164794, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27955; Mature: 27955

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKIALSIGGSDSGGGAGIQADLRTFMALKVHGCSVITRITAQNSIEVTCVQPVEKKTL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCHHHHHH
LNQLDALFADFGIDALKTGMLLNERIINDTASKLNSYKITKIIDPVMVTRTGSKLLEDSA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHCCCEEECCCHHHHHHHH
INAYKKLLLPIADLLTPNIYEANLLSGLEIRSKEDIENSARKIIGLGAKAVLIKGGGLKD
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
MKGKDFFLDLNGRKEWIFNNFINTKNTHGSGCTLSAAICGYKALGFDLFDSIQKAKLFVE
CCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLDNSYKIGSGPGPLGHH
HCCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MYSKIALSIGGSDSGGGAGIQADLRTFMALKVHGCSVITRITAQNSIEVTCVQPVEKKTL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCHHHHHH
LNQLDALFADFGIDALKTGMLLNERIINDTASKLNSYKITKIIDPVMVTRTGSKLLEDSA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHCCCEEECCCHHHHHHHH
INAYKKLLLPIADLLTPNIYEANLLSGLEIRSKEDIENSARKIIGLGAKAVLIKGGGLKD
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
MKGKDFFLDLNGRKEWIFNNFINTKNTHGSGCTLSAAICGYKALGFDLFDSIQKAKLFVE
CCCCEEEEEECCCCHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KSLDNSYKIGSGPGPLGHH
HCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA