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The map label for this gene is met3 [H]

Identifier: 123967785

GI number: 123967785

Start: 231696

End: 232871

Strand: Reverse

Name: met3 [H]

Synonym: A9601_02481

Alternate gene names: 123967785

Gene position: 232871-231696 (Counterclockwise)

Preceding gene: 123967786

Following gene: 123967784

Centisome position: 13.95

GC content: 33.59

Gene sequence:

>1176_bases
ATGGAATTACAACAAAAAACTAAAACAGATAATAATGGACTAATACCGCCTTATGGAGGGGAACTAAAAAATTTAATTAT
CAAAGATAAAAGCCTTAAAAATGAACTTATTTCTAAAGCTACTTATGAGTTTGAATGTAGCGAGAGAAATGCATGCGATG
TAGAACTTTTAATGGTTGGAGCTTTTTCTCCATTGGAAGGTTTTATGGATGCAAATAACTACAATTCGGTGATTAAGAAT
AATAGAAATACAAGCGGGTTGCTTTTTGGCTTGCCTATTGTATTTGATTCCAATAATGAAAAAGTAAAAACTGGAGAGAC
AATATTACTTACCTATAAAAAACAAAAAATAGCAGTTTTAGAAGTTAGCTCTAAATGGGAGCCTGACAAATCCTTAGAAG
CTGAACTTTGTTATGGTACTAATTCTTTAGATCATCCTGCTGTTAAGATGATTTTTAACGAGAGAGGTAGATTTTATATA
GGAGGAAGAGTTTATGGTTTCGAACTGCCAACTAGAGAATTCCCCTGCAAAACTCCAGAAGAAGTTAGATCTACACTGCC
ACCAAATCATGATGTAGTTGCATTTCAATGCAGAAATCCAATTCATAGAGCACATTATGAATTATTTACTAATGCCTTAC
TTTCAGAAAATGTCTCCTCTAAATCAGTTGTTTTAGTTCATCCAACTTGTGGACCAACTCAACAAGATGATATCCCGGGG
AAAGTTAGATATTTGACATATAAAGAATTAGAAGAGGAAATATCTGATGAAAGAATAAAATGGGCTTTTTTACCTTATTC
AATGCATATGGCGGGGCCAAGAGAAGCTTTGCAACATATGATAATCAGAAGAAATTATGGCTGCACCCACTTTATTATTG
GTAGAGATATGGCTGGTTGTAAGTCTTCATCAACTGGTGAGGATTTTTATGGTCCATATGACGCCCAGAATTTTGCAAAT
AAGTGCGCAGATGAATTGATGATGCAAACTGTTCCTTCAAAAAATTTAGTTTATACGAAGGAAAAAGGATATATAACAGC
TGAAGAAGCCAAAGAATTAAATTATGAAATTATGAAACTTAGTGGTACTGAATTTAGAAAGAAATTAAGGAATGGCGAAC
CAATTCCTGAATGGTTTGCATTCAAAAGTGTAGTAGATGTTCTAAGACGCTCTTAA

Upstream 100 bases:

>100_bases
TGGGGAGCTTTACGGAAGAAAAGCATAAATCCTACTCGAGAGAAAAAGGGGGTTAAACCCCTCTTTTTTTTTCAAAATTT
TTCTTTAATCAATTTTAAAA

Downstream 100 bases:

>100_bases
TAATGTTTTATTATTAGTATTATAGATTTATTAAAGATTTTTTATTGTGAACAAACGTTGGAGAAACGTAGGACTTTACG
TTCTAGCTGTTATTACTGTA

Product: ATP-sulfurylase

Products: NA

Alternate protein names: Sulfate adenylyltransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MELQQKTKTDNNGLIPPYGGELKNLIIKDKSLKNELISKATYEFECSERNACDVELLMVGAFSPLEGFMDANNYNSVIKN
NRNTSGLLFGLPIVFDSNNEKVKTGETILLTYKKQKIAVLEVSSKWEPDKSLEAELCYGTNSLDHPAVKMIFNERGRFYI
GGRVYGFELPTREFPCKTPEEVRSTLPPNHDVVAFQCRNPIHRAHYELFTNALLSENVSSKSVVLVHPTCGPTQQDDIPG
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCADELMMQTVPSKNLVYTKEKGYITAEEAKELNYEIMKLSGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS

Sequences:

>Translated_391_residues
MELQQKTKTDNNGLIPPYGGELKNLIIKDKSLKNELISKATYEFECSERNACDVELLMVGAFSPLEGFMDANNYNSVIKN
NRNTSGLLFGLPIVFDSNNEKVKTGETILLTYKKQKIAVLEVSSKWEPDKSLEAELCYGTNSLDHPAVKMIFNERGRFYI
GGRVYGFELPTREFPCKTPEEVRSTLPPNHDVVAFQCRNPIHRAHYELFTNALLSENVSSKSVVLVHPTCGPTQQDDIPG
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCADELMMQTVPSKNLVYTKEKGYITAEEAKELNYEIMKLSGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS
>Mature_391_residues
MELQQKTKTDNNGLIPPYGGELKNLIIKDKSLKNELISKATYEFECSERNACDVELLMVGAFSPLEGFMDANNYNSVIKN
NRNTSGLLFGLPIVFDSNNEKVKTGETILLTYKKQKIAVLEVSSKWEPDKSLEAELCYGTNSLDHPAVKMIFNERGRFYI
GGRVYGFELPTREFPCKTPEEVRSTLPPNHDVVAFQCRNPIHRAHYELFTNALLSENVSSKSVVLVHPTCGPTQQDDIPG
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCADELMMQTVPSKNLVYTKEKGYITAEEAKELNYEIMKLSGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS

Specific function: Unknown

COG id: COG2046

COG function: function code P; ATP sulfurylase (sulfate adenylyltransferase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI46094058, Length=356, Percent_Identity=30.0561797752809, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI62912492, Length=363, Percent_Identity=28.099173553719, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI34447231, Length=358, Percent_Identity=28.4916201117318, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17542422, Length=429, Percent_Identity=27.039627039627, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322469, Length=389, Percent_Identity=38.3033419023136, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24667032, Length=376, Percent_Identity=28.4574468085106, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24667028, Length=376, Percent_Identity=28.4574468085106, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24667036, Length=376, Percent_Identity=28.4574468085106, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI116007838, Length=376, Percent_Identity=28.4574468085106, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24667044, Length=376, Percent_Identity=28.4574468085106, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24667040, Length=376, Percent_Identity=28.4574468085106, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891
- InterPro:   IPR015947
- InterPro:   IPR014729
- InterPro:   IPR020792
- InterPro:   IPR002650 [H]

Pfam domain/function: PF01583 APS_kinase; PF01747 ATP-sulfurylase [H]

EC number: =2.7.7.4; =2.7.1.25 [H]

Molecular weight: Translated: 44569; Mature: 44569

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQQKTKTDNNGLIPPYGGELKNLIIKDKSLKNELISKATYEFECSERNACDVELLMVG
CCCCCCCCCCCCCCCCCCCCHHHHHEECCHHHHHHHHHHCEEEEECCCCCCCCEEEEEEE
AFSPLEGFMDANNYNSVIKNNRNTSGLLFGLPIVFDSNNEKVKTGETILLTYKKQKIAVL
CCCHHHHHHCCCCCHHHHHCCCCCCEEEEEEEEEECCCCCEEECCCEEEEEEECCEEEEE
EVSSKWEPDKSLEAELCYGTNSLDHPAVKMIFNERGRFYIGGRVYGFELPTREFPCKTPE
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCEEECCEEEEEECCCCCCCCCCHH
EVRSTLPPNHDVVAFQCRNPIHRAHYELFTNALLSENVSSKSVVLVHPTCGPTQQDDIPG
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGC
EEEEEEHHHHHHHHCCCCEEEEEECEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
KSSSTGEDFYGPYDAQNFANKCADELMMQTVPSKNLVYTKEKGYITAEEAKELNYEIMKL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHCCEEEEEE
SGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELQQKTKTDNNGLIPPYGGELKNLIIKDKSLKNELISKATYEFECSERNACDVELLMVG
CCCCCCCCCCCCCCCCCCCCHHHHHEECCHHHHHHHHHHCEEEEECCCCCCCCEEEEEEE
AFSPLEGFMDANNYNSVIKNNRNTSGLLFGLPIVFDSNNEKVKTGETILLTYKKQKIAVL
CCCHHHHHHCCCCCHHHHHCCCCCCEEEEEEEEEECCCCCEEECCCEEEEEEECCEEEEE
EVSSKWEPDKSLEAELCYGTNSLDHPAVKMIFNERGRFYIGGRVYGFELPTREFPCKTPE
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCEEECCEEEEEECCCCCCCCCCHH
EVRSTLPPNHDVVAFQCRNPIHRAHYELFTNALLSENVSSKSVVLVHPTCGPTQQDDIPG
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGC
EEEEEEHHHHHHHHCCCCEEEEEECEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
KSSSTGEDFYGPYDAQNFANKCADELMMQTVPSKNLVYTKEKGYITAEEAKELNYEIMKL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHCCEEEEEE
SGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]