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The map label for this gene is glyA [H]

Identifier: 123967817

GI number: 123967817

Start: 257996

End: 259267

Strand: Reverse

Name: glyA [H]

Synonym: A9601_02801

Alternate gene names: 123967817

Gene position: 259267-257996 (Counterclockwise)

Preceding gene: 123967820

Following gene: 123967816

Centisome position: 15.53

GC content: 35.61

Gene sequence:

>1272_bases
ATGAATATCCTTCAAAATCTTAAAGAAAGTGATCCAGTAATATCAAATTTTATCAACTCTGAAAAAAATAGGCAGGAAAC
TCATCTTGAGTTAATCGCAAGCGAAAATTTCGCATCAATTGCTGTTATGCAGGCTCAAGGTTCAGTCCTTACAAATAAAT
ACGCCGAGGGGTTACCTCAAAAAAGATATTACGGGGGATGTGAATTTGTTGATGAAATCGAAGAATTAGCTATTCAGAGA
GCGAAAAAATTATTTAATGCAAATTGGGCTAATGTTCAACCCCATAGTGGAGCACAGGCAAATGCTGCTGTTTTCCTAAG
TCTACTTAAACCTGGCGACACAATCATGGGGATGGATTTATCTCATGGTGGACACTTAACACATGGGTCTCCAGTAAATA
TGAGTGGTAAGTGGTTCAATGCAGTTCACTATGGTGTAAATAAAGAAACTAGTGAATTAAATTTTGATGAAATAAGAGAG
ATAGCACTTGAAAAAAAACCAAAATTGATCATATGCGGATATTCTGCTTATCCAAGAACAATCGATTTTGAATCGTTTAG
AAATATTGCAGATGAAGTTGGGGCTTTTTTAATGGCTGATATTGCACATATTGCCGGTCTTGTAGCAAGTAAACTTCATC
CAAATCCAATACCTCATTGTGATGTAGTAACTACAACTACTCATAAAACATTAAGAGGGCCTAGAGGGGGACTTATCTTA
TGTAAAGATGCAGAATTTGGAAAGAAATTTGATAAATCTGTTTTTCCTGGCACTCAGGGCGGGCCCCTCGAACATATAAT
AGCCGCTAAAGCAGTCGCATTTAGAGAAGCCTTACAGCCAGATTTCGTTAATTATTCCCAACAAGTAATAAAAAATGCAA
AAGTTCTAGCTTCAACTTTAATAAATAGAGGTATCAATATCGTTAGTGGAGGCACTGATAATCATATTGTTTTACTCGAT
TTAAGGAGTATCAATATGACTGGTAAAATTGCTGACTTGCTTGTAAGTGAAGTTAATATCACTGCAAATAAAAATACTGT
TCCATTTGATCCTGAATCACCTTTTGTAACCAGCGGACTAAGGTTAGGAACTGCTGCTTTAACTACTAGAGGCTTTAATG
AGAATGCTTTTGCTGAAGTTGGCGAAATTATTGCTGATAGATTACTTAACCCAGACAATTCACTGATTGAAAGTCAATGT
AAAGAAAGAGTATTAACCTTATGTAATCGTTTTCCTCTTTATGAAGGCAAACTTGAAGCATCAATTAAATGA

Upstream 100 bases:

>100_bases
GAGTTCGAATCTCTCCAGGCGCGTTTAAAATTCTGAAATATTCTTTTTATATTTTTCTAAAAAATATCGTCTATATTATG
GGTATTACTTATCAAATTCA

Downstream 100 bases:

>100_bases
GTCCTAACTCCAAGGGAGTTGAGATTCTTTCAATTGGAACAGAGCTACTCTTAGGAAATATTATAAATACAAATGCTCAA
TGGATTTCTGAACAGTTGTC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNILQNLKESDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALEKKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPHCDVVTTTTHKTLRGPRGGLIL
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFREALQPDFVNYSQQVIKNAKVLASTLINRGINIVSGGTDNHIVLLD
LRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDNSLIESQC
KERVLTLCNRFPLYEGKLEASIK

Sequences:

>Translated_423_residues
MNILQNLKESDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALEKKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPHCDVVTTTTHKTLRGPRGGLIL
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFREALQPDFVNYSQQVIKNAKVLASTLINRGINIVSGGTDNHIVLLD
LRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDNSLIESQC
KERVLTLCNRFPLYEGKLEASIK
>Mature_423_residues
MNILQNLKESDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALEKKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPHCDVVTTTTHKTLRGPRGGLIL
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFREALQPDFVNYSQQVIKNAKVLASTLINRGINIVSGGTDNHIVLLD
LRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDNSLIESQC
KERVLTLCNRFPLYEGKLEASIK

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=47.8908188585608, Blast_Score=360, Evalue=1e-100,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=47.8908188585608, Blast_Score=360, Evalue=1e-100,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=47.8908188585608, Blast_Score=360, Evalue=1e-100,
Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=47.8908188585608, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI261862346, Length=403, Percent_Identity=47.6426799007444, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI22547186, Length=405, Percent_Identity=47.1604938271605, Blast_Score=334, Evalue=8e-92,
Organism=Homo sapiens, GI22547189, Length=391, Percent_Identity=45.7800511508951, Blast_Score=306, Evalue=2e-83,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=56.2043795620438, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI25144732, Length=404, Percent_Identity=45.7920792079208, Blast_Score=353, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=404, Percent_Identity=45.7920792079208, Blast_Score=353, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=43.640897755611, Blast_Score=346, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=405, Percent_Identity=42.2222222222222, Blast_Score=322, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=46.969696969697, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=46.969696969697, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46314; Mature: 46314

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILQNLKESDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQ
CCHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCC
KRYYGGCEFVDEIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALEKKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC
IDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPHCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCEEE
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFREALQPDFVNYSQQVIKNAKVLASTL
ECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
INRGINIVSGGTDNHIVLLDLRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNENAFAEVGEIIADRLLNPDNSLIESQCKERVLTLCNRFPLYEGKLEA
HHCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SIK
CCC
>Mature Secondary Structure
MNILQNLKESDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQ
CCHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCC
KRYYGGCEFVDEIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALEKKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC
IDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPHCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCCCCCEEE
CKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFREALQPDFVNYSQQVIKNAKVLASTL
ECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
INRGINIVSGGTDNHIVLLDLRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNENAFAEVGEIIADRLLNPDNSLIESQCKERVLTLCNRFPLYEGKLEA
HHCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA