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The map label for this gene is purH [H]

Identifier: 123967825

GI number: 123967825

Start: 266042

End: 267595

Strand: Reverse

Name: purH [H]

Synonym: A9601_02881

Alternate gene names: 123967825

Gene position: 267595-266042 (Counterclockwise)

Preceding gene: 123967827

Following gene: 123967820

Centisome position: 16.02

GC content: 31.98

Gene sequence:

>1554_bases
ATGTCTCCATTAGCTTTAGTAAGTGTCTCTGATAAAAAAAATATAATCCCATTTTGCAAGGAATTGGTAGAGCATTTCAA
TTATAAAATTCTATCAAGTGGAGGAACTGCCAAACATCTTATAGAGGCAAAAATTCCAGTTATTAAAGTTGCTGATTTTA
CTAATTCTCCGGAAATTCTTGGAGGAAGAGTTAAAACTTTACATCCAAAAATACACGGGGGAATATTAGCTATAAGAACT
GATGAGGAACACAAAAAAGATATAGAAGCTAACAATCTTGAGTTAATTGATTTGGTAGTTGTCAATTTATATCCTTTTAA
AAAAACTGTAGATGGGGGAGCTAAATGGGAAGATGCTATTGAAAATATCGATATCGGAGGGCCATCTATGATTCGTTCTG
CAGCTAAAAATCATAAAGATGTTTCCGTTTTAGTAGATTCTAGTCAGTATCAAAGTTTTCTTGAAGAAAGTAAAAAAGGT
GAATTGAAAGACTCATATAAAGCAAAATTAGCCCTTGAAGCTTTTCAACATACAGCAGATTATGACACTGCAATATCTAA
TTGGATAAGAAAAGAAAGAGATTTACAATCTTCTAAATATATTGAATCTTATCCACTAATCAAAACCTTAAGATATGGAG
AGAATCCACATCAAAAAGCTTTTTGGTATGGTTTAAGTAACATTGGATGGAACTCAGCAGAGCAATTACAAGGAAAAGAC
TTAAGTTATAACAATCTATTAGATCTAGAGTCGGCACTTTCAACAGTTTTAGAATTTGGCTACACAGAAAAAGATGAACT
TGCAACCGATATGGTTGCCTCTGTTATTTTAAAACACAATAATCCTTGTGGTGCCTCTATGAGTAATTCAGCTTCTAAAG
CATTTTTGAATGCTTTAGAATGCGACTCTGTAAGTGCATTTGGAGGAATAGTTGCTTTTAATTCAAATGTTGATAGTGAG
ACAGCAATTCACCTCAAAGATATTTTCTTAGAGTGTGTCGTCGCTCCATCTTTTGATGAAGAAGCTTTAGAAATTTTAAA
AGTTAAAAAGAATTTAAGAATCTTAAAGATTTCAAAAGATCAACTTCCACAAAAGAATCAAAATTCTACTAAATCAATAA
TGGGAGGATTACTAGTTCAAGATACTGACGATAGTGAAGAAAAAACTGAAAATTGGATTTCAGTAACTAATAAAAATCCA
AGTAATCAAATTAACTTAGATCTAAATTTTGCATGGAAAATTTGTAAACATGTTAAATCTAATGCAATTGTTATTGCAAA
AGACCAAAAAACTATTGGTATTGGAGCTGGGCAAATGAACAGAGTTGGAGCAGCAAAAATTGCATTAAAAGCAGCTGGAA
GGTTATGTTCTGATGCTGTCTTGGCTAGCGATGGGTTTTTCCCATTTGCAGATACTGTAGAAATAGCAAATGAATATGGA
ATAAAAGCTATTATTCAACCTGGAGGAAGTCTAAGAGACCAAGAAAGTATTGATATGTGTAATTCAAAAGGAATCTCAAT
GGTATTTACGCAAAAAAGACATTTTTTACATTAA

Upstream 100 bases:

>100_bases
AAATAATTCTATGAGTTGCAGTTTGAGAGCTAATCGAGACAAATTCATGATTGATGGCATATTTCATGTTTATATTCTTA
AGTAAGTAAACTTTCCCATA

Downstream 100 bases:

>100_bases
ATTATGTTGATTTTGGATAATATGTAATCTTGTTAGTTTTTCTAAATAAAGATAGCCTGCCTGGACCTGCACATAGAAAG
TAGAGGGAAATAGCCCCGTA

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSPLALVSVSDKKNIIPFCKELVEHFNYKILSSGGTAKHLIEAKIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAIRT
DEEHKKDIEANNLELIDLVVVNLYPFKKTVDGGAKWEDAIENIDIGGPSMIRSAAKNHKDVSVLVDSSQYQSFLEESKKG
ELKDSYKAKLALEAFQHTADYDTAISNWIRKERDLQSSKYIESYPLIKTLRYGENPHQKAFWYGLSNIGWNSAEQLQGKD
LSYNNLLDLESALSTVLEFGYTEKDELATDMVASVILKHNNPCGASMSNSASKAFLNALECDSVSAFGGIVAFNSNVDSE
TAIHLKDIFLECVVAPSFDEEALEILKVKKNLRILKISKDQLPQKNQNSTKSIMGGLLVQDTDDSEEKTENWISVTNKNP
SNQINLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALKAAGRLCSDAVLASDGFFPFADTVEIANEYG
IKAIIQPGGSLRDQESIDMCNSKGISMVFTQKRHFLH

Sequences:

>Translated_517_residues
MSPLALVSVSDKKNIIPFCKELVEHFNYKILSSGGTAKHLIEAKIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAIRT
DEEHKKDIEANNLELIDLVVVNLYPFKKTVDGGAKWEDAIENIDIGGPSMIRSAAKNHKDVSVLVDSSQYQSFLEESKKG
ELKDSYKAKLALEAFQHTADYDTAISNWIRKERDLQSSKYIESYPLIKTLRYGENPHQKAFWYGLSNIGWNSAEQLQGKD
LSYNNLLDLESALSTVLEFGYTEKDELATDMVASVILKHNNPCGASMSNSASKAFLNALECDSVSAFGGIVAFNSNVDSE
TAIHLKDIFLECVVAPSFDEEALEILKVKKNLRILKISKDQLPQKNQNSTKSIMGGLLVQDTDDSEEKTENWISVTNKNP
SNQINLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALKAAGRLCSDAVLASDGFFPFADTVEIANEYG
IKAIIQPGGSLRDQESIDMCNSKGISMVFTQKRHFLH
>Mature_516_residues
SPLALVSVSDKKNIIPFCKELVEHFNYKILSSGGTAKHLIEAKIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAIRTD
EEHKKDIEANNLELIDLVVVNLYPFKKTVDGGAKWEDAIENIDIGGPSMIRSAAKNHKDVSVLVDSSQYQSFLEESKKGE
LKDSYKAKLALEAFQHTADYDTAISNWIRKERDLQSSKYIESYPLIKTLRYGENPHQKAFWYGLSNIGWNSAEQLQGKDL
SYNNLLDLESALSTVLEFGYTEKDELATDMVASVILKHNNPCGASMSNSASKAFLNALECDSVSAFGGIVAFNSNVDSET
AIHLKDIFLECVVAPSFDEEALEILKVKKNLRILKISKDQLPQKNQNSTKSIMGGLLVQDTDDSEEKTENWISVTNKNPS
NQINLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALKAAGRLCSDAVLASDGFFPFADTVEIANEYGI
KAIIQPGGSLRDQESIDMCNSKGISMVFTQKRHFLH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=478, Percent_Identity=36.1924686192469, Blast_Score=233, Evalue=4e-61,
Organism=Escherichia coli, GI1790439, Length=536, Percent_Identity=45.7089552238806, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71985564, Length=476, Percent_Identity=35.9243697478992, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71985574, Length=306, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323056, Length=473, Percent_Identity=36.9978858350951, Blast_Score=257, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6323768, Length=469, Percent_Identity=36.6737739872068, Blast_Score=254, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24649832, Length=473, Percent_Identity=34.6723044397463, Blast_Score=226, Evalue=4e-59,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 57055; Mature: 56923

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLALVSVSDKKNIIPFCKELVEHFNYKILSSGGTAKHLIEAKIPVIKVADFTNSPEIL
CCCEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCEEEEECCCCCCHHC
GGRVKTLHPKIHGGILAIRTDEEHKKDIEANNLELIDLVVVNLYPFKKTVDGGAKWEDAI
CCCEEEECCCCCCCEEEEECCHHHHHCCCCCCEEEEEEEEEEEECCHHCCCCCCHHHHHH
ENIDIGGPSMIRSAAKNHKDVSVLVDSSQYQSFLEESKKGELKDSYKAKLALEAFQHTAD
HCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
YDTAISNWIRKERDLQSSKYIESYPLIKTLRYGENPHQKAFWYGLSNIGWNSAEQLQGKD
HHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHCCCC
LSYNNLLDLESALSTVLEFGYTEKDELATDMVASVILKHNNPCGASMSNSASKAFLNALE
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
CDSVSAFGGIVAFNSNVDSETAIHLKDIFLECVVAPSFDEEALEILKVKKNLRILKISKD
CCCCHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECHH
QLPQKNQNSTKSIMGGLLVQDTDDSEEKTENWISVTNKNPSNQINLDLNFAWKICKHVKS
HCCCCCCCCHHHHHCCEEEECCCCCHHHHCCCEEEECCCCCCEEEEEEHHHHHHHHHHCC
NAIVIAKDQKTIGIGAGQMNRVGAAKIALKAAGRLCSDAVLASDGFFPFADTVEIANEYG
CEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
IKAIIQPGGSLRDQESIDMCNSKGISMVFTQKRHFLH
CEEEECCCCCCCCCHHHHHHCCCCCEEEEECCHHCCC
>Mature Secondary Structure 
SPLALVSVSDKKNIIPFCKELVEHFNYKILSSGGTAKHLIEAKIPVIKVADFTNSPEIL
CCEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCEEEEECCCCCCHHC
GGRVKTLHPKIHGGILAIRTDEEHKKDIEANNLELIDLVVVNLYPFKKTVDGGAKWEDAI
CCCEEEECCCCCCCEEEEECCHHHHHCCCCCCEEEEEEEEEEEECCHHCCCCCCHHHHHH
ENIDIGGPSMIRSAAKNHKDVSVLVDSSQYQSFLEESKKGELKDSYKAKLALEAFQHTAD
HCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
YDTAISNWIRKERDLQSSKYIESYPLIKTLRYGENPHQKAFWYGLSNIGWNSAEQLQGKD
HHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHCCCC
LSYNNLLDLESALSTVLEFGYTEKDELATDMVASVILKHNNPCGASMSNSASKAFLNALE
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
CDSVSAFGGIVAFNSNVDSETAIHLKDIFLECVVAPSFDEEALEILKVKKNLRILKISKD
CCCCHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECHH
QLPQKNQNSTKSIMGGLLVQDTDDSEEKTENWISVTNKNPSNQINLDLNFAWKICKHVKS
HCCCCCCCCHHHHHCCEEEECCCCCHHHHCCCEEEECCCCCCEEEEEEHHHHHHHHHHCC
NAIVIAKDQKTIGIGAGQMNRVGAAKIALKAAGRLCSDAVLASDGFFPFADTVEIANEYG
CEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
IKAIIQPGGSLRDQESIDMCNSKGISMVFTQKRHFLH
CEEEECCCCCCCCCHHHHHHCCCCCEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA