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The map label for this gene is pyrE [H]

Identifier: 123967835

GI number: 123967835

Start: 274689

End: 275249

Strand: Direct

Name: pyrE [H]

Synonym: A9601_02981

Alternate gene names: 123967835

Gene position: 274689-275249 (Clockwise)

Preceding gene: 123967833

Following gene: 123967836

Centisome position: 16.45

GC content: 31.91

Gene sequence:

>561_bases
ATGGGCAAATTTTCTAATAAATATGATCTAAATAAAGCAAAATTATTAAAACAGTTAATTGAAAAATCTTACAAAAAAGG
GAATTTCACTTTATCTTCAGGGAAAAAAAGTAATCATTACTTGAACTGTAAACCAGTGTCATTAAATGGCGAAGGCTTAA
ACTTAATCAGTGATTTATTTTTAGAGTTAAAGGACTCAAGGTCAAAAGCTGTAGCAGGATTGACATTAGGTGCAGACCCT
ATAGTAAGCGGATTAATTGTCAAAGCAGCTTTGCATGGCCTAGACCTTGATGGTTTAATAATTCGGAAAGAAATCAAAAA
ATACGGTACCAAAGCTGGAATAGAGGGCCCTAAATTAGAAGAAGGAACTTTGGTAACTGTCTTAGAGGATGTGGTTACAA
CTGCTGGTTCAGTAATAAAAGCTATAAAAAAATTACGAGAAAATAATTATGTTGTTGAGGAAGTTTTGTCTATAGTTGAT
AGGCAAGAAGGGGGATTAGAAGCCCTTGAAGATGAAAATGTTAAATTAAAGAGTCTTTTTACAATAAAAGACTTTTTATA
A

Upstream 100 bases:

>100_bases
TACAATATAAAAATAATATTTCAAAAAACACCTCATTAGGAAGTTTTTGTGAGATTTCTTTTTTTCTTCTAATCTTTAAA
TATCAGTTTAACTTTTACTA

Downstream 100 bases:

>100_bases
TTATTTCAAAATGCAAGATATAAAAAAAAAGTTTTGGCTTGAAAAATTTGATTGTTTTTCAATTACTGGAAAAGATGCCA
GGAAATTTTTGAATGGAATA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MGKFSNKYDLNKAKLLKQLIEKSYKKGNFTLSSGKKSNHYLNCKPVSLNGEGLNLISDLFLELKDSRSKAVAGLTLGADP
IVSGLIVKAALHGLDLDGLIIRKEIKKYGTKAGIEGPKLEEGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVEEVLSIVD
RQEGGLEALEDENVKLKSLFTIKDFL

Sequences:

>Translated_186_residues
MGKFSNKYDLNKAKLLKQLIEKSYKKGNFTLSSGKKSNHYLNCKPVSLNGEGLNLISDLFLELKDSRSKAVAGLTLGADP
IVSGLIVKAALHGLDLDGLIIRKEIKKYGTKAGIEGPKLEEGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVEEVLSIVD
RQEGGLEALEDENVKLKSLFTIKDFL
>Mature_185_residues
GKFSNKYDLNKAKLLKQLIEKSYKKGNFTLSSGKKSNHYLNCKPVSLNGEGLNLISDLFLELKDSRSKAVAGLTLGADPI
VSGLIVKAALHGLDLDGLIIRKEIKKYGTKAGIEGPKLEEGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVEEVLSIVDR
QEGGLEALEDENVKLKSLFTIKDFL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=168, Percent_Identity=27.3809523809524, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554964, Length=179, Percent_Identity=36.3128491620112, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17508631, Length=168, Percent_Identity=27.3809523809524, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17933654, Length=181, Percent_Identity=30.3867403314917, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031 [H]

Pfam domain/function: NA

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20333; Mature: 20202

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKFSNKYDLNKAKLLKQLIEKSYKKGNFTLSSGKKSNHYLNCKPVSLNGEGLNLISDLF
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEEEECCCCHHHHHHHH
LELKDSRSKAVAGLTLGADPIVSGLIVKAALHGLDLDGLIIRKEIKKYGTKAGIEGPKLE
HHHHCCCHHHHEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
EGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVEEVLSIVDRQEGGLEALEDENVKLKSLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHH
TIKDFL
HHHHCC
>Mature Secondary Structure 
GKFSNKYDLNKAKLLKQLIEKSYKKGNFTLSSGKKSNHYLNCKPVSLNGEGLNLISDLF
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEEEECCCCHHHHHHHH
LELKDSRSKAVAGLTLGADPIVSGLIVKAALHGLDLDGLIIRKEIKKYGTKAGIEGPKLE
HHHHCCCHHHHEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
EGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVEEVLSIVDRQEGGLEALEDENVKLKSLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHH
TIKDFL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA