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The map label for this gene is pth

Identifier: 123967809

GI number: 123967809

Start: 251247

End: 251849

Strand: Reverse

Name: pth

Synonym: A9601_02721

Alternate gene names: 123967809

Gene position: 251849-251247 (Counterclockwise)

Preceding gene: 123967810

Following gene: 123967808

Centisome position: 15.08

GC content: 27.2

Gene sequence:

>603_bases
ATGAATGAAATATATTTAATTGGACTAGGGAATCCTGGTAAAAAATATTTCAACAGTAGACATAATATAGGTTTCTTACT
ACTTGAAAGTTTTTCGAAAAAATATAATTCAAATTTTCTATTAAAAGATAAGCTTAAAAGTTCCTGCTCAGAATTTCAAA
TCAATAATTCTACTTTCAAGTTATTTTTACCAAATACATTTATGAATAACAGTGGAGATGCTGTCCGAGCAATAGTTGAT
TGGTACAAAATAAATTTAGATCAGATTTTGATAATAGTCGATGATAAAGATCTTCCCCTTGGGAAAATAAGATTTAGAAG
AAAAGGTAGCTCAGGTGGACATAACGGGCTTAAAAGCATCATTGAACAATTGCAAACACAAAATTTTAAGAGAATAAGAA
TTGGTATAGGTTCACCTCCTATTACAAATGGAAAAAATCATTTCAATACCATTTCTCATGTATTAGGAAATATTTCTTTA
GATGAAAAATCAATATTAGATAAAGTGTATAGCAGAGTAATAGAATCCCTGGAACAAATAAATACTAAAAAAGAAGAATA
TATAATTAATGAACTAAATTCTTTTGATAAAGACCAACCTTAA

Upstream 100 bases:

>100_bases
GAAGTTTGCTAAATAACTTTTAAAAATTTTTGTCTTTATTGATTAGTTATAGTTTATATATACTCATAATTTTCCATTAA
TAGAGATTTAGAAATAAATC

Downstream 100 bases:

>100_bases
GAAATGCATTCAAAACCTGAAACTATTGCCAGTGTAAATGTTAAGGAATATTGCTTCACAAAAAAGCAAATTCAGGGGGT
TGTGGAAGCTAGTCAATTTA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MNEIYLIGLGNPGKKYFNSRHNIGFLLLESFSKKYNSNFLLKDKLKSSCSEFQINNSTFKLFLPNTFMNNSGDAVRAIVD
WYKINLDQILIIVDDKDLPLGKIRFRRKGSSGGHNGLKSIIEQLQTQNFKRIRIGIGSPPITNGKNHFNTISHVLGNISL
DEKSILDKVYSRVIESLEQINTKKEEYIINELNSFDKDQP

Sequences:

>Translated_200_residues
MNEIYLIGLGNPGKKYFNSRHNIGFLLLESFSKKYNSNFLLKDKLKSSCSEFQINNSTFKLFLPNTFMNNSGDAVRAIVD
WYKINLDQILIIVDDKDLPLGKIRFRRKGSSGGHNGLKSIIEQLQTQNFKRIRIGIGSPPITNGKNHFNTISHVLGNISL
DEKSILDKVYSRVIESLEQINTKKEEYIINELNSFDKDQP
>Mature_200_residues
MNEIYLIGLGNPGKKYFNSRHNIGFLLLESFSKKYNSNFLLKDKLKSSCSEFQINNSTFKLFLPNTFMNNSGDAVRAIVD
WYKINLDQILIIVDDKDLPLGKIRFRRKGSSGGHNGLKSIIEQLQTQNFKRIRIGIGSPPITNGKNHFNTISHVLGNISL
DEKSILDKVYSRVIESLEQINTKKEEYIINELNSFDKDQP

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=174, Percent_Identity=26.4367816091954, Blast_Score=84, Evalue=6e-17,
Organism=Escherichia coli, GI1787455, Length=191, Percent_Identity=34.0314136125654, Blast_Score=101, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PROMS (A2BP49)

Other databases:

- EMBL:   CP000551
- RefSeq:   YP_001008667.1
- ProteinModelPortal:   A2BP49
- SMR:   A2BP49
- STRING:   A2BP49
- GeneID:   4716957
- GenomeReviews:   CP000551_GR
- KEGG:   pmb:A9601_02721
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   A2BP49
- ProtClustDB:   PRK05426
- BioCyc:   PMAR146891:A9601_02721-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22886; Mature: 22886

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIYLIGLGNPGKKYFNSRHNIGFLLLESFSKKYNSNFLLKDKLKSSCSEFQINNSTFK
CCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEHHHHHCCHHHEEECCCEEE
LFLPNTFMNNSGDAVRAIVDWYKINLDQILIIVDDKDLPLGKIRFRRKGSSGGHNGLKSI
EEECCHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHH
IEQLQTQNFKRIRIGIGSPPITNGKNHFNTISHVLGNISLDEKSILDKVYSRVIESLEQI
HHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
NTKKEEYIINELNSFDKDQP
CCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNEIYLIGLGNPGKKYFNSRHNIGFLLLESFSKKYNSNFLLKDKLKSSCSEFQINNSTFK
CCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCEEHHHHHCCHHHEEECCCEEE
LFLPNTFMNNSGDAVRAIVDWYKINLDQILIIVDDKDLPLGKIRFRRKGSSGGHNGLKSI
EEECCHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHH
IEQLQTQNFKRIRIGIGSPPITNGKNHFNTISHVLGNISLDEKSILDKVYSRVIESLEQI
HHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
NTKKEEYIINELNSFDKDQP
CCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA